Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.

The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets of AD with depression. We confirmed a positive correlation between AD and depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related to AD.

Female mice exposed to varying ratios of stearic to palmitic acid in a high-fat diet during gestation and lactation shows differential impairments of beta-cell function.

Aims: While emerging evidence implicates an abnormal stearic-to-palmitic acid ratio in saturated fats in beta-cell dysfunction, their gestational/lactational impacts remain underexplored. This study evaluates the differential transient and long-lasting effects of high-fat diets with contrasting stearic-to-palmitic acid ratios on maternal beta-cell function.

Materials And Methods: Female mice were fed high-fat diets with high/low stearic-to-palmitic acid ratios during gestation/lactation, followed by a recovery period and subsequent exposure to an obesogenic diet.

Spatial equity and factors that influence the distribution of elderly care institutions in China.

Background: With China becoming an aging society, the number of elderly care institutions (ECIs) is continuously increasing in response to the growing population of older persons. However, regional disparities may lead to an uneven distribution of ECIs, which could affect equity in care. This study identified the limiting factors in the development of ECIs across different regions, thereby promoting equity in accessing care for the older population.

Forgiveness in the HPA axis: The roles of cumulative genetic effects and cortisol reactivity in trait and situational forgiveness.

Trait and situational forgiveness are vital coping mechanisms and stress responses in the face of interpersonal transgressions. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in regulating these strategies in response to such transgressions. Building on this foundation, Study 1 examined the impact of cumulative genetic effects of the HPA axis (i.

Transcriptomic reprogramming and epigenetic regulation underlying pollination-dependent and auxin-induced fruit set in tomato.

The transition from flower to fruit, naturally triggered by flower pollination and known as fruit set, is instrumental for plant reproduction, seed formation, and crop yield. Notably, this developmental process can also proceed in the absence of flower fertilization, although it remains unclear whether pollination-dependent and pollination-independent fruit sets undergo similar transcriptomic reprogramming. Genome-wide transcriptomic profiling of the flower-to-fruit transition, either pollination-induced or triggered by auxin treatment, shows that both types of triggers modulate the expression of a common large set of genes primarily expressed in maternal tissues.

Development and psychometric evaluation of the Nursing Teacher Emotional Labor Scale.

Background: Nursing teachers, as a group with high emotional labor, report heightened levels of negative emotions and burnout. Focusing on the emotional labor of nursing teachers is essential for improving their emotional well-being and job satisfaction. However, there is a lack of assessment tools specifically tailored to the emotional labor of nursing teachers.

Development and validation of machine learning models based on stacked generalization to predict psychosocial maladjustment in patients with acute myocardial infarction.

Background: Psychosocial maladjustment threatens the recovery of patients with acute myocardial infarction (AMI), and early identification of patients with psychosocial maladjustment may facilitate provision of reference to targeted interventions. The aims of this study were to: (1) identify key factors influencing patient psychosocial maladjustment, and (2) develop a machine learning predictive model based on Stacked Generalization.

Methods: Young and middle-aged patients with AMI (n = 734) were recruited from two tertiary hospitals (Center I and Center II) in Guangdong Province.

MiR-133b-3p attenuates angiotensin II-induced cardiac hypertrophy through the inhibition of apoptosis by targeting .

MicroRNAs (miRNAs) have emerged as essential regulators that play important roles in the development of multiple systems. Recent studies have identified significant roles for miRNAs in the progression of cardiac hypertrophy. This study aims to investigate the effects of miR-133b-3p on angiotensin II (Ang II)-induced cardiac hypertrophy and apoptosis, as well as explore its underlying mechanisms.

East Asian expatriate football players and national team success: Chinese, Japanese, and South Korean players in Europe (2000-2024).

This study investigated the influence of Chinese, Japanese, and South Korean football players' participation in European leagues on their national teams' FIFA rankings from 2000 to 2024. Utilizing data from 22,972 matches featuring 392 players across 36 European leagues and 12 tournaments or cup competitions, survival and conditional process analyses were conducted to explore the relationships between expatriate player counts, appearances, playing time, and FIFA rankings. The results demonstrated a significant correlation between the number of expatriate players, particularly in top-tier leagues, and national team rankings.

Relationship Between the 2019 Ridgecrest, California, 7.1 Earthquake and Its 6.4 Foreshock Sequence.

The 2019 Ridgecrest 7.1 earthquake has received significant attention due to its complex fault activity. It is also noticeable for its 6.

AaMYB61-like and AabHLH137 jointly regulate anthocyanin biosynthesis in Actinidia arguta.

Background: Red Actinidia arguta has recently become highly popular because of its red appearance resulting from anthocyanin accumulation, and has gradually become an important breeding direction. However, regulators involved in anthocyanin biosynthesis have not been fully characterized in A. arguta.

Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the mA modification of calsequestrin 2 in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a medical condition characterized by cardiac remodeling and dysfunction in individuals with diabetes mellitus. Sarcoplasmic reticulum (SR) and mitochondrial Ca overload in cardiomyocytes have been recognized as biological hallmarks in DCM; however, the specific factors underlying these abnormalities remain largely unknown. In this study, we aimed to investigate the role of a cardiac-specific long noncoding RNA, D830005E20Rik (Trdn-as), in DCM.

