Publications by authors named "Xiaojia Ni"
Background: The aim of this study was to determine the therapeutic reference range of lurasidone, and to analyze the factors influencing the dose-corrected concentration of lurasidone in Chinese psychiatric patients, thereby providing a basis for the development of individualized dosing of lurasidone.
Methods: A retrospective analysis was conducted for hospitalized patients who had received lurasidone and undergone blood concentration monitoring from May 2022 to September 2023 at the Affiliated Brain Hospital of Guangzhou Medical University. Analyses were based on patient demographic data, treatment regimens, and administered drug concentrations.
Background: Insomnia is highly prevalent in stroke patients; however, there is no ideal intervention. This systematic review examined the effect and safety of Chinese herbal medicine (CHM) and acupuncture on sleep in adults with stroke.
Methods: Six databases were searched from inception to June 2023 to identify randomised controlled trials (RCTs).
Aims: This study aimed to investigate the association between the gut microbiota and the risk of stroke.
Methods: Faecal samples from 60 participants in South China, including 45 individuals with risk factors for stroke and 15 healthy controls, were collected and subjected to 16S rRNA sequencing. A bioinformatics analysis was performed to characterise the gut microbial diversity and taxonomic compositions at different risk levels (low, moderate, and high) of stroke.
Objectives: To analyze the factors affecting the concentrations of the active moiety of risperidone (RIS) and its active metabolite 9-hydroxyrisperidone (9-OH-RIS) in psychiatric outpatients taking immediate-release formulations.
Methods: This is a retrospective study on the therapeutic drug monitoring (TDM) data regarding RIS and 9-OH-RIS in adult psychiatric outpatients. TDM data with simultaneous RIS and 9-OH-RIS monitoring from March 2018 to February 2020 and relevant medical records (including dosage, dosage form, sex, age, diagnosis, combined medication, and comorbid disease) from 399 adult psychiatric outpatients (223 males and 176 females) were included in this study.
Background: Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC.
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- Alcohol use disorder (AUD) leads to chronic excessive drinking and withdrawal periods; diazepam is commonly used to treat alcohol withdrawal syndrome but the exact mechanisms of its effectiveness require further research.
- An animal model was created to study the effects of chronic ethanol exposure using advanced proteomic analysis and network analysis techniques to map protein interactions in the brain.
- Seven key hub proteins related to alcohol withdrawal and diazepam treatment were identified, with glutamatergic synapses emerging as a crucial pathway affected by alcohol use disorder and a potential target for new treatment strategies.
Article Synopsis
- Venlafaxine (VEN) is a common medication for treating depression and anxiety and is metabolized into an active form called O-desmethyl venlafaxine (ODV) after it is processed in the liver.
- The study aimed to create a population pharmacokinetic (PPK) model to analyze the characteristics of both VEN and ODV using data from a bioequivalence study involving healthy individuals and a larger group of psychiatric patients.
- The PPK modeling, performed with NONMEM software, showed that the metabolism of VEN and ODV follows a one-compartment model, and identified factors like mental health status and the medication amisulpride as significant influences on how these drugs are processed in the body, potentially aiding in personalized
Paroxetine is one of the most potent selective serotonin reuptake inhibitors (SSRIs) approved for treating depression, panic disorder, and obsessive-compulsive disorder. There is evidence linking genetic polymorphisms and nonlinear metabolism to the Paroxetine's pharmacokinetic (PK) variability. The purpose of the present study was to develop a population PK (PPK) model of paroxetine in Chinese patients, which was used to define the paroxetine's PK parameters and quantify the effect of clinical and baseline demographic factors on these PK characteristics.
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- Olanzapine is an atypical antipsychotic used for mental disorders, but there's limited pharmacokinetic data for Chinese pediatric patients aged 10 to 17 years, which raises questions about dosage variability.
- A study collected therapeutic drug monitoring data from 151 pediatric patients and developed a model using NONMEM software to simulate dosing regimens, targeting a concentration level of 20 ng/ml.
- The final model identified sex and concomitant valproate as significant factors affecting olanzapine clearance, suggesting specific daily dosages for male and female patients, which can assist physicians in dosage adjustments.
Introduction: Abnormal neurotransmission of glutamate and γ-aminobutyric acid (GABA) is a key characteristic of alcohol-related disorders. To track research output, we conducted a bibliometric analysis to explore the current status and trends in this field over the past decades.
Methods: Studies related to neurotransmitters and alcohol use disorder published in English from 2005-2021 were retrieved from the Web of Science Core Collection and Scopus databases.
Introduction: This study aims to summarize the available evidence and guideline/consensus recommendations for acupuncture and moxibustion in the treatment, prevention and rehabilitation of patients with coronavirus disease 2019 (COVID-19).
