Publications by authors named "Xiaoju Yuan"
Article Synopsis
- Neurocysticercosis (NCC) can be challenging to diagnose due to varying symptoms and imaging results, which may lead to increased mortality and disability without timely identification.
- A case of a 43-year-old male with recurrent headaches was diagnosed with NCC through metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid, which identified cysticercosis and confirmed with antibody tests.
- The mNGS method proved effective for NCC diagnosis, and successful treatment with anti-parasitic medication led to the resolution of symptoms, indicating its reliability for future cases.
Influenza A viruses (IAVs) and influenza B viruses (IBVs) cause annual epidemics in human populations with seasonal circulation spikes. Peptide AM58-66GL9 located at residues 58-66 of M1 protein of IAVs has been recognized as an immunodominant T cell epitope with HLA-A*0201 restriction and broadly used as a positive reference in influenza immunity. This peptide also almost completely overlaps with a nuclear export signal (NES) 59-68 in IAV M1, which explains the limited escape mutations under the T cell immune pressure in this region.
View Article and Find Full Text PDFBackground: T-37 can infect grapes and other fruit trees and cause root cancer. Given the pollution and damage of chemical agents to the environment, the use of biological control has become an important area of focus. L2 is a beneficial biocontrol strain isolated and identified in the laboratory, which has a good antibacterial effect on a variety of plant pathogens.
View Article and Find Full Text PDFRepeated influenza vaccination induces similar immune protection as first-time vaccination but with differing immune responses.
Influenza Other Respir Viruses
January 2023
Article Synopsis
- Recent influenza epidemics have been driven by H1N1, H3N2, and influenza B viruses, making annual vaccinations essential for preventing infections; however, their effectiveness with repeated vaccinations is unclear.
- A study was conducted during the 2019-2020 season, enrolling participants who were previously vaccinated and those who weren't, to analyze the immune response after receiving the inactivated quadrivalent vaccine (IIV4).
- Results showed that while repeated vaccinations led to higher immune responses for H3N2, the effectiveness was similar for both first-time and repeatedly vaccinated individuals regarding overall protection against the virus.
Application of metagenomic next-generation sequencing in the diagnosis of pulmonary invasive fungal disease.
Front Cell Infect Microbiol
October 2022
Background: Metagenomic next-generation sequencing (mNGS) is increasingly being used to detect pathogens directly from clinical specimens. However, the optimal application of mNGS and subsequent result interpretation can be challenging. In addition, studies reporting the use of mNGS for the diagnosis of invasive fungal infections (IFIs) are rare.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of coronavirus disease 2019 (COVID-19). Great international efforts have been put into the development of prophylactic vaccines and neutralizing antibodies. However, the knowledge about the B cell immune response induced by the SARS-CoV-2 virus is still limited.
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