Exploring the role of diarylheptanoids derived from turmeric in trapping methylglyoxal with natural deep eutectic solvents.

Methylglyoxal (MGO) is a reactive carbonyl compound that forms advanced glycation end products (AGEs), which are associated with diseases such as diabetes, cancer, and Alzheimer's disease. Turmeric, which contains bioactive diarylheptanoids, has compounds like curcumin that can trap MGO and inhibit the formation of AGEs. However, diarylheptanoids suffer from poor stability and solubility, complicating their use in standard methods.

Single Administration of AAV-mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2-Induced Lysosomal Dysfunction in Hair Cells.

Haploinsufficiency of the ATP6V1B2, a subunit of V-ATPases, underlies genetic disorders including Dominant deafness-onychodystrophy (DDOD), deafness, onychodystrophy, osteodystrophy, mental retardation and seizures (DOORS), and Zimmermann-Laband syndromes, all characterized by congenital hearing loss and onychodystrophy. Effective therapies for ATP6V1B2-associated hearing loss remain elusive. The study generates a hair cell-specific knockout mouse (Atp6v1b2;Atoh1) recapitulating the human phenotypes, with pathological features including hair cell loss and abnormal lysosomal morphology and function.

Multifunctional Polymer Interphase with Fast Kinetics for Ultrahigh-rate Zn Metal Anode.

Polymer interphase on Zn anodes obviates dendrite growth and significant side reactions including corrosion and hydrogen evolution in aqueous zinc ion batteries (AZIBs), however has drawbacks of slow kinetics and large overpotential for Zn plating/stripping that prevent practical application especially under high-rate conditions. Here, a multifunctional polymer interphase with fast kineticsis reported, using poly(phenazine-alt-pyromellitic anhydride) (PPPA) as an electrolyte additive. PPPA, with linear π-conjugated structure and enriched polar pyridine (conjugated cyclic -C=N-) and carbonyl (C=O) groups, preferentially adsorbs on the Zn anode to form a stable solid-electrolyte interphase (SEI) layer in situ.

Synergistic Effects of FeO/N-Doped Porous Carbon Nanospheres for Enhanced Oxygen Reduction Reaction.

Designing transition metal oxide (TMO)/porous carbon composite materials for the oxygen reduction reaction (ORR) is a promising strategy in high-performance fuel cell technology. In this study, we used the isolation effect and pore-creating properties of Zn to fabricate a composite material comprising ultrasmall FeO particles anchored on hierarchically N-doped porous carbon nanospheres. This material, referred to as CPZ-Fe, serves as an efficient ORR electrocatalyst in alkaline fuel cells.

Formulation, characterization, and evaluation of curcumin-loaded ginger-derived nanovesicles for anti-colitis activity.

Plant-derived nanovesicles have gained attention given their similarity to mammalian exosomes and advantages such as low cost, sustainability, and tissue targeting. Thus, they hold promise for disease treatment and drug delivery. In this study, we proposed a time-efficient method, PEG 8000 combined with sucrose density gradient centrifugation to prepare ginger-derived nanovesicles (GDNVs).

Alisma plantago-aquatica polysaccharides ameliorate acetaminophen-induced acute liver injury by regulating hepatic metabolic profiles and modulating gut microbiota.

Acetaminophen (APAP) has emerged as a predominant contributor to acute liver failure (ALF) in United States. Alismatis rhizoma, a commonly used traditional herbal medicine, contains small molecular components with extensive hepatoprotective activity. However, the specific role of Alismatis rhizoma polysaccharide (ARP) in liver protection remains unclear.

Tailoring Intrinsic Oxygen Vacancies in P3-Type NaMnMgO to Enhance Oxygen Redox Activity.

Integrating oxygen redox reactions with transition metal redox reactions offers a promising strategy to double or triple the energy density for large-capacity battery cathodes. In this study, we have introduced intrinsic oxygen vacancies (V) into a P3 layered cathode to modulate the electronic structure of O atoms and enhance oxygen redox activity. Rietveld-refined X-ray diffraction (XRD), X-ray absorption spectroscopy (XAS), and X-ray photoelectron spectroscopy confirm the successful creation of V in NaMnMgO (OV-NMM).

