Adsorption and Removal of 2,4,6-Trinitrotoluene by a Glycoluril-Derived Molecular-Clip-Based Supramolecular Organic Framework.

A glycoluril-derived molecular-clip-based supramolecular organic framework (clip-SOF) with intrinsic porosity was prepared. The clip-SOF was used for the adsorption and removal of 2,4,6-trinitrotoluene (TNT) driven by noncovalent interactions. The efficiency of TNT removal by clip-SOFs is up to 88.

Molecule Empowerment and Crystal Desensitization: A Multilevel Structure-Property Analysis toward Designing High-Energy Low-Sensitivity Layered Energetic Materials.

Layered energetic materials (LEMs) can effectively balance energy and mechanical sensitivity, making them a current research focus in the field of energetic materials. However, the influence of the layered stacking pattern on impact sensitivity is still unclear, leading to the lack of advanced design strategies for high-energy low-sensitivity LEMs. Herein, we first utilize novel indicators such as maximum plane separation and hydrogen bond dimension to perform high-throughput screening on over 10 candidate structures, resulting in 17 target crystals.

Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and cancer risk: evidence based on 45,816 subjects.

MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to diverse functional consequences, including cancer development, by altering miRNA expression. Numerous studies have shown the association between miR-196a2 rs11614913 SNPs and cancer risk; however, the results are generally debatable and inconclusive, mainly due to limited statistical power.

SNCG shRNA suppressed breast cancer cell xenograft formation and growth in nude mice.

Background: Overexpression of breast cancer-specific gene 1 (SNCG) is associated with poor prognosis in advanced breast cancer patients. This study aimed to determine the effects of SNCG knockdown in breast cancer cells by using small hairpin RNA (shRNA).

Methods: Four different SNCG shRNA oligonucleotides were designed and chemically synthesized to construct mammalian expression vectors.