Publications by authors named "Xiaogang Wu"

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  • Triple-negative inflammatory breast cancer (TN-IBC) is the most aggressive form of breast cancer, and its specific genetic and immune characteristics are not well understood.
  • This study conducted extensive genomic analyses of TN-IBC tumors from a phase II clinical trial, comparing them to stage III triple-negative non-inflammatory breast cancer (TN-non-IBC) samples.
  • Key findings revealed that TN-IBC tumors have unique features, such as a lower mutation load and the presence of immune components that may hinder chemotherapy response, indicating a need for further research to identify potential biomarkers and treatment targets.
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Plastic mulch is widely recognized as a significant contributor to microplastics (MPs) pollution in agricultural soil. However, its direct impact on remote areas with low population density remains uncertain due to multiple pollution sources. This study aims to investigate MPs pollution and its risks regarding agricultural soil in the Qinghai Tibetan Plateau (QTP) in China.

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  • The study explores the biomechanical performance of a newly designed spinal fusion cage compared to traditional titanium and PEEK cages, highlighting the drawbacks of stress shielding and poor bone ingrowth associated with the former materials.
  • Using finite element analysis, the new combined cage showed a 9.5% increase in strain capacity and reduced endplate and fusion stresses by 12% and 17%, respectively, during dynamic movements.
  • The findings indicate that the combined cage may improve fusion stability and reduce adverse effects tied to titanium cages, offering insights for better clinical cage designs in spinal fusion surgeries.
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  • Bacterial cooperation, especially between anammox and symbiotic bacteria, is crucial for efficient nitrogen removal in wastewater treatment, particularly under varying NH4-N concentrations.
  • Research showed that anammox bacteria benefit from antioxidants like vitamin B6 produced by symbiotic bacteria, which help them cope with high NH4-N and fluctuating oxygen levels.
  • When faced with increased NH4-N, anammox bacteria reduce amino acid supply to save metabolic energy, leading some bacterial generalists to specialize and improve microbial community stability and functionality.
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  • The study examines the impact of RAS mutations on long-term survival in patients with colorectal liver metastases (CRLM) who have undergone hepatectomy.
  • Researchers analyzed data from 399 CRLM patients, focusing on specific mutations in KRAS and NRAS genes, and used statistical methods to evaluate survival rates.
  • The findings indicate that KRAS G12 mutations correlate with better survival outcomes, while KRAS Q61 and NRAS Q61 mutations are linked to worse survival, suggesting these mutations can help identify high-risk patients for targeted treatment strategies.
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  • Anammox bacteria are typically anaerobic but this study shows they can grow in aerobic conditions, producing more nitrate without losing total nitrogen.
  • The bacteria utilize nitrite oxidation and hydrazine dehydrogenation for carbon fixation while their hydrazine dehydrogenase is inhibited in aerobic settings.
  • Findings also indicate that various metabolic pathways are upregulated in aerobic conditions, highlighting the bacteria's adaptation to oxygen through antioxidative enzymes like bacterioferritins.
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Inappropriate planting patterns can increase pollutant concentrations and threaten human health. This study examined three greening patterns (trees, trees + hedges, and hedges) using the ENVI-met model to evaluate the different effects of various planting patterns on PM dispersion within an idealized 3D street canyon under three typical wind directions. Results showed that street greenbelts alter the PM concentration field within canyons, and the horizontal and vertical distribution characteristics of PM under different wind directions were significantly different.

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Clarifying the matching degree and the trade-offs and synergies between supply and demand of ecosystem services is of significance for scientific division of management zoning and sustainable urban development. We calculated the supply and demand of ecosystem services at the sub-district (town) scale of Taiyuan based on multi-source data, explored the coldspots and hotspots area of the supply-demand ratio and the trade-offs and synergies of six ecosystem services using the Getis-Ord Gi tool and correlation analysis, and proposed strategies based on the regional characteristics of natural-resource and socio-economy. Results showed the distribution of the supply and demand of ecosystem services had a spatial heterogeneity.

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  • Increasing heat stress in cities due to climate change negatively affects human well-being and daily activities, particularly in areas known as street canyons where people spend most of their time.
  • The study utilized the ENVI-met model to analyze how factors like the aspect ratio of streets (height to width ratio) and tree spacing contribute to pedestrian thermal comfort in different street orientations in Taiyuan, China.
  • Findings revealed that a lower aspect ratio (H/W = 1.0) and closer tree spacing (TS = 6 m) significantly improve thermal comfort by reducing temperatures, especially in east-west oriented streets, providing valuable information for urban design and planning.
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Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution and microenvironment in ACC remains limited. We investigated the intratumoral microbiomes of 50 ACC tumor tissues and 33 adjacent normal tissues using 16S rRNA gene sequencing.