[Deep transfer learning radiomics model based on temporal bone CT for assisting in the diagnosis of inner ear malformations].

To evaluate the diagnostic efficacy of traditional radiomics, deep learning, and deep learning radiomics in differentiating normal and inner ear malformations on temporal bone computed tomography（CT）. A total of 572 temporal bone CT data were retrospectively collected, including 201 cases of inner ear malformation and 371 cases of normal inner ear, and randomly divided into a training cohort（=458） and a test cohort（=114） in a ratio of 4∶1. Deep transfer learning features and radiomics features were extracted from the CT images and feature fusion was performed to establish the least absolute shrinkage and selection operator.

Modified EBP-bFGF targeting endogenous renal extracellular matrix protects against renal ischemia-reperfusion injury in rats.

Acute kidney injury (AKI) is a life-threatening disease primarily caused by renal ischemia-reperfusion (I/R) injury, which can result in renal failure. Currently, growth factor therapy is considered a promising and effective approach for AKI treatment. Basic fibroblast growth factor (bFGF), an angiogenic factor with potent activity, efficiently stimulates angiogenesis and facilitates regeneration of renal tissue.

Bi-functional KIT-PR1P peptides combine with VEGF to protect ischemic kidney in rats by targeting to Kim-1.

Introduction: Acute kidney injury (AKI) was a disease with a high mortality mainly caused by renal ischemia/reperfusion injury (I/R). Although the current non-targeted administration of vascular endothelial growth factor (VEGF) for AKI had been revealed to facilitate the recovery of renal I/R, how to targeted deliver VEGF and to retain it efficiently in the ischemic kidney was critical for its clinical application.

Methods: In present study, bi-functional KIT-PR1P peptides were constructed which bond VEGF through PR1P domain, and targeted ischemic kidney through KIT domain to interact with biomarker of AKI-kidney injury molecule-1 (Kim-1).

Exploration of a Novel Noninvasive Prenatal Testing Approach for Monogenic Disorders Based on Fetal Nucleated Red Blood Cells.

Background: Due to technical issues related to cell-specific capture methods, amplification, and sequencing, noninvasive prenatal testing (NIPT) based on fetal nucleated red blood cells (fNRBCs) has rarely been used for the detection of monogenic disorders.

Methods: Maternal peripheral blood was collected from 11 families with hereditary hearing loss. After density gradient centrifugation and cellular immunostaining for multiple biomarkers, candidate individual fetal cells were harvested by micromanipulation and amplified by whole-genome amplification (WGA).

Improved protein structure prediction with trRosettaX2, AlphaFold2, and optimized MSAs in CASP15.

We present the monomer and multimer structure prediction results of our methods in CASP15. We first designed an elaborate pipeline that leverages complementary sequence databases and advanced database searching algorithms to generate high-quality multiple sequence alignments (MSAs). Top MSAs were then selected for the subsequent step of structure prediction.

Imbalance of Vaginal Microbiota and Immunity: Two Main Accomplices of Cervical Cancer in Chinese Women.

Objective: To explore the correlation of female vaginal microbiota and immune factors with cervical cancer.

Methods: The distribution pattern difference of vaginal microbiota of four groups of women (cervical cancer, HPV-positive CIN, HPV-positive non-CIN, and HPV-negative groups) were compared by microbial 16S rDNA sequencing. The protein chip was used to detect the composition and changes of the immune factors in the four groups.

Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.

Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients' health and lives. Mitochondria are core organelles for the maintenance of myocardial tissue homeostasis, and their impairment and dysfunction are considered major contributors to the pathogenesis of various CVDs, such as hypertension, myocardial infarction, and heart failure. However, the exact roles of mitochondrial dysfunction involved in CVD pathogenesis remain not fully understood.

Digital economy, spatial spillover and industrial green innovation efficiency: Empirical evidence from China.

