The impact of multidisciplinary collaborative bundled care on analgesia and sedation in ICU patients with endotracheal intubation.

Background: Effective analgesia and sedation management play a crucial role in reducing the intensity of coughing in patients with endotracheal intubation and improving clinical outcomes. However, current approaches are predominantly singular and lack comprehensive management strategies based on multidisciplinary collaboration. This study aims to evaluate the impact of multidisciplinary collaborative bundled care on analgesia and sedation in intensive care unit (ICU) patients with endotracheal intubation, providing evidence to inform clinical practice.

Identification of two QTLs for web blotch resistance in peanut (Arachis hypogaea L.) based on BSA-seq.

Background: Peanut (Arachis hypogaea L.) is a globally important oilseed and cash crop. Web blotch is one of the most important peanut foliar diseases, causing severe yield losses worldwide.

Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of L.: involved inhibiting inflammation and ferroptosis.

Rhizoma Dioscoreae Bulbiferae (HYZ) is a widely utilized herb in clinical practice, known for its significant biological activities. However, the associated hepatotoxicity poses limitations to its application. Our previous research indicated that the effective mitigation of HYZ-induced hepatotoxicity through the concoction with Radix Paeoniae Alba medicinal juice involves the incorporation of paeoniflorin (Pae) and a reduction in diosbulbin B (DB), the primary toxic compound in HYZ.

Associations of anxiety and depression with prognosis in chronic obstructive pulmonary disease: A systematic review and meta-analysis.

The associations between anxiety, depression, and the prognosis of COPD remain uncertain. The present study aims to investigate the associations of anxiety and depression with 30-day readmission rates and acute exacerbations of COPD (AECOPD). Four databases were searched to identify relevant studies published before 13 March 2024.

New Classifications of COPD Severity Based on Impulse Oscillometry: A SAIO Grade Base on ECOPD Cohort in China.

Background: Recently, the severities of chronic obstructive pulmonary disease (COPD) can also be assessed by impulse oscillometry (IOS). This study aimed to explore a new classification of severity of COPD based on IOS and associations with acute exacerbations (AE) in patients with COPD.

Methods: The data of our study were based on the baseline and 2-year follow-up data of a prospective cohort in China.

Preparation of a tetraethylenepentamine grafted magnetic chitosan bead for adsorption of Re(vii) from aqueous solutions.

A cross-linked magnetic chitosan bead (MCB) and tetraethylenepentamine grafted magnetic chitosan bead (TMCB) were synthesized using the water/oil (W/O) emulsion cross-linking method and characterized using scanning electron microscopy (SEM), vibrating-sample magnetometry (VSM) and Fourier transform infrared spectroscopy (FTIR). The saturation magnetization and remanent magnetization of TMCB were 7.09 emu g and 0.

Analysis of influencing factors and construction of nomogram prediction model of postoperative kinesiophobia in patients undergoing total knee arthroplasty.

Objective: To explore the influencing factors of kinesiophobia and to establish a nomogram prediction model.

Methods: A retrospective observational study was conducted in 354 patients who underwent TKA in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from December 2019 to December 2022. Sociodemographic characteristics, anesthesia methods, Tampa Scale for Kinesiophobia (TSK), numeric rating scale (NRS), hospital for special surgery (HSS), activities of daily living (ADL), and self-rating anxiety scale (SAS) were reviewed and analyzed.

Periprostatic fat magnetic resonance imaging based radiomics nomogram for predicting biochemical recurrence-free survival in patients with non-metastatic prostate cancer after radical prostatectomy.

Objective: To build and validate a periprostatic fat magnetic resonance imaging (MRI) based radiomics nomogram for prediction of biochemical recurrence-free survival (bRFS) of patients with non-metastatic prostate cancer (PCa) receiving radical prostatectomy (RP).

Methods: A retrospective study was conducted on 356 patients with non-metastatic PCa who underwent preoperative mpMRI followed by RP treatment at our institution. Radiomic features were extracted from both intratumoral region and the periprostatic fat region, which were segmented on images obtained through T2-weighted imaging (T2WI) and apparent-diffusion coefficient (ADC) imaging.