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Passion fruit (Passilora edulis), known as the "king of fruit juices", is popular in southern China (Yuan et al. 2019). Stem base rot is a devastating disease of passion fruit commonly caused by several Fusarium spp.

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As a novel biological wastewater nitrogen removal technology, simultaneous nitrification and denitrification (SND) has gained increasing attention. Iron, serving as a viable material, has been shown to influence nitrogen removal. However, the precise impact of iron on the SND process and microbiome remains unclear.

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Recently, it is reported that bacterial communication coordinates the whole consortia to jointly resist the adverse environments. Here, we found the bacterial communication inevitably distinguished bacterial adaptation among different species in partial nitrification reactor under decreasing temperatures. We operated a partial nitrification reactor under temperature gradient from 30 °C to 5 °C and found the promotion of bacterial communication on adaptation of ammonia-oxidizing bacteria (AOB) was greater than that of nitrite-oxidizing bacteria (NOB).

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The role of ray radiation from the sunlight acting on organisms has long-term been investigated. However, how the light with different wavelengths affects nitrification and the involved nitrifiers are still elusive. Here, we found more than 60 % of differentially expressed genes (DEGs) in nitrifiers were observed under irradiation of blue light with wavelengths of 440-480 nm, which were 13.

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Soil contamination by Cr(VI) has attracted widespread attention globally in recent years, but it remains a significant challenge in developing an environmentally friendly and eco-sustainable technique for the disposal of Cr(VI)-contaminated soil. Herein, a sustainable cyclic soil washing system for Cr(VI)-polluted soil remediation and the recovery of washing agents using biochar supported nanoscale zero-valent iron (nZVI-BC) was established. Citric acid (CA) was initially screened to desorb Cr(VI) from contaminated soil, mobilizing Cr from the highly bioaccessible fractions.

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Plants possess intricate defense mechanisms to resist cadmium (Cd) stress, including strategies like metal exclusion, chelation, osmoprotection, and the regulation of photosynthesis, with antioxidants playing a pivotal role. The application of nitrogen (N) and phosphorus (P) fertilizers are reported to bolster these defenses against Cd stress. Several studies investigated the effects of N or P on Cd stress in non-woody plants and crops.

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Osteochondral allograft (OCA) transplantation involves grafting of natural hyaline cartilage and supporting subchondral bone into the cartilage defect area to restore its biomechanical and tissue structure. However, differences in biomechanical properties and donor-host matching may impair the integration of articular cartilage (AC). This study analyzed the biomechanical properties of the AC in different regions of different sites of the knee joint and provided a novel approach to OCA transplantation.

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The prevention, control and treatment of cerebral aneurysm (CA) has become a common concern of human society, and by simulating the biomechanical environment of CA using finite element analysis (FEA), the risk of aneurysm rupture can be predicted and evaluated. The target models of the current study are mainly idealized single-layer linear elastic cerebral aneurysm models, which do not take into account the effects of the vessel wall structure, material constitution, and structure of the real CA model on the mechanical parameters. This study proposes a reconstruction method for patient-specific trilaminar CA structural modeling.

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Recently, photogranules composed of bacteria and microalgae for carbon-negative nitrogen removal receive extensive attention worldwide, yet which type of bacteria is helpful for rapid formation of photogranules and whether they depend on signaling communication remain elusive. Varied signaling communication was analyzed using metagenomic method among bacteria and microalgae in via of two types of experimentally verified signaling molecule from bacteria to microalgae, which include indole-3-acetic acid (IAA) and N-acyl homoserine lactones (AHLs) during the operation of photo-bioreactors. Signaling communication is helpful for the adaptability of bacteria to survive with algae.

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  • * This study models the complete osteochondral unit with poroelastic materials, revealing that as osteoarthritis progresses, alterations in the size and shape of defects impact fluid flow behavior, potentially affecting injury progression.
  • * Findings indicate that larger and thicker defects lead to decreased interstitial fluid pressure and velocity, with nutrient loss occurring as the osteochondral unit becomes more permeable, contributing to the understanding of fluid flow mechanisms in osteoarthritis.
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Background: Chemoradiation (CRT) may modulate the immune milieu as an in-situ vaccine. Rapid dose delivery of brachytherapy has unclear impact on T-cell repertoires. HPV-associated cancers express viral oncoproteins E6/E7, which enable tracking antigen/tumor-specific immunity during CRT.

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