Newton-Simpson-based predictor-corrector methods for milling chatter stability prediction.

Milling chatter, a form of self-excited vibration, can cause significant damage in machining and manufacturing processes. By selecting appropriate milling parameters, milling chatter can be effectively mitigated without sacrificing milling efficiency. Within the framework of the semi-discretization scheme, this paper introduces the Newton-Simpson-based predictor-corrector methods to compute milling stability lobe diagrams.

Uncovering Druggable Targets in Aortic Dissection: An Association Study Integrating Mendelian Randomization, pQTL, and Protein-Protein Interaction Network.

Aortic dissection (AD) is a life-threatening acute aortic syndrome. There are limitations and challenges in the discovery and application of biomarkers and drug targets for AD. Mendelian randomization (MR) analysis is a reliable analytical method to identify effective therapeutic targets.

Insight into the quantum anomalous Hall states in two-dimensional kagome CrSe and FeS monolayers.

To realize the quantum anomalous Hall (QAH) effect in two-dimensional (2D) intrinsic magnetic materials, which combines insulating bulk states and metallic edge channel states, is still challenging in experiment. Here, based on first-principles calculations, we predicted two stable kagome-latticed QAH insulators: CrSe and FeS monolayers, with the Chern number = 1. It is found that both structures exhibit a large magnetic anisotropy energy and sizable band gaps, and a topological phase transition from = -1 to = 1 occurs when the magnetization orientation changes from the -axis to the --axis.

[Effect of deep needling "Tianshu" (ST25) on colonic motility in rats with slow transit constipation].

Objective: To observe the effect of acupuncture of "Tianshu"(ST25) at different depths on colonic transportation function, expressions of colonic substance P (SP) and interstitial cells of Cajal (ICC) in rats with slow transit constipation (STC), so as to explore its mechanisms underlying improvement of STC．.

Methods: Fifty male Wistar rats were selected and randomly divided into control，STC model，conventional acupuncture，deep needling group 1 and deep needling group 2 groups，with 10 rats in each group．The STC model was established by gavage of 1 mg/mL compound diphenoxylate suspension (10 mg/kg), once every other day for 21 days, and rats of the control group were given the same dose of distilled water by gavage．EA (2 Hz, 2 mA) was applied to "Tianshu"(ST25), with the acupuncture needle inserted to a depth of 3 mm for rats of the conventional acupuncture group, 4.5 mm for those of deep needling group 1, and 10 mm for those of the deep needling group 2.

New-Onset Sleep Disorders before Cardiac Surgery May Indicate an Increased Risk of Postoperative Atrial Fibrillation.

Purpose: We aimed to determine if sleep disorders before cardiac surgery indicate an increased risk of postoperative atrial fibrillation (POAF).

Methods: In this study, 238 patients undergoing coronary artery bypass grafting in our center were included. Patients were separated into the preoperative sleep disorder group and the control group.

Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation.

Unlabelled: This study sought to investigate the anti-amyloid β (Aβ) and anti-neuroinflammatory effects of catalpol in an Alzheimer's disease (AD) mouse model.

Methods: The effects of catalpol on Aβ formation were investigated by thioflavin T assay. The effect of catalpol on generating inflammatory cytokines from microglial cells and the cytotoxicity of microglial cells on HT22 hippocampal cells were assessed by real-time quantitative PCR, ELISA, redox reactions, and cell viability.

Revascularization-first strategy versus central repair-first strategy for acute type A aortic dissection complicated with mesenteric malperfusion syndrome: A meta-analysis.

Objective: The optimal therapeutic strategy for acute type A aortic dissection (ATAAD) accompanied by mesenteric malperfusion syndrome (mMPS) has not been fully elucidated. The intent of this meta-analysis was to analyze the effectiveness and safety of the revascularization-first strategy among patients with ATAAD complicated with mMPS through comprehensive comparisons with the central repair-first strategy.

Methods: Studies relevant to the comparison of the outcomes of early reperfusion combined with delayed proximal aortic repair and initial central repair in the treatment of ATAAD complicated with mMPS, were systematacially searched using PubMed, Cochrane Library, Web of Science and Embase up to June 30, 2022.

