Publications by authors named "Xiaojie Ruan"
Finding and constructing an osteogenic microenvironment similar to natural bone tissue has always been a frontier topic in orthopedics. We found that osteocytes are targeting cells controlling bone anabolism produced by PTH (JBMR 2017, PMID: 27704638), and osteocytes with activated Wnt signaling orchestrate bone formation and resorption (PNAS 2015, PMID: 25605937). However, methods for taking advantage of the leading role of osteocytes in bone regeneration remain unexplored.
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- MsrB1 is an enzyme involved in converting sulfoxides back to methionine and is found to be highly expressed in colorectal cancer (CRC) tissues and cell lines.
- MsrB1 knockdown in CRC cell lines led to decreased cell proliferation, migration, and invasion, while increasing apoptosis and altering protein levels related to cell adhesion and epithelial-mesenchymal transition.
- The study suggests that MsrB1 influences CRC tumorigenesis through the GSK-3β/β-catenin signaling pathway, highlighting its potential as a biomarker and therapeutic target for CRC treatment.