Hydrovoltaic-Photoelectric Coupling Strategy Triggered a Robust Output Signal for High-Performance Self-Powered Electrochemical Sensing.

Hydrovoltaic self-powered electrochemical sensors hold significant potential for constructing wearable, portable, and real-time detection devices, but the low output signal due to the slow phase transition rate of water molecules and the intricate nature of integration limits their applications. In this work, a hydrovoltaic-photovoltaic coupling effect-enhanced self-powered electrochemical sensor was prepared by combining zinc oxide (ZnO) nanowire arrays with cerium-organometallic framework (Ce-MOF) materials, which greatly improved the electrical output of self-powered electrochemical systems and provided a new detection strategy for an efficient self-powered electrochemical sensing system. The heterojunction constructed by ZnO arrays and Ce-MOF could generate a built-in electric field under the action of light irradiation and promote the separation of the photocarriers.

Self-breathing strategy-enabled high-performance self-powered photoelectrochemical sensing by integrating with a perovskite AgBiO/TiC plasmonic heterojunction.

An innovative photocatalytic fuel cell (PFC)-based self-powered system was developed by integrating the perovskite AgBiO/TiC MXene plasmonic heterojunction with a self-breathing strategy, which was beneficial for developing high-performance self-powered photoelectrochemical biosensors.

Causal associations between kidney function and aortic valve stenosis: a bidirectional Mendelian randomization analysis.

Background: Aortic valve stenosis (AVS) is currently the most common heart valve disease. The results of observational studies on the incidence of AVS in the renal dysfunction population are contradictory due to the short follow-up period and different diagnostic criteria, etc. This study aimed to explore the causal relationship between kidney function and AVS using Mendelian randomization (MR) analysis.

Portable self-powered electrochemical aptasensor for ultrasensitive and real-time detection of microcystin-RR based on hydrovoltaic-photothermal coupling effect.

Coupling different energy harvesting technologies to obtain an excellent output signal is essential for the development of high-performance self-powered electrochemical sensors. Herein, a novel hydrovoltaic-photothermal coupling self-powered electrochemical aptasensing platform was designed for sensitive detection of microcystin (MC-RR) with a digital multimeter as a direct visual readout strategy. The straightforward ultrasonic method was employed to synthesize polyaniline (PANI) and bismuth oxybromide (BiOBr) nanosheets, which were then integrated as active components in a hydrovoltaic device.

Unveiling the Dynamic Evolution of Catalytic Sites in N-Doped Leaf-like Carbon Frames Embedded with Co Particles for Rechargeable Zn-Air Batteries.

The advancement of cost-effective, high-performance catalysts for both electrochemical oxygen reduction reactions (ORRs) and oxygen evolution reactions (OERs) is crucial for the widespread implementation of metal-air batteries. In this research, we fabricated leaf-like N-doped carbon frames embedded with Co nanoparticles by pyrolyzing a ZIF-L/carbon nanofiber (ZIF-L/CNF) composite. Consequently, the optimized ZIF-L/CNF-700 catalyst exhibit exceptional catalytic activities in both ORRs and OERs, comparable to the benchmark 20 % Pt/C and RuO.

Programming of in Situ Tumor Vaccines via Supramolecular Nanodrug/Hydrogel Composite and Deformable Nanoadjuvant for Cancer Immunotherapy.

The development of in situ tumor vaccines offers promising prospects for cancer treatment. Nonetheless, the generation of plenary autologous antigens in vivo and their codelivery to DC cells along with adjuvants remains a significant challenge. Herein, we developed an in situ tumor vaccine using a supramolecular nanoparticle/hydrogel composite (ANP/ALCD) and a deformable nanoadjuvant (PPE).

A bulit-in self-calibration ratiometric self-powered photoelectrochemical sensor for high-precision and sensitive detection of microcystin-RR.

A novel high-precision aptasensor of microcystin-RR (MC-RR) is developed based on a ratiometric self-powered photoelectrochemical platform. In detail, the defective MoS/TiC nanocomposite with good photoelectric activity was designed to serve as the photoanode of the sensor for enhancing the signal and improving the detection sensitivity. In order to effectively eliminate external interferences, the key point of this ratiometric device is the introduction of the spatial-resolved technique, which includes the detection section and the reference section, generating reference signals and response signals, respectively.

A zinc-air battery assisted self-powered electrochemical sensor for sensitive detection of microcystin-RR.

Building a high-performance sensing platform is the key to developing sensitive sensors. Herein, a highly sensitive self-powered electrochemical sensor (SPES) was constructed using a WO·HO film as the cathode prepared by a hydrothermal method and Zn as the anode, and it could be applied to sensitive detection of microcystin (MC-RR). The WO·HO film with a larger specific surface area could boost the oxygen reduction reaction (ORR), which could achieve signal amplification and significantly increase the sensitivity of the sensors.