[Effect of electroacupuncture of "Tianshu"(ST25) at different frequencies on electromyography and immunoactivity of SP and VIP of colon in rats with slow transit constipation].

Objective: To observe the effect of electroacupuncture (EA) of bilateral "Tianshu"(ST25) at different frequencies on the first black stool discharge time, colonic electromyography (EMG) and immunoactivity of vasoactive intestinal peptide (VIP) and substance P (SP) in the colon tissue in rats with slow transit constipation (STC), so as to choose a better stimulating frequency in the treatment of STC.

Methods: A total of 50 male Wistar rats were randomized into control, model, 2 Hz-EA, 100 Hz- EA, and 2 Hz/100 Hz-EA groups, with 10 rats in each group. The STC model was established by intraperitoneal injection of compound diphenoxylate suspension fluid (10 mg/kg).

Ab Initio Study of Structural, Electronic and Magnetic Properties of TM&(B@C) (TM = V, Cr) Sandwich Clusters and Infinite Molecular Wires.

The geometrical structure, electronic and magnetic properties of B-endoped C (B@C) ligand sandwich clusters, TM&(B@C) (TM = V, Cr), and their one-dimensional (1D) infinite molecular wires, [TM&(B@C)], have been systematically studied using first-principles calculations. The calculations showed that the TM atoms can bond strongly to the pentagonal (η-coordinated) or hexagonal rings (η-coordinated) of the endoped C ligands, with binding energies ranging from 1.90 to 3.

Upgrading the school entry vaccination record check strategy to improve varicella vaccination coverage: results from a quasi-experiment study.

Background: The school entry vaccination record check strategy (SECS) is an appropriate opportunity to recommend vaccines for students to improve vaccination coverage (VC). However, it is only utilized for providing necessary catch-up vaccination for students who are missing the Expanded Program on Immunization (EPI) vaccines in China. We aimed to address that gap and quantify the relationship between the SECS policy and the increase of coverage in varicella vaccine (VarV).

Safety of Thread Embedding Acupuncture Therapy: A Systematic Review.

Objective: To evaluate the safety of thread embedding acupuncture therapy (TEAT) and discuss the prevention and treatment of some adverse events (AEs).

Methods: Review of databases, including China National Knowledge Infrastructure (CNKI), CBMdisc, Wanfang, VIP databases and English literature published in PubMed, MEDLINE, EMBASE and Web of Science, were searched from their inception to January 2020, randomized controlled trials (RCTs) and case reports in which AEs with TEAT were included. Cochrane Collaboration's tool and RevMan V.

Combustion Characteristics, Kinetics, and Thermodynamics of Pine Wood Through Thermogravimetric Analysis.

The thermal conversion of woody biomass is increasingly critical for the development of the energy processing technologies and fire safety engineering. The combustion characteristics, kinetics, and thermodynamics of pine wood were characterized through a thermogravimetric analyzer in the air atmosphere. There were two apparent peaks in the derivative TG curves for pine wood.

In vivo investigation on bio-markers of perimenopausal panic disorder and catgut embedding acupoints mechanism.

Background: Panic disorder (PD), defined by repeated and unexpected panic attacks, severely affects patients' living quality and social function. Perimenopausal women are high-risk group of PD and suffer greatly from it. Modern medicine therapies for this disorder have many side reactions and poor effects, so nonpharmacological modality is an urgent need.

Kinetics, Thermodynamics, and Volatile Products of Camphorwood Pyrolysis in Inert Atmosphere.

The kinetics, thermodynamics, and volatile products of camphorwood pyrolysis were investigated via thermogravimetry coupled with Fourier transform infrared (FTIR) spectroscopy at multiple heating rates. The kinetic triplets and thermodynamic parameters were estimated via model free combined with the model-fitting approach. The results showed that the pyrolysis of camphorwood in the conversion rate range from 0 to 0.

