Different Effects of Fixed Appliances and Clear Aligners on the Microbiome and Metabolome of Dental Plaque.

Objective: This study aimed to uncover the microbial and metabolic changes in dental plaque during orthodontic treatments with fixed appliances (FAs) and clear aligners (CAs).

Materials And Methods: Twenty participants were grouped by the treatment modality they received, with 10 participants each in the FA and CA groups. Supragingival plaques were collected before orthodontic treatment (T0), after 1-3 months (T1) and more than 6 months (T2) of orthodontic treatment.

Unraveling the mechanism of norfloxacin removal and fate of antibiotics resistance genes (ARGs) in the sulfur-mediated autotrophic denitrification via metagenomic and metatranscriptomic analyses.

The co-contamination of antibiotics and nitrogen has attracted widespread concerns due to its potential harm to ecological safety and human health. Sulfur-driven autotrophic denitrification (SAD) with low sludge production rate was adopted to treat antibiotics laden-organic deficient wastewater. Herein, a lab-scale sequencing batch reactor (SBR) was established to explore the simultaneous removal of nitrate and antibiotics, i.

Injectable, pH-responsive hybrid hydrogels for the treatment of periodontitis.

Anti-inflammatory hydrogels have demonstrated great potential in the treatment of periodontitis. However, intelligent removal of reactive oxygen species (ROS) remains significantly challenging. In this study, a novel pH-responsive anti-inflammatory hydrogel was designed to treat periodontitis.

Case Report: A novel mutation in a patient with quadruple wild-type gastrointestinal stromal tumor.

In this report, we present a case study of a 64-year-old female who was diagnosed with gastrointestinal stromal tumors (GISTs) and subsequently developed liver metastases despite undergoing radical resection. Next-generation sequencing (NGS) assays indicated that the tumor lacked ( pathways, ) mutations, thereby classifying this patient as quadruple WT GIST (qGIST). Treatment with imatinib was initiated, and after 2.

Effects of Hypoxic Environment on Periodontal Tissue through the ROS/TXNIP/NLRP3 Inflammasome Pathway.

There is low evidence for the possible association between obstructive sleep apnea-hypopnea syndrome (OSAHS) and periodontitis, necessitating further research. This study was aimed at investigating this association. For the in vitro study, 8-day-old Wistar rats were divided into the unilateral nasal obstruction group (UNO) and the sham surgery group (SHAM).

The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders.

Autism spectrum disorders (ASD) are neurodevelopmental disorders with changes in the gut and oral microbiota. Based on the intimate relationship between the oral microbiota and oral mucosal immunity, this study aimed to investigate changes in salivary immunoglobulin A (IgA) level in ASD and the underlying mechanism for any such changes. We recruited 36 children diagnosed with ASD and 35 normally developing children and measured their salivary IgA content using enzyme-linked immunosorbent assay (ELISA).

Adsorptive Removal of Low-Concentration Cr(VI) in Aqueous Solution by Mg-Al Layered Double Oxides.

To explore the adsorption removal mechanism of Mg-Al layered double oxides (LDOs) for low-concentration (≤ 5 mg L) Cr(VI), the adsorption kinetics, adsorption isotherms and its influencing factors were studied by batch experiments. Cr(VI) adsorption reached equilibrium after 6, 11 and 15 h for initial Cr(VI) concentrations of 1, 3 and 5 mg L, respectively, and the final adsorption efficiency exceeded 99.0%.

Iodine enrichment and the underlying mechanism in deep groundwater in the Cangzhou Region, North China.

The lack of information on the origin and behavior of iodine in deep groundwater restricts the development and use of groundwater resources. To address this issue, the Cangzhou region in the eastern North China Plain (NCP) was selected for a case study. In total, 296 deep groundwater samples were collected, their iodine concentrations were determined, and the distribution characteristics of iodine concentrations were analyzed.

NH-N/NO-N ratio controlling nitrogen transformation accompanied with NO-N accumulation in the oxic-anoxic transition zone.

Although nitrogen (N) transformations have been widely studied under oxic or anoxic condition, few studies have been carried out to analyze the transformation accompanied with NO-N accumulation. Particularly, the control of mixed N species in N-transformation remains unclear in an oxic-anoxic transition zone (OATZ), a unique and ubiquitous redox environment. To bridge the gap, in this study, OATZ microcosms were simulated by surface water and sediments of a shallow lake.

Circadian transcription factor Dbp promotes rat calvarial osteoprogenitors osteogenic differentiation through Kiss1/GnRH/E2 signaling pathway loop.

To determine the mechanism by which D-site-binding protein (Dbp) regulates rat calvarial osteoprogenitors (OPCs) osteogenic differentiation. α-Smooth muscle actin (α-SMA) + rat calvarial OPCs were extracted and purified using immunomagnetic beads. Cells were transduced with Dbp-lentivirus and divided into Dbp knockdown, Dbp overexpression and vehicle groups.

Characteristics and metabolic pathway of the bacteria for heterotrophic nitrification and aerobic denitrification in aquatic ecosystems.

The present study investigated the nitrogen removal characteristics and metabolic pathway of bacteria in aquatic ecosystem, with a focus on heterotrophic nitrification and aerobic denitrification. The bacteria demonstrated significant heterotrophic nitrification and aerobic denitrification capacity. The highest ammonium-N, nitrate-N, and nitrite-N removal efficiencies were 95.

The correlation analyses of bacterial community composition and spatial factors between freshwater and sediment in Poyang Lake wetland by using artificial neural network (ANN) modeling.

As one of the most important components of the lake ecosystem, microorganisms from the freshwater and sediment play an important role in many ecological processes. However, the difference and correlation of bacterial community between these two niches were not clear. This study investigated the diversity of microbial community of freshwater and sediment samples from fifteen locations in Poyang Lake wetland.

Preparative Purification of Bioactive Compounds from and Evaluation of Its Antiosteoporosis Effect.

To understand the material basis and underlying molecular machinery of antiosteoporosis activity of the (FCI), the consequences of ethanol extract on the bone loss in mice induced due to ovariectomy (OVX) was evaluated. Also, the antiosteoporosis fraction obtained from the FCI ethanol extract was isolated and purified using a preparative high-speed countercurrent chromatography (HSCCC). The impact of the compounds was investigated on osteoblast proliferation and differentiation.

[Condylar morphological changes before and after orthodontic treatment for angle Class I malocclusion adult patients].

Purpose: To evaluate the diagnostic sensitivity and specificity of panoramic radiography in detection of maxillary teeth roots projecting into the maxillary sinus.

Methods: Paired panoramic radiographs and cone-beam CT (CBCT) images of maxilla from 110 subjects were analyzed. 42 males and 68 females (15~36 years old) with the second molars erupted completely were included.

[Cephalometric evaluation of the effects of pendulum appliance on various vertical growth patterns].

Objective: The aim of this study was to investigate the effects of the pendulum appliance in treating dental Class II patients with various vertical growth patterns.

Methods: The samples (n = 30) were divided into three groups equally based on their FMA. Pretreatment and post-treatment cephalometric radiographs were taken to measure the changes.