DNA Reaction Network Central Controller for Dynamic Spatiotemporal Logical Assembly and Its Application for Rational Design of Fluorometric/Electrical Biosensing.

This work introduces a fluorometric/electrical dual-biosensing logic system based on a DNA reaction network (DRN). This system was used to spatiotemporally modulate the kinetic behavior of DNA nanostructures. The system, acting as a programmable and modulative central controller introduced to implement, enabled the monitoring of the target gliotoxin.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific aptamer (Apt) and the walker (Walker DNA) are integrated into TWJs.

A rapid and sensitive sandwich assay for the detection of Alicyclobacillus acidoterrestris in apple juice based on magnetosome immunomagnetic separation combined with quantum dots immunoassay technology.

The contamination of apple juice by Alicyclobacillus acidoterrestris (A. acidoterrestris) can cause significant economic losses. Therefore, developing a rapid and sensitive method for detecting A.

Hypoglycemic effect and intestinal transport of phenolics-rich extract from digested mulberry leaves in Caco-2/insulin-resistant HepG2 co-culture model.

Phenolics of mulberry (Morus alba L.) leaves (MLs) have potential anti-diabetic effects, but they may be chemically modified during gastrointestinal digestion so affect their biological activity. In this study, an in vitro digestion model coupled with Caco-2 monolayer and Caco-2/insulin-resistant HepG2 coculture model were used to study the transport and hypoglycemic effects of phenolics in raw MLs (U-MLs) and solid-fermented MLs (F-MLs).

Antibacterial properties of hexanal-chitosan nanoemulsion against Vibrio parahaemolyticus and its application in shelled shrimp preservation at 4 °C.

Vibrio parahaemolyticus has been considered as the leading pathogen associated with seafood-borne disease. Hexanal possesses antibacterial property but the hydrophobicity and volatility limit its application. The purpose of this study was to prepare hexanal-chitosan nanoemulsion (HCN), investigate its antibacterial ability against V.

Ratiometric fluorescence aptasensor for the detection of patulin in apple juice based on the octahedral UiO-66-TCPP metal-organic framework and aptamer systems.

Patulin (PAT) is a potentially harmful mycotoxin to human health and is known to contaminate apple juice. In this work, we developed a ratiometric fluorescence aptasensor using tetrakis(4-carboxyphenyl)porphyrin (HTCPP)-treated octahedral UiO-66-NH (defined as UiO-66-TCPP) to detect PAT. This 2-aminoterephthalic acid and HTCPP functionalized metal-organic framework showed multiple adsorption effects (hydrogen bonding and π-π stacking) on the aptamer (Apt) and served as a quenching material.

Infiltration of porcine pancreatic lipase into magnetic hierarchical mesoporous UiO-66-NH metal-organic frameworks for efficient detoxification of patulin from apple juice.

Patulin (PAT) is a mycotoxin known to globally contaminate fruits. The economic losses and health hazards caused by PAT desires a safe and efficient strategy for detoxifying PAT. Here, a magnetic core-shell hierarchical mesoporous metal-organic framework (FeO@HMUiO-66-NH) was synthesized via a salt-assisted nanoemulsion guided assembly method.

The bioaccessibility, bioavailability, bioactivity, and prebiotic effects of phenolic compounds from raw and solid-fermented mulberry leaves during in vitro digestion and colonic fermentation.

The bioaccessibility and bioactivity of phenolic compounds in mulberry leaves (MLs) relate to the digestion process. This study was aimed at investigating the release of phenolic compounds, as well as the potential bioactivities of raw MLs (UF-MLs) and solid-fermented MLs (F-MLs) during in vitro digestion and colonic fermentation. Antioxidant activities and phenolic compounds released in the digested extracts are shown in decreasing order of location: intestinal > oral > gastric.

Influence of encapsulated and eugenol on the physicochemical properties and microbial community of fresh-cut apples.

This study aimed to evaluate the application of encapsulated . and eugenol as potential biocontrol agents in sliced apples. The combined encapsulated .

Enrichment and Distribution of Selenium in MRS-7: Impact on Its Biochemical Composition, Microstructure, and Gastrointestinal Survival.

Lactic acid bacteria can convert selenium (Se) from inorganic to organic and elemental forms, but the distribution and existence form of organic Se in the bacteria are not clear after Se enrichment, and the effects of selenization on the growth and nutritional value of strains also need to be studied. In this study, MRS-7 could absorb up to 67% of inorganic Se and convert most of it into organic Se; about 75% of organic Se was selenoprotein, 2.7% was Se-polysaccharide, and 4.

