Clonorchis sinensis infection contributes to hepatocellular carcinoma progression via enhancing angiogenesis.

Background: Clonorchis sinensis (C. sinensis) infection plays an important role in the progression of hepatocarcinogenesis. However, its specific role in HCC progression remains unclear.

Development and Validation of a Nomogram for Predicting Survival Based on Ferritin and Transferrin Ratio in Breast Cancer Patients.

Background: Our objective is to develop a predictive model utilizing the ferritin and transferrin ratio (FTR) and clinical factors to forecast overall survival (OS) in breast cancer (BC) patients.

Methods: We conducted a retrospective analysis of clinical data from 2858 BC patients diagnosed between 2013 and 2021. Subsequently, the cohort of 2858 BC patients underwent random assignment into distinct subsets: a training cohort comprising 2002 patients and a validation cohort comprising 856 patients, maintaining a proportional ratio of 7:3.

Enteral nutrition in children and adolescents who receive extracorporeal membrane oxygenation and its impact on complications and mortality: A systematic review and meta-analysis.

Enteral nutrition (EN) is one method of nutrition support for children and adolescents receiving extracorporeal membrane oxygenation (ECMO) therapy, and there are no guidelines for its use in this population. We conducted a systematic review to determine whether EN is effective and safe in children supported by ECMO. We searched the Cochrane Library database, MEDLINE, and Embase on Ovid in March 2023 to identify studies that evaluated children and adolescents who received ECMO and were treated with EN.

Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis.

Background: Extensive evidence links Clonorchis sinensis (C. sinensis) to cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less acknowledged, and the underlying mechanism remains unclear. This study was designed to investigate the association between C.

A Study on the Performance of Prestressed Concrete Containment with Carbon Fiber-Reinforced Polymer Tendons under Internal Pressure.

As the last barrier to preventing nuclear leakage, it is crucial to enhance the load-bearing capacity and cracking resistance of nuclear containment under internal pressure accidents. Currently, fiber-reinforced polymers are widely used in prestressing concrete structures because of their superior performance, but little research has been conducted on fiber-reinforced polymers in the field of nuclear power plants. In this paper, carbon fiber-reinforced polymer (CFRP) is used as a prestressing tendon material instead of traditional steel strands to study the damage mode of the new type of containment under internal pressure and the feasibility of using CFRP as prestressing tendons.

The association of serum IL-33/ST2 expression with hepatocellular carcinoma.

Background: IL-33 is a multifunctional cytokine with dual functions. However, the clinicopathological and prognostic significance of IL-33 in cancer patients, especially in patients with hepatocellular carcinoma (HCC), remains controversial. Therefore, we conducted a study of 565 patients with HCC and 561 healthy controls and performed a meta-analysis to quantitatively evaluate the above problems.

Failure Mechanism of Fiber-Reinforced Prestressed Concrete Containments under Internal Pressure Considering Different Fiber Types.

Current investigations of performance improvement in prestressed concrete containment vessels (PCCVs) with fiber reinforcement are scarce, and the type of fiber to select for PCCVs is not explicitly stated. The failure mechanism of PCCVs with fiber reinforcement under internal pressure is investigated in this paper. The effects of different fiber types, including rigid fiber, flexible fiber, and hybrid fiber, are considered for the creation of fiber-reinforced PCCVs.

Colorectal Cancer Cell Differentiation Trajectory Predicts Patient Immunotherapy Response and Prognosis.

Objectives: This study aimed to investigate the differentiation state and clinical significance of colorectal cancer cells, as well as to predict the immune response and prognosis of patients based on differentiation-related genes of colorectal cancer.

Introduction: Colorectal cancer cells exhibit different differentiation states under the influence of the tumor microenvironment, which determines the cell fates.

Methods: We combined single-cell sequencing (scRNA-seq) data from The Cancer Genome Atlas source with extensive transcriptome data from the Gene Expression Omnibus database.

Time-Dependent Seismic Performance of Coastal Bridges Reinforced with Hybrid FRP and Steel Bars.

