Background: We aimed to identify and characterise the longitudinal patterns of multimorbidity associated with stroke.
Methods: We used an unsupervised patient-oriented clustering approach to analyse primary care electronic health records (EHR) of 30 common long-term conditions (LTC) in patients with stroke aged over 18, registered in 41 general practices in south London between 2005 and 2021.
Results: Of 849,968 registered patients, 9,847 (1.
The relationship between air pollution and the risk of systemic lupus erythematosus (SLE) remains inconclusive. Here, we investigated the associations between long-term exposure to ambient air pollutants and incident SLE, based on a cohort of 502,004 participants free of SLE at baseline from UK Biobank. During a median of 13.
View Article and Find Full Text PDFThis study investigated the associations of air pollution and residential greenspace with immune thrombocytopenic purpura (ITP) risk, along with their combined effects, in a cohort of 356,482 UK Biobank participants free of ITP at baseline. Ambient PM2.5, PMcoarse, PM10, NO2, and NOx exposures were estimated by land-use regression models and residential greenspace was calculated using land use data, defined as the percentage of outdoor greenspace surrounding each participant's home location.
View Article and Find Full Text PDFEpilepsy is characterized by abnormal neuronal firing in the brain. Several therapeutic strategies exist for epilepsy; however, several patients remain poorly treated. Therefore, the development of effective treatments remains a high priority in the field.
View Article and Find Full Text PDFAlginate oligosaccharides (AOs), derived from alginate degradation, exhibit diverse biological activities and hold significant promise in various fields. The enzymatic preparation of AOs relies on alginate lyases, which offers distinct advantages. In contrast to the conventional use of sodium alginate derived from brown algae as the substrate for the enzymatic preparation of AOs, AO preparation directly from brown algae is more appealing due to its time and energy efficiency.
View Article and Find Full Text PDFThe three stages of loess collapse are characterized by notable concealment and sudden onset due to the sudden nature of loess collapse and the prolonged duration of the peristaltic deformation stage. Traditional displacement monitoring methods struggle to detect early signals of instability and failure, leading to poor timeliness in disaster warnings. This project begins by examining non-force field information related to the loess collapse process.
View Article and Find Full Text PDFHeterogeneous cobalt-based catalysts are highly effective in activing peroxymonosulfate (PMS) and produce free radicals to deal with recalcitrant organic pollutants in water. However, unfeasible recyclability and gradual performance degradation remain challenging due to the easy agglomeration and leaching of active cobalt species. Herein, a strategy is proposed to construct stably anchored and highly dispersed Co sites on dual functional sulfonated covalent organic frameworks (COF-Co).
View Article and Find Full Text PDFIn this study, cobalt-doped hexagonal phase WO nanorods were prepared by a template-free hydrothermal method. The effects of varying the cobalt doping concentration on the microscopic morphology and electrochromic properties of hexagonal phase WO films were investigated. Films synthesized with the optimal cobalt element doping concentration demonstrate a notable improvement in their electrochromic properties compared to the pure hexagonal phase WO films.
View Article and Find Full Text PDFGenomics Proteomics Bioinformatics
December 2024
RNA methylation modifications influence gene expression, and disruptions of these processes are often associated with various human diseases. The common RNA methylation modification 5-methylcytosine (m5C), which is dynamically regulated by writers, erasers, and readers, widely occurs in transfer RNAs (tRNAs), messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), enhancer RNAs (eRNAs), and other non-coding RNAs (ncRNAs). RNA m5C modification regulates metabolism, stability, nuclear export, and translation of RNA molecules.
View Article and Find Full Text PDFThe intramolecular H-migration reaction of ROROO· radicals constitute a key class of reactions in the low-temperature combustion mechanism of ethers. Despite this, there is a dearth of direct computations regarding the potential energy surface and rate constants specific to ethers, especially when considering large molecular systems and intricate branched-chain structures. Furthermore, combustion kinetic models for large molecular ethers generally utilize rate constants derived from those of structurally similar alcohols or alkane fuels.