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study.

Background: Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly accurate predictor of the aging process and associated health outcomes. This study aimed to explore the causal relationship between epigenetic clock and AVS by conducting a bidirectional Mendelian randomization (MR) analysis.

Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy.

To date, five siRNA-based medications have received clinical approval and have demonstrated remarkable therapeutic efficacy in treating various diseases. However, their application has been predominantly limited to liver-specific diseases due to constraints in siRNA delivery capabilities. In this study, we have developed a siRNA delivery system utilizing clinically approved mPEG--PLGA, a cationic lipid, and an ionizable lipid.

An ultrasensitive photo-driven self-powered aptasensor for microcystin-RR assay based on ZnInS/TiC MXenes integrated with a matching capacitor for multiple signal amplification.

A photo-driven self-powered aptasensor was constructed based on a matching capacitor and the ZnInS/TiC heterojunction as the photoanode and CuO as the photocathode in a dual-photoelectrode sensing matrix for multiple signal amplification for the ultrasensitive detection of microcystin-RR (MC-RR). The introduction of TiC MXene nanosheets on the photoanode surface can not only accelerate the transfer and separation of photoinduced electron/hole pairs, thus enhancing the output signal of the photo-driven self-powered system, but also provide a larger specific surface area for the immobilization of the bio-recognition unit aptamer. More importantly, for a portable and miniaturized device, a micro-workstation with the size of a universal serial bus (USB) disk and a novel short-circuit current access was proposed to capture the instantaneous output electrical signal for real-time data tracking.

Dietary fiber intake is positively associated with health-related quality of life in patients with hypertension: The mediating role of anxiety in mental component summary.

Few studies have focused on the exploration of the relationship between dietary fiber intake (DFI) and health-related quality of life (HRQoL) and its mediators in hypertensive patients. This study is a cross-sectional survey and the data were obtained from hypertensive patients from Suzhou, China. The DFI, office systolic blood pressure and diastolic blood pressure, anxiety and depression, and HRQoL were investigated.

Hydrovoltaic Effect Coupling with Capacitor Amplification: A Mode for Sensitive Self-Powered Electrochemical Sensing.

Self-powered electrochemical sensors, which can function without external electricity, are incredibly valuable in the realm of sensing. However, most of the present testing methods are normally confined to high environmental requirements, restricted lighting conditions, and temperature differences. Herein, an innovative self-powered electrochemical sensor was successfully developed based on hydrovoltaic effect coupling with capacitor amplification.

Ultrasensitive self-powered photoelectrochemical sensing for enrofloxacin detection by coupling piezoelectric effect with nonmetallic surface plasmon resonance based on ZnO nanorod arrays/WO.

Exploring efficient strategy for high-efficiency photoelectric conversion is quite important to design sensitive self-powered photoelectrochemical (PEC) sensing platform. This work designed a high performance self-powered PEC sensing platform by the integration of piezoelectric effect with localized surface plasmon resonance (LSPR) effect based on ZnO-WO heterostructures. Due to the fluid eddy induced piezoelectric effect by magnetic stirring, the piezoelectric semiconductor ZnO nanorod arrays (ZnO NRs) can facilitate the transfer of electrons and holes by generating piezoelectric potentials under external forces, thereby contributing to the performance of self-powered PEC platforms.

Impact of Hypocalcemia on the Prognosis of Patients with Acute Myocarditis.

Acute viral myocarditis is a serious complication of viral infectious diseases, including coronavirus disease 2019 (COVID-19). To better understand the pathogenesis of acute viral myocarditis, we retrospectively analyzed the incidence and prognostic significance of hypocalcemia among patients with acute myocarditis, most of whom were considered to have acute viral myocarditis. We retrospectively reviewed the demographic and clinical data of patients with clinically confirmed acute myocarditis treated in our hospital over a 13-year period from 2006 to 2019, including laboratory results, cardiac imaging findings, and clinical outcomes.

Highly efficient near-infrared electrochemiluminescence resonance energy transfer system for biosensing: Nonmetallic plasmon Mediated well-matched energy donor-acceptor pair.

Herein, a well-matched energy donor-acceptor pair strategy was designed to construct highly efficient NIR ECL-RET system. In detail, an ECL amplification system consisting of SnS quantum dots decorated TiC MXene nanocomposites (SnS QDs-TiC) as the energy donor were developed via a one-pot method, and the nanocomposites exhibited highly efficient NIR ECL emission due to the surface-defect effect generated by the oxygen-containing functional groups in MXene. Nonmetallic plasmon hydrated defective tungsten oxide nanosheets (dWO•HO) were utilized as energy acceptors because of its strong surface plasmon resonance effect in Vis-NIR absorption range.