TBX3 is Essential for Zygotic Genome Activation and Embryonic Development in Pigs.

The pluripotency-related T-box family transcription factor TBX3 maintains mESC self-renewal and plays a key role in the development of several tissues, including the heart, mammary glands, limbs, and lungs. However, the role of TBX3 during porcine preimplantation embryo development remains unclear. In our research, TBX3 was knocked down by injecting dsRNA to explore the function of TBX3.

Predicting 28-day all-cause mortality in patients admitted to intensive care units with pre-existing chronic heart failure using the stress hyperglycemia ratio: a machine learning-driven retrospective cohort analysis.

Chronic heart failure (CHF) poses a significant threat to human health. The stress hyperglycemia ratio (SHR) is a novel metric for accurately assessing stress hyperglycemia, which has been correlated with adverse outcomes in various major diseases. However, it remains unclear whether SHR is associated with 28-day mortality in patients with pre-existing CHF who were admitted to intensive care units (ICUs).

Phthalates in the environment of China: A scoping review of distribution, anthropogenic impact, and degradation based on meta-analysis.

Phthalates (PAEs) are a group of endocrine-disrupting environmental chemicals (EEDs) that pose significant risks to human health. PAEs are widespread in various environmental media, including air, dust, water, and soil, and are subject to both horizontal and vertical migration. Human activities significantly influence the distribution of PAEs, yet current research on this relationship remains limited.

Human Health Risk Assessment of Chlorinated Hydrocarbons in Groundwater Based on Multi-Pathway Analysis.

The rapid development of the global chemical industry has led to widespread groundwater contamination, with frequent pollution incidents posing severe threats to water safety. However, there has been insufficient assessment of the health risks posed by chlorinated hydrocarbon contamination in groundwater around chemical industrial parks. This study evaluates the chlorinated hydrocarbon contamination in groundwater at a chemical park and conducts a multi-pathway health risk assessment, identifying the key risk pollutants.

SNF7 Presents Excellent Antibacteria and Anti-Inflammation Properties in Mouse Diarrhea Induced by .

() is a common pathogen that causes diarrhea in newborns and animals. Antibiotics are typically used to treat bacterial diarrhea, a global intestinal health issue. Probiotics have gained interest as a potential substitute for antibiotics in the management of -induced diarrhea and present novel therapeutic options.

Weighted Echo State Graph Neural Networks Based on Robust and Epitaxial Film Memristors.

Hardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph-structured data. However, most amorphous/polycrystalline oxides-based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra-low power consumption.

Tetrahydroberberrubine improves hyperlipidemia by activating the AMPK/SREBP2/PCSK9/LDL receptor signaling pathway.

Hyperlipidemia is a major risk factor for hypertension, coronary heart disease, diabetes and stroke, triggering an intensified research efforts into its prevention and treatment. Tetrahydroberberrubine (THBru) is a derivative of berberine (BBR) that has been shown to have higher bioavailability and lower toxicity compared to its parent compound. However, its impact on hyperlipidemia has not been fully explored.

Dignity in nursing homes: A qualitative descriptive study of older adults' experiences.

Background: With the deepening trend of global aging, the issue of dignity of older adults has received widespread attention. The research on the dignity of older adults in nursing homes in China has only just begun, and it is necessary to further explore the dignity experience of older adults in nursing homes.

Research Objective: To investigate the thematic features of dignity experiences of older adults residing in nursing homes in mainland China.

Solvents and their hydrogen bonding properties as general considerations in carbon dioxide reduction by molecular catalysts.

Improvements to the understanding of how reaction conditions influence the performance of molecular electrocatalysts are important. There exists a wide range of solution conditions that are used in the investigation of the properties and performance of electrocatalysts, from the choice of solvent or electrolyte to the identity and nature of other additives, like Brønsted acids. Herein, we demonstrate how the choice of solvent can have a significant impact on the observed rate constants for CO-to-CO conversion by a series of rhenium(I) diimine complexes.

[Salidroside alleviates high glucose and ethanol-induced pyroptosis in insulinoma cells].

This study established a pyroptosis injury model by stimulating insulinoma cells(INS-1) of rats with high glucose(HG) and observed the impact of additional ethanol(ET) exposure on cell pyroptosis, as well as the intervention effect of salidroside(SAL). INS-1 cells were cultured and divided into a normal control group(NG), an HG group, an HG + ET(100 mmol·L~(-1)) group, and an HG + ET + SAL(1-100 μmol·L~(-1)) group. After 72 hours of treatment, cell viability was assessed using the cell counting kit-8(CCK-8) assay.

The influential factors of depression among caregivers of children with Cleft Lip and/or Palate: a path analysis based on diathesis-stress theoretical model.

Background: Depression is the most common psychological phenomenon among caregivers of children with Cleft Lip and/or Palate and affects the quality of life, treatment satisfaction, children's self-esteem and parent-child relationship. However, Existing studies have limited explanations for the mechanisms that lead to depression in caregivers of children with Cleft Lip and/or Palate. The present study aimed to identify factors influencing depression among caregivers of children with Cleft Lip and/or Palate and to provide a reference point and new ideas for future research.