Publications by authors named "Xiaojie Liao"
Background: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.
Methods: We performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy.
Article Synopsis
- Genome-wide association studies (GWASs) have identified 35 genetic loci related to leprosy, but their combined effect only partially explains the disease risk, with unknown causal variants and genes.
- A new GWAS analyzing over 10,000 participants found 3 new and 15 previously reported risk loci, increasing the explained genetic heritability of leprosy from 23% to 38.5%.
- Fine-mapping analysis revealed 19 causal variants and 14 genes, primarily linked to immune regulatory elements, highlighting the importance of immune-related pathways in leprosy development.
Combination treatment with antibiotics and photodynamic therapy in refractory mycobacterium marinum infection: A case report.
Photodiagnosis Photodyn Ther
June 2023
Article Synopsis
- Mycobacterium marinum is a bacterium that can lead to skin infections, which usually require long-term treatment with multiple drugs.
- In some difficult cases, these treatments can cause issues like ineffectiveness, poor patient adherence, and sensitivity to the drugs.
- A reported case demonstrated that using a combination of antibiotics and photodynamic therapy over two years successfully cured a challenging Mycobacterium marinum infection.
Aim: To investigate the distribution of tubal endometriosis (EM) in the right and left sides and four parts of the fallopian tube.
Methods: A retrospective, cross-sectional study was conducted on patients with tubal EM at the Fourth Affiliated Hospital of Guangxi Medical University from October 2011 to September 2021. Chi-square and binomial tests were used for analysis.
Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected from healthy and GDM umbilical cords, and the endothelial properties were detected by flow cytometry.
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- * Researchers identified significant associations between specific SNPs (SFTPB rs7316 and SFTPC rs1124) and CF, along with several SNP-SNP interactions within and between SP genes.
- * The findings suggest that these genetic interactions could influence the progression and severity of pulmonary disease in CF patients, indicating a potential role for SPs as modifiers of the disease.
Objectives: Newly developed, direct-acting antiviral therapy is effective in over 90% of cases to eradicate hepatitis C virus infection. Direct-acting antiviral therapy is also effective in liver transplant recipients with recurrent hepatitis C virus infection. However, hepatic function after sustained virologic response in transplant recipients is unknown.
View Article and Find Full Text PDFIn Bacillus subtilis, the extracytoplasmic function (ECF) σ factors σ(M) , σ(W) and σ(X) all contribute to resistance against lantibiotics. Nisin, a model lantibiotic, has a dual mode of action: it inhibits cell wall synthesis by binding lipid II, and this complex also forms pores in the cytoplasmic membrane. These activities can be separated in a nisin hinge-region variant (N20P M21P) that binds lipid II, but no longer permeabilizes membranes.
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