View Article and Find Full Text PDFStroke is a severe neurological disorder resulting from the rupture or blockage of blood vessels, leading to significant mortality and disability worldwide. Among the different types of stroke, ischemic stroke (IS) is the most prevalent, accounting for 70-80% of cases. Cell death following IS occurs through various mechanisms, including apoptosis, necrosis, and ferroptosis.
View Article and Find Full Text PDFBackground: Microvascular invasion (MVI) is associated with an unfavorable prognosis and early recurrence of hepatocellular carcinoma (HCC), which is the crucial pathological hallmark of immunotherapy. While microvascular invasion (MVI) in hepatocellular carcinoma (HCC) currently lacks a detailed single-cell analysis of the tumor microenvironment (TME), it holds significant promise for immunotherapy using immune checkpoint inhibitors (ICI).
Methods: We performed single-cell RNA sequencing (scRNA-seq) on 3 MVI positive (MVIP) and 14 MVI-negative (MVIN) tumor tissues, as well as their paired adjacent non-tumoral tissues.
Binary Nd-Ce oxides encapsuled in carbon nanotubes (CNTs) catalysts were synthesized and evaluated in the coupling reaction of ethylbenzene (EB) dehydrogenation and NO decomposition, a promising strategy for styrene (ST) production while mitigating greenhouse gas emissions. The optimized Nd - Ce@CNTs exhibited competitive catalytic performance with an EB conversion of 76 % and a ST selectivity of 71 % compared to Ce@CNTs, highlighting a synergic effect between Ce and Nd in the oxidation dehydrogenation of EB with NO as an oxidant (NO-ODEB). Characterization results indicated that Nd incorporation induced lattice distortions, evident in the expansion or contraction of Ce - O bonds surrounding Nd.
View Article and Find Full Text PDFThis study aimed to investigate the associations between carbohydrate intake and gout risk, along with interactions between genetic susceptibility and carbohydrates, and the mediating roles of biomarkers. We included 187,387 participants who were free of gout at baseline and completed at least one dietary assessment in the UK Biobank. Cox proportional hazard models were used to estimate the associations between carbohydrate intake and gout risk.
View Article and Find Full Text PDFSingle-atom-catalysts (SACs) with atomically dispersed sites on carbon substrates have attained great advancements in electrocatalysis regarding maximum atomic utilization, unique chemical properties, and high catalytic performance. Precisely regulating the electronic structure of single-atom sites offers a rational strategy to optimize reaction processes associated with the activation of reactive intermediates with enhanced electrocatalytic activities of SACs. Although several approaches are proposed in terms of charge transfer, band structure, orbital occupancy, and the spin state, the principles for how electronic structure controls the intrinsic electrocatalytic activity of SACs have not been sufficiently investigated.
View Article and Find Full Text PDFWalnuts ( L.), renowned for their nutritional potency, are a rich source of unsaturated fatty acids. Their regular intake plays a pivotal role in health maintenance and recuperation from a myriad of ailments.
View Article and Find Full Text PDFBackground: We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA).
Methods: The study included 1169 gout patients and 7029 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 and 2001-2018, respectively. The association between serum 25(OH)D and mortality was evaluated by Cox proportional hazard and restricted cubic spline models.
We aimed to investigate the species composition of a small mammal community and the prevalence of spp. in a typical endemic area of the Tibetan Plateau. One pika and five rodent species were identified based on the morphological characteristics of 1278 small mammal specimens collected during 2014-2019.
View Article and Find Full Text PDFChlorinated pollutants may follow distinct degradation pathways in anaerobic environments compared to aerobic settings. However, the understanding of the behaviors and fate of dichlorodiphenyltrichloroethanes (DDTs) under anaerobic conditions remains limited. To address this knowledge gap, we conducted a study on flooded soil samples collected from three typical paddy fields in China using an integrated approach of enantiomer-specific analysis and compound-specific stable carbon isotope analysis.
View Article and Find Full Text PDFUnderstanding the emission characteristics of particulate matter and associated heavy metals is essential for assessing their environmental and health impacts post-emission, as well as for identifying potential control technologies for the sources. Here, a field test was conducted at two advanced smelting plants equipped with comprehensive air pollution control devices. The particles emitted from different stages of lead and zinc smelting exhibited bi-modal size distributions, with peaks observed in PM and PM, respectively.
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