Publications by authors named "Xiaojuan Lin"

Background: In 1992, Hepatitis B vaccine was first recommended for routine neonatal immunization in China. This study aimed to estimate the prevalence of hepatitis B virus (HBV) infection in Shandong Province, eastern China (updating our previous study in 2014), and to help guide the efforts of hepatitis B elimination.

Methods: We determined prevalence of HBV infection from the remaining serum samples collected through a population-based survey, which was originally intended for a seroepidemiological survey of anti-SARS-CoV-2 antibodies conducted in 2023.

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Hepatoid adenocarcinoma of the ovary represents a rare and malignant extrahepatic tumor that shares morphological and immunophenotypic similarities with hepatocellular carcinoma. Due to the ambiguous histomorphology and aggressive behavior, the diagnosis and management of hepatoid adenocarcinoma of the ovary present unique challenges. Here, we present a 67-year-old woman with massive ascites and disseminated peritoneal implants at initial diagnosis.

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Objective: This study aimed to explore the association between the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the risk and severity of CHD among NAFLD patients.

Methods: This retrospective study included 278 patients with NAFLD and chest pain. The TG/HDL-C ratio was calculated and coronary angiography performed.

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To reveal the role of gut microbiota (GM) in the occurrence and development of idiopathic central precocious puberty (ICPP) using 16S rDNA sequencing and bioinformatics analysis. The Danazol-induced ICPP model was successfully constructed in this study. ZBDH and GnRHa treatments could effectively inhibit ICPP in rats, as manifested by the delayed vaginal opening time, reduced weight, decreased uterine organ coefficient, and decreased uterine wall thickness and corpus luteum number, as well as remarkably reduced serum hormone (LH, FSH, and E2) levels.

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Unlabelled: Mosquitoes carry a large number of known and unknown viruses, some of which could cause serious diseases in humans or animals. Metagenomic sequencing for mosquito viromes is crucial for understanding the evolutionary history of viruses and preventing emerging mosquito-borne diseases. We collected 1,598 mosquitoes belonging to four species from five counties in Shandong Province, China in 2021.

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Article Synopsis
  • The study aimed to explore how having a stillbirth affects various outcomes in subsequent pregnancies through a systematic review and meta-analysis of existing research.
  • Nineteen cohort studies with over 4.8 million participants were analyzed, focusing on the experiences of women with prior stillbirths compared to those with live births.
  • Results indicated that women with a history of stillbirth face significantly higher risks for issues like recurrent stillbirth, preterm birth, and low birth weight, among others, suggesting serious implications for future pregnancies.
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Objective: The aim of this study is to assess the efficacy and safety of poly (ADP-ribose) polymerase inhibitor (PARPi) as a maintenance therapy for patients with platinum-sensitive recurrent epithelial ovarian cancer (PSROC) at the largest center of gynecologic oncology in Western China.

Patients And Methods: The efficacy of PARPi was evaluated by progression-free survival (PFS) and overall survival (OS) in this real-world single-center retrospective cohort study conducted at West China Second University Hospital. The safety of PARPi was assessed using Common Terminology Criteria for Adverse Events Version 5.

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Human astroviruses (HAstVs) are a significant etiological agent of acute gastroenteritis in children. In order to investigate the circulation of HAstVs during the COVID-19 pandemic, a 2-year environmental surveillance was conducted in Jinan between 2020 and 2021. A total of 24 sewage samples were collected and concentrated.

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Noble metal electrocatalysts prepared by microbial methods have attracted extensive attention because of their environmental protection and easy preparation. However, the preparation of electrocatalysts by microbial methods has problems such as large nanoparticles size and low loading rate. In this study, the porous gel co-embedded with and alginate is prepared as the adsorption matrix to further enhance its mass transfer and adsorption efficiency.

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Article Synopsis
  • The study focuses on creating a secure strategy to combat immune evasion by refractory tumors and evolving SARS-CoV-2 variants using stem cell-based treatments.
  • Engineered spheroid-embryonoid stem cells (3D-E/BSC) were tested in aged rhesus monkeys to evaluate their potential against immune evasion from viral variants, while clinical trials were conducted with patients suffering from stage IV non-small cell lung cancer (NSCLC).
  • Results indicated that 3D-E/BSC not only enhanced immune responses but also remodeled the core immune system to resist both tumor and virus evasion, demonstrating long-term effectiveness and potential for improving survival rates in advanced cancer patients.
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Background: Patients with gynecologic cancers experience side effects of chemotherapy cardiotoxicity. We aimed to quantify cardiac magnetic resonance (CMR) markers of myocardial fibrosis in patients with gynecologic cancer and low cardiovascular risk who undergo chemotherapy.

Methods: This study is part of a registered clinical research.

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Rationale: The global prevalence of leprosy has decreased substantially, and cases of leprosy infection are extremely rare in China. In this report, we present a case of recurrent choriocarcinoma complicated by leprosy infection during chemotherapy.