To increase the durability and seismic resilience of coastal bridges, a hybrid reinforced concrete (HRC) bridge that incorporates both glass fiber-reinforced polymer (GFRP) bars and steel bars is proposed. The time-dependent seismic performance of the HRC bridge is comprehensively investigated at three levels, namely the material, bridge column and bridge structure levels. First, the decrease of tensile strength of GFRP bars over time is analyzed based on the Arrhenius theory, and corrosion initiation time and performance deterioration of steel bars are determined by Fick's second law and an empirical formula.

The role of Smad1/5 in mantle immunity of the pearl oyster Pinctada fucata martensii.

The Smad protein family is an important medium for transducing BMP-Smads signals, and which have been proved that their important role in regulating shell biomineralization in Pinctada fucata martensii in our previous study. The members of TGF-β superfamily were involved in innate immunity in vertebrates and invertebrates, and Smad regulatory networks construct a balanced immune system. However, little is known about the role of Smad1/5 in immunity in P.

, , and Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population.

The interleukin- (IL-) 33/ axis plays a pivotal role in tumorigenesis through influencing cancer stemness and other mechanisms. is one of the critical markers of hepatocellular carcinoma (HCC) among the cancer stem cells (CSCs). There is still a lack of gene single-nucleotide polymorphisms (SNPs) combined with / pathway single-nucleotide polymorphisms in HCC susceptibility analysis literature, although and / have been reported separately in human cancers.

SNP rs2240688 in gene on susceptibility and clinicopathological features of hepatocellular carcinoma.

Background: CD133 is one of the important cancer stem cells (CSCs) markers of hepatocellular carcinoma (HCC). The aim of this study was to explore the relationship between CD133 single-nucleotide polymorphisms (SNPs) and risk factors associated with HCC susceptibility and clinicopathological features in HCC cases and healthy controls from the Guangxi region of southern China.

Methods: A case control study was conducted, including 565 HCC patients and 561 control subjects.

PacBio single molecule long-read sequencing provides insight into the complexity and diversity of the Pinctada fucata martensii transcriptome.

Background: The pearl oyster Pinctada fucata martensii is an economically valuable shellfish for seawater pearl production, and production of pearls depends on its growth. To date, the molecular mechanisms of the growth of this species remain poorly understood. The transcriptome sequencing has been considered to understanding of the complexity of mechanisms of the growth of P.

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies.

Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) gene polymorphisms and risk of cancer.

Assessing the metabolic effects of aromatherapy in human volunteers.

Aromatherapy, a form of complementary and alternative medicine (CAM) that uses essential oils through inhalation, is believed to enhance physical and spiritual conditions. Although clinical studies suggest that the use of essential oils may have therapeutic potential, evidence for the efficacy of aromatherapy in treating medical conditions remains poor, with a particular lack of studies employing rigorous analytical methods that capture its identifiable impact on human biology. Here, we report a comprehensive metabolomics study that reveals metabolic changes in people after exposed to aroma inhalation for 10 continuous days.

The metabolic responses to aerial diffusion of essential oils.

Anxiety disorders are the most prevalent psychiatric disorders and affect a great number of people worldwide. Essential oils, take effects through inhalation or topical application, are believed to enhance physical, emotional, and spiritual well-being. Although clinical studies suggest that the use of essential oils may have therapeutic potential, evidence for the efficacy of essential oils in treating medical conditions remains poor, with a particular lack of studies employing rigorous analytical methods that capture its identifiable impact on human biology.

[One-stage complete correction of 52 cases infantile aortic coarctation or interrupted aortic arch associated with intracardiac anomalies].

Objective: To sum up one-stage complete correction of infantile aortic coarctation (CoA) or interrupted aortic arch (IAA) associated with intracardiac anomalies through median sternotomy.

Methods: The clinical data of 52 infants with CoA or IAA associated with intracardiac anomalies from May 2004 to March 2010 was analyzed. There were 32 male and 20 female, aged from 25 d to 7 months with a mean of (2.