Raddeanin A suppresses intracellular Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.

Ethnopharmacological Relevance: The Anemonoides Raddeana (Rege) Holubhe is commonly employed in clinical practice as a traditional Chinese medicine for the treatment of conditions such as rheumatism and limb numbness. Raddeanin A (RA), an active compound derived from this Traditional Chinese Medicine (TCM), demonstrates specific anticancer properties against many tumorigeneses. However, the molecular mechanism underlying its effects on hepatocellular carcinoma (HCC) remains unexplored.

Morphological complexity promotes origination and extinction rates in ammonoids.

The causes of heterogeneity in evolutionary rates are a key question in macroevolution. Origination and extinction rates are closely related to abiotic factors, such as climate and geography, as well as biotic factors such as taxonomic richness and morphology, which are influenced by phylogeny. Studies on the relationship between morphology and macroevolution have focused on morphological traits, including body size, shape, color, and complexity, and have proposed biological laws, such as the zero-force evolutionary law and Cope's rule.

Visualization of the Distance-Dependent Synergistic Interaction in Heterogeneous Dual-Site Catalysis.

Understanding the characteristics of interfacial hydroxyl (OH) at the solid/liquid electrochemical interface is crucial for deciphering synergistic catalysis. However, it remains challenging to elucidate the influences of spatial distance between interfacial OH and neighboring reactants on reaction kinetics at the atomic level. Herein, we visualize the distance-dependent synergistic interaction in heterogeneous dual-site catalysis by using ex-situ infrared nanospectroscopy and in situ infrared spectroscopy techniques.

The dual-functional role of carboxylate in a nickel-iron catalyst towards efficient oxygen evolution.

The efficiency of the oxygen evolution reaction (OER) is severely limited by the sluggish proton-coupled electron transfer processes and inadequate long-term stability. Herein, we introduce a carboxylate group (TPA) to modify NiFe layered double hydroxide (NiFe LDH@TPA), resulting in notable improvements in both activity and stability. A combination of spectroscopic and theoretical investigations reveals the dual-functional role of incorporated TPA.

Regulating interaction with surface ligands on Au nanoclusters by multivariate metal-organic framework hosts for boosting catalysis.

While atomically precise metal nanoclusters (NCs) with unique structures and reactivity are very promising in catalysis, the spatial resistance caused by the surface ligands and structural instability poses significant challenges. In this work, Au(Cys) NCs are encapsulated in multivariate metal-organic frameworks (MOFs) to afford Au@M-MOF-74 (M = Zn, Ni, Co, Mg). By the MOF confinement, the Au NCs showcase highly enhanced activity and stability in the intramolecular cascade reaction of 2-nitrobenzonitrile.

Multivariate approach to assess the bioactive compounds of Atractylodes chinensis (DC.) Koidz in different harvest periods.

Background: The Atractylodes chinensis (DC.) Koidz (A. chinensis) Chinese herb possesses numerous therapeutic properties and is extensively utilized in the pharmaceutical industry.

Identification of K-determined reaction pathway for facilitated kinetics of CO electroreduction.

Cations such as K play a key part in the CO electroreduction reaction, but their role in the reaction mechanism is still in debate. Here, we use a highly symmetric Ni-N structure to selectively probe the mechanistic influence of K and identify its interaction with chemisorbed CO. Our electrochemical kinetics study finds a shift in the rate-determining step in the presence of K.

DSCR1-1 attenuates osteoarthritis-associated chondrocyte injury by regulating the CREB1/ALDH2/Wnt/β-catenin axis: An in vitro and in vivo study.

The progression of osteoarthritis (OA) includes the initial inflammation, subsequent degradation of the extracellular matrix (ECM), and chondrocyte apoptosis. Down syndrome candidate region 1 (DSCR1) is a stress-responsive gene and expresses in varied types of cells, including chondrocytes. Bioinformatics analysis of GSE103416 and GSE104739 datasets showed higher DSCR1 expression in the inflamed cartilage tissues and chondrocytes of OA.

Edge-Rich Pt-O-Ce Sites in CeO Supported Patchy Atomic-Layer Pt Enable a Non-CO Pathway for Efficient Methanol Oxidation.

