Publications by authors named "Xiaohan Rong"
Article Synopsis
- - Researchers are exploring how the protein ELAVL1 influences glycolysis in nasopharyngeal carcinoma cells via the HMGB3/β-catenin pathway, noting that ELAVL1 is often overexpressed in these tumors.
- - The study utilized various methods, including mouse models and biochemical assays, to show that knocking down ELAVL1 reduces cancer cell growth and glycolytic activity, while its interaction with HMGB3 helps stabilize HMGB3 mRNA to enhance β-catenin activity.
- - The findings suggest that targeting the ELAVL1-HMGB3-β-catenin interaction could provide a new therapeutic strategy for treating nasopharyngeal carcinoma by disrupting this metabolic pathway.
Regulatory T (Treg) cells are involved in the antiviral immune response in patients with coronavirus disease 2019 (COVID-19); however, whether Treg cells are involved in the neutralizing antibody (nAb) response remains unclear. Here, we found that individuals who recovered from mild but not severe COVID-19 had significantly greater frequencies of Treg cells and lower frequencies of CXCR3+ circulating T follicular helper (cTfh) cells than healthy controls. Furthermore, the frequencies of Treg and CXCR3+ cTfh cells were negatively and positively correlated with the nAb responses, respectively, and Treg cells was inversely associated with CXCR3+ cTfh cells in individuals who recovered from mild COVID-19 but not in those with severe disease.
View Article and Find Full Text PDFObjective: To evaluate the effectiveness of home-based exercise to treat nonspecific shoulder pain (NSSP).
Data Sources: MEDLINE, Embase, Cumulative Index to Nursing and Allied Health, Cochrane Controlled Register of Trials, and Physiotherapy Evidence Database were searched from inception to January 2022.
Study Selection: Independent reviewers selected randomized controlled trials that compared the effects of home-based exercise alone with no treatment or other conservative treatments in individuals with nonsurgical painful shoulder disorders.