Cushing Syndrome Is Associated With Gut Microbial Dysbiosis and Cortisol-Degrading Bacteria.

Context: Cushing syndrome (CS) is a severe endocrine disease characterized by excessive secretion of cortisol with multiple metabolic disorders. While gut microbial dysbiosis plays a vital role in metabolic disorders, the role of gut microbiota in CS remains unclear.

Objective: The objective of this work is to examine the alteration of gut microbiota in patients with CS.

The genomic landscape of reference genomes of cultivated human gut bacteria.

Culture-independent metagenomic studies have revolutionized our understanding of the gut microbiota. However, the lack of full genomes from cultured species is still a limitation for in-depth studies of the gut microbiota. Here we present a substantially expanded version of our Cultivated Genome Reference (CGR), termed CGR2, providing 3324 high-quality draft genomes from isolates selected from a large-scale cultivation of bacterial isolates from fecal samples of healthy Chinese individuals.

Draft Genome Sequence of Fusobacterium vincentii CNGBCC1850030, Isolated from Healthy Human Feces.

Fusobacterium vincentii usually inhabits the oral cavity and plays an important role in periodontal diseases. Here, we report the draft genome sequence of strain CNGBCC1850030, isolated from healthy human feces.

A Bacterial Genome and Culture Collection of Gut Microbial in Weanling Piglet.

The microbiota hosted in the pig gastrointestinal tract are important to health of this biomedical model. However, the individual species and functional repertoires that make up the pig gut microbiome remain largely undefined. Here we comprehensively investigated the genomes and functions of the piglet gut microbiome using culture-based and metagenomics approaches.

Complete genome sequence of the highly Mn(II) tolerant Staphylococcus sp. AntiMn-1 isolated from deep-sea sediment in the Clarion-Clipperton Zone.

Staphylococcus sp. AntiMn-1 is a deep-sea bacterium inhabiting seafloor sediment in the Clarion-Clipperton Zone (CCZ) that is highly tolerant to Mn(II) and displays efficient Mn(II) oxidation. Herein, we present the assembly and annotation of its genome.

[Bacterial diversity in deep-sea sediments from two stations in the east Pacific polymetallic nodule province].

Objective: The objective of this study was to assess bacterial diversity in sediment samples from two stations (WBC1305 and WBC1316A) in the Pacific polymetallic nodule province.

Methods: The environmental total DNAs were extracted, and 6 bacterial 16S rRNA gene libraries were generated from 6 sediment layers. The Shannon diversity index and Simpson dominance index were calculated for each bacterial community and then compared.

Complete Genome Sequence of Hemolysin-Containing Carnobacterium sp. Strain CP1 Isolated from the Antarctic.

Carnobacterium sp. strain CP1 was isolated from Antarctic sandy soil and predicted to be a novel species belonging to the genus Carnobacterium Herein, we report the complete genome sequence, which consists of a circular 2,605,518-bp chromosome and an 8,883-bp plasmid with G+C contents of 38.13% and 31.