The digital economy is pushing more efficient and greener production and innovation processes, as well as quickening the mobility of production factors, which would have a critical impact on improving industrial green innovation efficiency. Based on the panel data of 30 Chinese provinces from 2005 to 2019, this study established a comprehensive index system to assess the level of provincial digital economy development, and adopted the SBM-DEA model including non-expected output to evaluate industrial green innovation efficiency, then adopted the I and I to test whether there is spatial autocorrelation, followed by the spatial Durbin model (SDM) and the mediating effect test model to investigate the direct impact, spatial spillover effect and indirect transmission mechanism of the digital economy on industrial green innovation efficiency. The results show that: both the development level of the digital economy and industrial green innovation efficiency show positive spatial autocorrelation; The digital economy not only has a significant direct role in promoting industrial green innovation efficiency but also has a spatial spillover effect; The digital economy can improve industrial green innovation efficiency by promoting manufacturing structure upgrading and stimulating enterprises' green technology innovation.

Three-in-one oxygen-deficient titanium dioxide in a pomegranate-inspired design for improved lithium storage.

Defects engineering has played an ever-increasing important role in electrochemistry, especially secondary lithium batteries. TiO is regarded as a promising anode due to its attractive cycling stability, low volume strain and great abundance, while challenges of intrinsic poor electrical and ionic conductivity remain to be addressed. Herein, we report a three-in-one oxygen vacancy (V)-involved pomegranate design for TiO/C composite anode, which provides highly improved electrical conduction, shortened Li pathway and promoted Li redox.

FADD as a key molecular player in cancer progression.

Cancer is a leading disease-related cause of death worldwide. Despite advances in therapeutic interventions, cancer remains a major global public health problem. Cancer pathogenesis is extremely intricate and largely unknown.

The FOXO family of transcription factors: key molecular players in gastric cancer.

Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third leading cause of cancer-related death with an oncological origin. Despite its decline in incidence and mortality in recent years, GC remains a global public problem that seriously threatens patients' health and lives. The forkhead box O proteins (FOXOs) are a family of evolutionarily conserved transcription factors (TFs) with crucial roles in cell fate decisions.

FOXO3a in cancer drug resistance.

Cancer is one of the major causes of death and a significant obstacle to increasing life expectancy worldwide. Chemotherapy remains the first-line adjuvant therapeutic option for all stages of cancer, and it can effectively improve patients' prognosis in the short term. However, its long-term effect on extending patient survival is limited due to the emergence of drug resistance.

Rapid screening of illegal additives in functional food using atmospheric pressure solids analysis probe coupled to a portable mass spectrometer.

Pharmaceutical drugs like Sildenafil are illegally added to functional food such as nutritional supplements and herbal remedies to deliver drugs without a regular prescription to consumers. Rapid screening of illegal additives is desirable for the public security department. The seized samples are often large in number and unknown in composition; methods are needed for qualitative screening of unknown samples.

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug Resistance.

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, with high recurrence and mortality rate. Chemotherapy, including 5-fluorouracil (5-FU), adriamycin (ADR), vincristine (VCR), paclitaxel (PTX), and platinum drugs, remains one of the fundamental methods of GC treatment and has efficiently improved patients' prognosis. However, most patients eventually develop resistance to chemotherapeutic agents, leading to the failure of clinical treatment and patients' death.

Ultrafast Room-Temperature Synthesis of Self-Supported NiFe-Layered Double Hydroxide as Large-Current-Density Oxygen Evolution Electrocatalyst.

Water splitting is a promising sustainable technology to produce high purity hydrogen, but its commercial application remains a giant challenge due to the kinetically sluggish oxygen evolution reaction (OER). In this work, a time- and energy-saving approach to directly grow NiFe-layered double hydroxide (NiFe-LDH) nanosheets on nickel foam under ambient temperature and pressure is reported. These NiFe-LDH nanosheets are vertically rooted in nickel foam and interdigitated together to form a highly porous array, leading to numerous exposed active sites, reduced resistance of charge/mass transportation and enhanced mechanical stability.