Association of RAN and RANBP2 Gene Polymorphisms With Glioma Susceptibility in Chinese Children.

Background: Glioma is the most prevalent pediatric central nervous system malignancy. RAN, member RAS oncogene family (RAN), is a key signaling molecule that regulates the polymerization of microtubules during mitosis. RAN binding protein 2 (RANBP2) is involved in DNA replication, mitosis, metabolism, and tumorigenesis.

is a Potential Biomarker and Therapeutic Target for Glioblastoma.

Glioblastoma (GBM) is a type of central nervous system malignancy. In our study, we determined the effect of in GBM patients through The Cancer Genome Atlas (TCGA) data analysis, and studied the effects of on GBM cell function to estimate its potential as a therapeutic target. Gene expression profiles of glioblastoma cohort were acquired from TCGA database and analyzed to look for central genes that may serve as GBM therapeutic targets.

CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children.

Objective: Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 (CASC15) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide polymorphisms (SNPs) on glioma risk.

Genetic variants in gene and glioma susceptibility in Chinese children: A multicenter case-control study.

Background: Glioma is one of the central nervous system (CNS) tumors in children, accounting for 80% of malignant brain tumors. Nucleotide excision repair (NER) is a vital pathway during DNA damage repair progression. Xeroderma pigmentosum group D (XPD) or excision repair cross-complementing group 2 (ERCC2) is a critical factor in the NER pathway, playing an indispensable role in the DNA repair process.

AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children.

Introduction: Central nervous system (CNS) tumors comprise 15-20% of all malignancies occurring in childhood and adolescence. Previous researches have shown that overexpression and amplification of the AURKA gene could induce multiple human malignancies, with which the connection of CNS tumor susceptibility has not been extensively studied.

Material And Methods: In this study, we assessed whether and to what extent AURKA gene single nucleotide polymorphisms (SNPs) (rs1047972 C > T, rs2273535 T > A, rs8173 G > C) were associated with CNS tumor susceptibility, based on a case-control analysis in 191 CNS tumor patients and 248 controls.

Associations between gene polymorphisms and central nervous system tumor susceptibility.

Importance: LIM domain only 1 () gene polymorphisms were previously found to be implicated in the risk of several cancers. No available studies were performed regarding the predisposing effect of gene single nucleotide polymorphisms (SNPs) on central nervous system (CNS) tumor risk.

Objective: We aimed to determine whether the gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in China.

Association Between Gene Polymorphisms and Glioma Susceptibility in Chinese Children.

Gliomas are the most prevalent brain tumors among children and adolescents. The occurrence and development of various malignant tumors is closely related with gene, but its relationship with glioma susceptibility has not been widely discovered. In this case-control study, we conducted four single nucleotide polymorphisms (SNPs) (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) of gene to investigate whether they increase the risk of glioma.

Investigation of the Relationship between Gene Polymorphisms and Glioma Susceptibility in Chinese Children.

Glioma is a common central nervous system tumors in children. has a range of functions that are disrupted in various tumor cells, and may contribute to the occurrence and development of glioma. Two single nucleotide polymorphisms (rs4645943C>T and rs2070583 A>G) were genotyped in 190 cases and 248 controls from Wenzhou and Guangzhou hospitals.

Association of Polymorphisms with Glioma Susceptibility in Chinese Children.

Background: Glioma is a malignant central nervous system tumor in children, with poor outcomes and prognosis. is a proto-oncogene with increased expression in various malignancies.

Methods: We explored the association of polymorphisms with glioma susceptibility in Chinese children using a case-control study (191 cases, 248 controls).

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.

Hypoxic-ischemic encephalopathy (HIE) is recognized as the main cause of neonatal death, and efficient treatment strategies remain limited. Given the prevalence of HIE and the associated fatality, further studies on its pathogenesis are warranted. Oxidative stress and neuroinflammatory injury are two important factors leading to brain tissue injury and nerve cell loss in HIE.

KRAS gene polymorphisms are associated with the risk of glioma: a two-center case-control study.

Background: Glioma, also known as neuroglioma, is the most common primary tumors of the central nervous system. Many previous studies have reported associations between RAS gene polymorphisms and multiple tumors. However, the role of RAS gene polymorphisms on glioma risk has not been investigated.

Efficient removal of acetochlor pesticide from water using magnetic activated carbon: Adsorption performance, mechanism, and regeneration exploration.

In this study, MnFeO supported activated carbon magnetic adsorbent (MnFeO@AC) was successfully prepared by a simple one-pot solvothermal method and used for the adsorption and removal of acetochlor from aqueous media. Results showed that MnFeO@AC with a MnFeO/AC mass ratio of 1:2 was characterized by good magnetism and high acetochlor adsorption capacity over a wide ranging pH, ionic strength, and humic acid concentration in an aqueous solution. Acetochlor was adsorbed on MnFeO@AC mainly by hydrogen bonding, π-π interactions, and pore-filling via film, intraparticle, and pore diffusion steps.

The association of miR34b/c and TP53 gene polymorphisms with Wilms tumor risk in Chinese children.

Wilms tumor is the most common pediatric malignancy in the kidney. The miR34b/c is a downstream target gene of the transcription factor p53. The important role of TP53 mutations, the methylation of miR34b/c, and the interaction between these two molecules in tumorigenesis have been well documented.

A mixed thermal elastohydrodynamic lubrication model of rotary lip seal.

Rotary lip seal is used in various applications where the rotation shaft needs to be sealed, such as hydraulic pumps, fuel pumps, camshafts, crankshafts, and so on. Many thermal elastohydrodynamic lubrication models of rotary lip seal have been introduced, and most of these models neglect the asperity contact. This article proposes a mixed thermal elastohydrodynamic lubrication model of rotary lip seal, in which the microstructure of sealing lip surface, influence of temperature on fluid viscosity, and deformation of lip surface, as well as the asperity contact, are taken into consideration.

The association of and gene polymerphisms with Wilms tumor risk in Chinese children.

Wilms tumor is considered to be the most common renal malignancy among children. RAN, a member of RAS superfamily, and its binding partner RANBP2 are related to the progression of multiple tumors. Nevertheless, the effects of the and gene polymorphisms on the tumorigenesis of Wilms tumor remain unclarified.

MYCN gene polymorphisms and Wilms tumor susceptibility in Chinese children.

Background: Wilms tumor, derived from embryonic cells, accounts for a large proportion of pediatric renal tumors. MYCN encoded by MYCN proto-oncogene, a member of the MYC family, is a BHLH transcription factor. It plays a critical role in tumorigenesis and predicts poor clinical outcomes in various types of cancer.