Patient Concerns: A 24-year-old Chinese woman (gravida 3, para 2) presented to a local hospital with vaginal bleeding.

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Omono River virus (OMRV) is a newly reported, unclassified RNA virus in the family Totiviridae, which infects mosquitoes and bats. In this study, we report the isolation of an OMRV strain SD76 from Culex tritaeniorhynchus captured in Jinan city, China. The cytopathic effect was characterized by cell fusion on C6/36 cell line.

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Fetomaternal hemorrhage (FMH) result into severe, life-threatening fetal anemia and cause intrauterine death of the fetus. It is tough for an early diagnosis of FMH before pregnancy and few authors reported FMH in a twin pregnancy. Therefore, we reported a case of massive FMH.

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Article Synopsis
  • Next generation sequencing (NGS) was used to analyze sewage samples for enterovirus detection in the Weishan Lake region of China, assessing its effectiveness compared to traditional cell culture methods.
  • Fourteen sewage samples revealed 20 different enterovirus serotypes identified by NGS, surpassing the 9 types detected via cell culture, with the most common being Echovirus 11 and Coxsackievirus types.
  • This study highlights the diversity of enteroviruses in local populations and suggests that integrating NGS into environmental monitoring can enhance our understanding of virus circulation trends.
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Background: Whether low-dose alteplase is similar to standard-dose bridging alteplase prior to endovascular mechanical thrombectomy in patients with acute ischemic stroke (AIS) remains uncertain.

Aims: The aim of this study was to compare the efficacy and safety outcomes of low- versus standard-dose bridging alteplase therapy (BT) in patients with acute ischemic stroke (AIS) who are eligible for intravenous thrombolysis (IVT) within 4.5 h after onset.

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We present a near-real-time global gridded daily CO emissions dataset (GRACED) throughout 2021. GRACED provides gridded CO emissions at a 0.1° × 0.

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Background And Objective: Tacrolimus has become the first-line immunosuppressant for preventing rejection after heart transplantation. The present study aimed to investigate genetic variants and clinical factors affecting the variability of tacrolimus in Chinese Han heart transplant patients using a population pharmacokinetic approach.

Methods: The retrospective study included 53 hospitalized patients with 547 tacrolimus concentrations for analysis.

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Objective: Myocardial edema is an early manifestation of chemotherapy-related myocardial injury. In this study, we used cardiac magnetic resonance (CMR) T2 mapping to assess myocardial edema and its changes during chemotherapy for gynecologic malignancies.

Methods: We enrolled 73 patients receiving chemotherapy for gynecologic malignancies, whose the latest cycle was within one month before the beginning of this study, and 41 healthy volunteers.

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Objectives: The coxsackievirus A24 variant (CVA24v) has raised a remarkable concern because of its main etiological role in acute hemorrhagic conjunctivitis.

Methods: We conducted a retrospective study to summarize CVA24v isolated from acute hemorrhagic conjunctivitis outbreaks and acute flaccid paralysis surveillance in Shandong province, China during 1988-2020. Phylogenetic and phylogeographic methods based on the VP1 coding region were used to determine the CVA24v origin, spatiotemporal dynamics, and evolution.

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Building on near-real-time and spatially explicit estimates of daily carbon dioxide (CO) emissions, here we present and analyze a new city-level dataset of fossil fuel and cement emissions, Carbon Monitor Cities, which provides daily estimates of emissions from January 2019 through December 2021 for 1500 cities in 46 countries, and disaggregates five sectors: power generation, residential (buildings), industry, ground transportation, and aviation. The goal of this dataset is to improve the timeliness and temporal resolution of city-level emission inventories and includes estimates for both functional urban areas and city administrative areas that are consistent with global and regional totals. Comparisons with other datasets (i.

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Article Synopsis
  • Previous research indicated a link between heavy metals and congenital heart defects (CHDs), but there was limited information on titanium's effects; this study aimed to explore that connection.
  • The study analyzed data from a birth cohort at a hospital (2010-2012), focusing on titanium levels in maternal and umbilical cord blood to assess the risk of CHDs using logistic regression.
  • Results showed a significant association between higher titanium levels in pregnant women and increased risks of various CHDs in their offspring, indicating that titanium can cross the placental barrier and possibly contributes to heart defects.
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The aim is to study lung cancer with Lambert-Eaton myasthenic syndrome (LEMS) with clinical and electrical characteristics of physiology and prognosis. Fourteen LEMS patients with lung cancer were studied retrospectively. The data including demographics, clinical presentation, treatments, and prognosis from the medical records were analyzed.

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Sarcoplasmic/endoplasmic reticulum Ca ATPase 2 (SERCA2) is vital to maintain intracellular calcium homeostasis, and its redox Cys (C674) is the key to regulating activity. Our goal was to investigate whether the redox state of SERCA2 C674 is critical for cardiac fibrosis and the mechanisms involved. Heterozygous SERCA2 C674S knock-in (SKI) mice, in which half of C674 was substituted by serine, were used to mimic the partial loss of the reactive C674 thiol in pathological conditions.

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