Rational design of efficient methanol oxidation reaction (MOR) catalyst that undergo non-CO pathway is essential to resolve the long-standing poisoning issue. However, it remains a huge challenge due to the rather difficulty in maximizing the non-CO pathway by the selective coupling between the key *CHO and *OH intermediates. Here, we report a high-performance electrocatalyst of patchy atomic-layer Pt epitaxial growth on CeO nanocube (Pt ALs/CeO) with maximum electronic metal-support interaction for enhancing the coupling selectively.

Restoring colistin sensitivity in colistin-resistant and : combinatorial use of berberine and EDTA with colistin.

Unlabelled: The appearance and prevalence of multidrug-resistance (MDR) Gram-negative bacteria (GNB) have limited our antibiotic capacity to control bacterial infections. The clinical efficacy of colistin (COL), considered as the "last resort" for treating GNB infections, has been severely hindered by its increased use as well as the emergence and prevalence of mobile colistin resistance (MCR)-mediated acquired drug resistance. Identifying promising compounds to restore antibiotic activity is becoming an effective strategy to alleviate the crisis of increasing MDR.

Highly efficient anion exchange membrane water electrolyzers via chromium-doped amorphous electrocatalysts.

In-depth comprehension and modulation of the electronic structure of the active metal sites is crucial to enhance their intrinsic activity of electrocatalytic oxygen evolution reaction (OER) toward anion exchange membrane water electrolyzers (AEMWEs). Here, we elaborate a series of amorphous metal oxide catalysts (FeCrO, CoCrO and NiCrO) with high performance AEMWEs by high-valent chromium dopant. We discover that the positive effect of the transition from low to high valence of the Co site on the adsorption energy of the intermediate and the lower oxidation barrier is the key factor for its increased activity by synchrotron radiation in-situ techniques.

Symmetry Evolution Induced 2D Pt Single Atom Catalyst with High Density for Alkaline Hydrogen Oxidation.

The performance of single-atom catalysts is greatly influenced by the chemical environment surrounding the central atom. Here, a salt-assisted method is employed to transform the tetrahedral coordination structure of zeolitic imidazolate frameworks - 8 (ZIF-8) into a planar square coordination structure without altering the ligands. During the subsequent carbonization process, concurrent with the evaporation of zinc atoms, the structure of the nitrogen and carbon carriers (NC carriers) undergoes a transition from five-membered rings to six-membered rings to preserve the 2D structure.

Development and validation of a federated learning framework for detection of subphenotypes of multisystem inflammatory syndrome in children.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection. The highly diverse clinical features of MIS-C necessities characterizing its features by subphenotypes for improved recognition and treatment. However, jointly identifying subphenotypes in multi-site settings can be challenging.

Alleviating OH Blockage on the Catalyst Surface by the Puncture Effect of Single-Atom Sites to Boost Alkaline Water Electrolysis.

Nonprecious transition metal catalysts have emerged as the preferred choice for industrial alkaline water electrolysis due to their cost-effectiveness. However, their overstrong binding energy to adsorbed OH often results in the blockage of active sites, particularly in the cathodic hydrogen evolution reaction. Herein, we found that single-atom sites exhibit a puncture effect to effectively alleviate OH blockades, thereby significantly enhancing the alkaline hydrogen evolution reaction (HER) performance.

Landslide susceptibility zonation using the analytical hierarchy process (AHP) in the Great Xi'an Region, China.

This study aims to delineate landslide susceptibility maps using the Analytical Hierarchy Process (AHP) method for the Great Xi'an Region, China, which is a key planning project for urban construction in Shaanxi Province, China from 2021 to 2035. Multiple data as elevation, slope, aspect, curvature, river density, soil, lithology, and land use have been considered for delineating the landslide susceptibility maps. Spatially thematic layers and distributed maps of all the aforementioned parameters were created in a GIS environment.

Highly dispersed ultrafine PtCo alloy nanoparticles on unique composite carbon supports for proton exchange membrane fuel cells.

The design of highly efficient and robust platinum-based electrocatalysts is pivotal for proton exchange membrane fuel cells (PEMFC). One of the long-standing issues for PEMFC is the rapid deactivation of the catalyst under working conditions. Here, we report a simple synthesis strategy for ultrafine PtCo alloy nanoparticles loaded on a unique carbon support derived from a zeolitic imidazolate framework-67 (ZIF-67) and Ketjen Black (KB) composite, exhibiting a remarkable catalytic performance toward the oxygen reduction reaction (ORR) and PEMFC.