Methods: A scoping review was performed. Eight electronic databases and other related websites were searched.
Article Synopsis
- The study aimed to create a population pharmacokinetic model for escitalopram in Chinese psychiatric patients, focusing on factors affecting drug exposure.
- Data from 106 inpatients, including demographic data, CYP2C19 genotypes, and liver/kidney function, were analyzed using nonlinear mixed-effects modeling.
- Findings indicated that age and CYP2C19 genotype significantly influence escitalopram clearance, highlighting the need for individualized dosing, especially in older patients and poor metabolizers to avoid adverse effects.
Background And Purpose: Recently, there are a number of clinical studies on traditional Chinese medicine (TCM) for post-stroke sleep disorders (PSSDs). This study aimed to map the current clinical studies and identify gaps to inform future study agendas.
Methods: PubMed, Embase, Cochrane Library, and Chinese databases, including SinoMed, CNKI, and Wanfang, were searched for clinical studies on PSSDs treated with TCM from their inception to September 2021.
Background And Purpose: Overweight/obesity is a modified risk factor for stroke. This systematic review and meta-analysis aimed to assess the impact of different obesity phenotypes on stroke risk in adults.
Methods: The PubMed, Embase, and Cochrane Library databases were searched from their inception to 7 March 2021 to identify the prospective cohort studies investigating stroke risk among different metabolic overweight/obesity phenotypes.
A high-performance liquid chromatographic method coupled with triple quadrupole mass spectrometry (LC-MS/MS) for the analysis of blonanserin and its active metabolite, -desethyl blonanserin, in rat plasma has been developed and validated. The biological samples were treated by simple direct protein precipitation before separation on an Agilent Eclipse Plus C column (4.6 × 100 mm, 3.
View Article and Find Full Text PDFBackground: Acupuncture has been widely practiced for primary insomnia (PI). However, the relative benefit and harm among acupuncture therapies remain uncertain.
Objectives: To compare and evaluate the effect differences of multiple acupuncture therapies for patients with PI.
Acute infectious diseases constitute the most prevalent public health emergency (PHE) in China. Chinese herbal medicine (CHM) has long been used in the treatment of acute infections, but the overall evidence of its benefit and harm has not been comprehensively and systematically evaluated. We searched CBM, CNKI, Wanfang, PubMed, Cochrane Library, embase and preprint platforms to retrieve systematic reviews (SRs) on CHM for acute infectious.
View Article and Find Full Text PDFObjectives: To analyze the effectiveness and quality of stroke clinical practice guidelines (CPGs) published in recent years in order to guide future guideline developers to develop better guidelines.
Participants: No patient involved METHOD: PubMed, China Biology Medicine (CBM), Wanfang, CNKI, and CPG-relevant websites were searched from January 2015 to December 2019 by two researchers independently. The RIGHT (Reporting Items for Practice Guidelines in Healthcare) checklist was used to assess the reporting quality in terms of domains and items.
Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system. This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field.
View Article and Find Full Text PDFBackground: Low-dose amitriptyline (AMT) is an effective treatment for diarrhea-dominant irritable bowel syndrome (IBS-D). Its efficacy depends upon its serum concentration and the patient's CYP2C19 genotype.
Aims: To identify the association between serum AMT and nortriptyline (NT) concentration and CYP2C19 polymorphism and the clinical response in IBS-D patients.
Article Synopsis
- The study explores how pharmacokinetic variability in lamotrigine (LTG) affects dosing, aiming to predict dose-adjusted concentrations (C/D ratio) using machine learning (ML) techniques.
- A dataset of 1,141 therapeutic drug-monitoring measurements was divided into a training cohort (80%) and a validation cohort (20%), with various ML models developed and tested for effectiveness.
- The extra-trees regression algorithm proved to be the best model, achieving accurate predictions of the C/D ratio, which can aid clinicians in optimizing LTG doses to reduce adverse effects.
Objective: To assess the registration quality of traditional Chinese medicine (TCM) clinical trials for COVID-19, H1N1, and SARS.
Method: We searched for clinical trial registrations of TCM in the WHO International Clinical Trials Registry Platform (ICTRP) and Chinese Clinical Trial Registry (ChiCTR) on April 30, 2020. The registration quality assessment is based on the WHO Trial Registration Data Set (Version 1.
There is a crucial link between the gut microbiota and the host central nervous system, and the communication between them occurs a bidirectional pathway termed the "microbiota-gut-brain axis." The gut microbiome in the modern environment has markedly changed in response to environmental factors. These changes may affect a broad range of host psychiatric disorders, such as depression, by interacting with the host through metabolic, immune, neural, and endocrine pathways.
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