Disulfiram Alleviates MTX-Induced Pulmonary Fibrosis by Inhibiting EMT in Type 2 Alveolar Epithelial Cells.

Purpose: Methotrexate (MTX)-induced pulmonary fibrosis is associated with high morbidity and mortality, with limited treatment options available. This study investigates whether disulfiram (DSF) can mitigate MTX-induced pulmonary fibrosis and explores the underlying mechanisms.

Methods: Eight-week-old male mice were divided into control, DSF, MTX, and MTX+DSF groups and treated for 8 weeks.

Association of Exercise Tolerance with Respiratory Health Outcomes in Mild-to-Moderate COPD.

Previous studies have identified exercise intolerance in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD). The associations of exercise tolerance with lung function decline and acute exacerbation risk in mild-to-moderate COPD is unclear, especially in the community population. We evaluated exercise tolerance in mild-to-moderate COPD and analyzed its associations with respiratory health outcomes.

Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission.

Background: Bipolar disorder is a complex polygenic disorder that is characterized by recurrent episodes of depression and mania, the heterogeneity of which is likely complicated by epigenetic modifications that remain to be elucidated.

Methods: We performed transcriptomic analysis of peripheral blood RNA from monozygotic (MZ) twins discordant for bipolar disorder to identify disease-associated differentially expressed long noncoding RNAs (DE-lncRNAs), which were further validated in the PsychENCODE brain RNA-seq dataset. We then performed behavioral tests, electrophysiological assays, chromatin immunoprecipitation, and PCR to investigate the function of DE-lncRNAs in the mouse and cell models.

Numerical modeling and parametric analysis of temperature distribution in soil based on water content variation under radio frequency heating for in-situ thermal remediation.

Radio frequency heating (RFH) is recognized as an efficient and economical method for volatilizing organic pollutants from contaminated soils. Although some numerical simulations have been conducted to predict temperature changes during RFH, models that account for effects of water content (WC) variation on dielectric properties and temperature evolution in soil were rarely reported. To address this, a three-dimensional numerical model integrating electromagnetic-thermal conversion, heat transfer, and mass transfer was developed with coupling dynamic changes in WC and corresponding impacts on soil properties.

Machine learning-assisted source tracing in domestic-industrial wastewater: A fluorescence information-based approach.

An emergency water pollution incident poses a significant risk to the proper functioning of wastewater treatment plants, particularly in domestic-industrial integrated facilities. Source tracing is recognized as an effective method to mitigate ongoing impacts. Machine learning-assisted traceability is emerging as a more efficient and faster method compared to traditional methods.

Risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia.

Objective: To identify risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia and to construct a nomogram predictive model.

Methods: This retrospective study included 292 patients who underwent gastrointestinal endoscopy under acupuncture anesthesia at the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2020 to May 2023. Logistic regression analysis was used to identify risk factors for complications in patients undergoing gastrointestinal endoscopy under acupuncture anesthesia.

Dynamics of alternative polyadenylation in single root cells of .

Introduction: Single-cell RNA-seq (scRNA-seq) technologies have been widely used to reveal the diversity and complexity of cells, and pioneering studies on scRNA-seq in plants began to emerge since 2019. However, existing studies on plants utilized scRNA-seq focused only on the gene expression regulation. As an essential post-transcriptional mechanism for regulating gene expression, alternative polyadenylation (APA) generates diverse mRNA isoforms with distinct 3' ends through the selective use of different polyadenylation sites in a gene.

Catalyst-free regioselective sulfonylation of phenoxazine with sulfonyl hydrazides in HO/HFIP.

A facile catalyst-free sulfonylation of phenoxazine with sulfonyl hydrazides was efficiently developed in HO/HFIP without any catalyst. This metal- and catalyst-free protocol is suitable for aromatic and aliphatic reagents to afford the corresponding sulfones in moderate to high yields. A gram-scale experiment was performed to assess the practicability of the method.