The impact of long-term moderate level of vaccination coverage for epidemiology of varicella in Lu'an, China: should we change immunisation strategy now?

As China implements the voluntary vaccination programme of one-dose of varicella vaccine (VarV) for decades, robust estimates of the impact of voluntary vaccination era on epidemiology of varicella are needed. We estimated the vaccination coverage (VC) of VarV by using surveillance data on immunisation. The descriptive epidemiological method was used to describe the changing epidemiology of varicella from 2007 to 2018.

Clinical characteristics and risk factors associated with breakthrough varicella during varicella outbreaks.

Background: Although a varicella vaccine has been available in China since 1998 in the private sector, varicella outbreaks and breakthrough varicella (BV) still occur. In 2018, four varicella outbreaks with high BV rate sequentially occurred in four schools in Lu'an, sparking local public health authority's concerns on the varicella vaccine. Therefore, we conducted this investigation to evaluate varicella vaccine effectiveness (VE), characterize BV, and detect potential risk factors associated with BV.

IGFBP2 Plays an Essential Role in Cognitive Development during Early Life.

Identifying the mechanisms underlying cognitive development in early life is a critical objective. The expression of insulin-like growth factor binding protein 2 (IGFBP2) in the hippocampus increases during neonatal development and is associated with learning and memory, but a causal connection has not been established. Here, it is reported that neurons and astrocytes expressing IGFBP2 are distributed throughout the hippocampus.

[Advance in the Treatment of Ph Chromosome Positive Acute Lymphoblastic Leukemia ---Review].

Abstract　　The curative efficacy of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) has been improved substantially with the introduction of tyrosine kinase inhibitors (TKIs). However, there is no consensus so far on the following issues, which TKIs should be chosen in combination with chemotherapeutic regimens; which regimen of intensive chemotherapy incorporated into TKIs would be more beneficial to patients. The prognosis of the patients with Ph ALL has been so significantly improved by the combinatorial treatment of TKIs and chemotherapy, thus it is necessary to reevaluate the role of allogeneic hematopoietic stem cell transplantation in the management of Ph ALL.

Comparative Pyrolysis Characteristics and Kinetics of Typical Hardwood in Inert and Oxygenous Atmosphere.

Combustion (pyrolysis with oxygen) and pyrolysis without oxygen are two potential methods to convert wood into biofuels or biochemicals. To evaluate which is preponderant to convert wood into biofuels or biochemicals and provide guidance for optimization of product yield, the pyrolysis characteristics and kinetics of typical hardwood (black walnut) are comparatively investigated in nitrogen and air employing thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC). Two model-free methods including Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) method are applied to obtain the kinetic parameters, and a model-fitting method called Coats-Redfern (CR) method is employed to estimate the reaction mechanism.

Pyrolysis Characteristics and Reaction Mechanisms of Pine Needles.

Pyrolysis has been considered as a promising method to utilize biomass by thermal cracking for energy or feedstock. In order to provide guidance for thermochemical process management of pine needle utilization by pyrolysis, the pyrolysis kinetics and reaction mechanism of one typical pine needle are investigated employing thermogravimetric analysis in nitrogen in the present study. Multi kinetics methods including model-free method and model-fitting method are adopted.

Functional Diversity of p53 in Human and Wild Animals.

The common understanding of p53 function is a genome guardian, which is activated by diverse stresses stimuli and mediates DNA repair, apoptosis, and cell cycle arrest. Increasing evidence has demonstrated p53 new cellular functions involved in abundant endocrine and metabolic response for maintaining homeostasis. However, is frequently mutant in human cancers, and the mutant p53 (Mut-p53) turns to an "evil" cancer-assistant.

Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination.

In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.

[Present situation and development direction of microacupuncture therapy].

There have been many reports of clinical and experimental researches of microacupuncture therapy, the relevant systematic works, teaching materials and national standards in recent decades. It shows that microacupuncture system has been formed and its influence has been promoted. While the rapid development of microacupuncture therapy, there are the problems and contradictions on nomenclature, explanation of theoretical basis, optimal indications, and multiple systems and schools, etc.