Potential protective mechanism of Tibetan kefir underlying gut-derived liver injury induced by ochratoxin A.

Tibetan kefir (TK) is a good source of probiotics and has antioxidative, anti-inflammatory, and gut microbiota-regulating properties. Ochratoxin A (OTA) causes liver injury through the gut microbiota. It is unclear whether TK has differential effects on the gut-liver axis and whether these effects can alleviate liver injury induced by OTA.

Label-free fluorescence aptasensor for the detection of patulin using target-induced DNA gates and TCPP/BDC-NH mixed ligands functionalized Zr-MOF systems.

Patulin (PAT) is an unsaturated lactone mycotoxin primarily produced by Penicillium expansum and Aspergillus clavatus. Given the potential health risks and economic losses associated with PAT, the rapid detection of PAT using fluorescent aptasensors is of significant importance in evaluating food safety. However, it easily increases the cost and complexity caused by signal labeling.

Protective effects of Tibetan kefir in mice with ochratoxin A-induced cecal injury.

Ochratoxin A (OTA) is reported to cause intestinal damage following ingestion of contaminated foods. Tibetan kefir (TK) is a fermented dairy product that possesses antioxidant, anti-inflammatory, and gut microbiota-regulating properties. However, it is not clear if TK can alleviate OTA-associated intestinal toxicity.

Selenium-Enriched MRS-7 Alleviates Patulin-Induced Jejunum Injuries in Mice and Its Possible Mechanisms.

Patulin (PAT) is a common mycotoxin. Oral ingestion of PAT could damage the intestinal mucosa. Both selenium and probiotics can alleviate intestinal damage, but there are few reports on selenium-enriched probiotics.

Recent developments in antifungal lactic acid bacteria: Application, screening methods, separation, purification of antifungal compounds and antifungal mechanisms.

Fungal contamination of food, which causes large economic losses and public health problems, is a global concern. Chemical methods are typically used in the food industry to inhibit the growth of spoilage fungus, but there are several drawbacks of chemical methods. Thus, the development of consumer-friendly and ecologically sustainable biological preservation technology has become a hot spot in food research.

An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide.

The authors constructed a voltammetric zearalenone (ZEN) aptasensor based on use of porous platinum nanotubes, gold nanoparticles (p-PtNTs/AuNPs) and thionine (Thi) labelled graphene oxide (GO). The p-PtNTs were synthesized in-situ based on tellurium nanowires as sacrificial templates. Subsequently, thiol-modified aptamers were self-assembled on the AuNPs that had been electrodeposited on the surface of the modified electrode.

Previously unidentified Indonesian Throughflow pathways and freshening in the Indian Ocean during recent decades.

The Earth has experienced a global surface warming slowdown (GSWS) or so-called "global warming hiatus" since the end of the 20 century. The GSWS was marked by a La Niña-like decadal cooling in the Pacific Ocean that subsequently generated an increase in the transfer of Pacific waters into the Indian Ocean via the Indonesian Throughflow (ITF). How the Pacific water spreads through the interior of the Indian Ocean and the impact of these decadal ITF transport changes on the Indian Ocean water mass transformation and circulation remain largely unknown.

Warming in the Agulhas Region during the Global Surface Warming Acceleration and Slowdown.

The Agulhas Region gains more heat during the global surface warming slowdown than acceleration period. Yet, mechanisms that cause excessive heat accumulation in this region remain largely unknown. We investigate the underlying physical processes and examine their influence on ocean heat changes in the last three decades.

The Subpolar North Atlantic Ocean Heat Content Variability and its Decomposition.

The Subpolar North Atlantic (SPNA) is one of the most important areas to global climate because its ocean heat content (OHC) is highly correlated with the Atlantic Meridional Overturning Circulation (AMOC), and its circulation strength affects the salt transport by the AMOC, which in turn feeds and sustains the strength of the AMOC. Moreover, the recent global surface warming "hiatus" may be attributed to the SPNA as one of the major planetary heat sinks. Although almost synchronized before 1996, the OHC has greater spatial disparities afterwards, which cannot be explained as driven by the North Atlantic Oscillation (NAO).

Decadal Western Pacific Warm Pool Variability: A Centroid and Heat Content Study.

We examine several characteristics of the Western Pacific Warm Pool (WP) in the past thirty years of mixed interannual variability and climate change. Our study presents the three-dimensional WP centroid (WPC) movement, WP heat content anomaly (HC) and WP volume (WPV) on interannual to decadal time scales. We show the statistically significant correlation between each parameter's interannual anomaly and the NINO 3, NINO 3.