Plasmonic heterostructure BiS/TiC with continuous photoelectron injection mediated near-infrared self-powered photoelectrochemical sensing.

Herein, a novel near-infrared (NIR) self-powered photoelectrochemical platform was constructed based on nonmetallic plasmon TiC MXene coupled with sulphur vacancy engineered BiS. The continuous photoelectron injection from BiS to TiC MXene induced a stable SPR effect and high photoelectric conversion efficiency, which is beneficial for developing high-performance NIR self-powered biosensors. As a proof of concept, a sensitive NIR self-powered sensor was constructed by conjunction with an aptamer using Microcystin-RR as a model analyte, which is one of the most common and toxic hepatotoxins released by cyanobacteria.

Self-powered photoelectrochemical aptasensor for sensitive detection of Microcystin-RR by integrating TiO/S-doped TiC MXene photoanode and MoS/S-doped TiC MXene photocathode.

Screening sufficient Fermi level differentiation of photoeletrodes is significantly meaningful for developing high-performance self-powered photoelectrochemical (PEC) sensors. In this work, a dual-photoelectrode self-powered system was fabricated for sensitive detection of Microcystin-RR (MC-RR) by integration of the TiO/S-doped TiC photoanode and MoS/S-doped TiC photocathode. The introduction of S-doped TiC nanosheets synergistically integrated with semiconductors (TiO and MoS) could generate the unique Schottky junctions, which could adjust the Fermi energy levels, facilitate the separation of electron-hole pairs and broaden light absorption, leading to high photoelectric conversion efficiency.

Greater Protection of Lower Dietary Carbohydrate to Fiber Ratio (CFR) against Poor Blood Pressure Control in Patients with Essential Hypertension: A Cross-Sectional Study.

(1) Background: Carbohydrate combined with dietary fiber (DF) applied as a surrogate marker of overall carbohydrate quality is a more essential determinant of cardiometabolic health. However, to date, no studies have applied this metric to analyze its associations with poor blood pressure control in hypertensive patients. (2) Methods: A cross-sectional design was implemented in one tertiary hospital and one community hospital in China.

Self-amplified chain-shattering cinnamaldehyde-based poly(thioacetal) boosts cancer chemo-immunotherapy.

The selective activation of stimuli-responsive polymers in the tumor microenvironment is a great concern to achieve intelligent cancer therapy, but most of them show inadequate response due to insufficient endogenous triggering agents. Herein, we rationally designed a reactive oxygen species (ROS)-responsive cinnamaldehyde (CA)-based poly(thioacetal), consisting of ROS-responsive thioacetal (TA) and ROS-generating agent CA, with self-amplified chain-shattering polymer degradation. The mechanism of self-amplified chain-shattering is that endogenous ROS as a triggering agent facilitates chain cleavage of TA with the release of CA, which in turn produces more ROS through mitochondrial dysfunction, resulting in an exponential polymer degradation cascade.

Optimized Cationic Lipid-assisted Nanoparticle for Delivering CpG Oligodeoxynucleotides to Treat Hepatitis B Virus Infection.

Purpose: Hepatitis B virus (HBV) infection is such a global health problem that hundreds of millions of people are HBV carriers. Current anti-viral agents can inhibit HBV replication, but can hardly eradicate HBV. Cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) are an adjuvant that can activate plasmacytoid dendritic cells (pDCs) and conventional dendritic cells (cDCs) to induce therapeutic immunity for HBV eradication.

Mucosal vaccine delivery: A focus on the breakthrough of specific barriers.

Mucosal vaccines can effectively induce an immune response at the mucosal site and form the first line of defense against microbial invasion. The induced mucosal immunity includes the proliferation of effector T cells and the production of IgG and IgA antibodies, thereby effectively blocking microbial infection and transmission. However, after a long period of development, the transformation of mucosal vaccines into clinical use is still relatively slow.

Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine.

Circadian factors likely influence the occurrence, development, therapy, and prognosis of cardiovascular diseases (CVDs). To determine the association between the heart rate (HR) diurnal parameters and CVD risks, we designed an analytical strategy to detect diurnal rhythms of HR using longitudinal data collected by clinically used Holter monitors and wearable devices. By combining in-house developed algorithms with existing analytical tools, we obtained trough phase and nocturnal variation in HR for different purposes.

Delivery of mRNA for regulating functions of immune cells.

Abnormal immune cell functions are commonly related to various diseases, including cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based therapy can regulate the functions of immune cells or assign new functions to immune cells, thereby generating therapeutic immune responses to treat these diseases. However, mRNA is unstable in physiological environments and can hardly enter the cytoplasm of target cells; thus, effective mRNA delivery systems are critical for developing mRNA therapy.