Publications by authors named "Xiaofu Zhuo"

Objective: To understand the infection of hepatitis B virus(HBV) in blood donors, and to evaluate the effectiveness and necessity of TMA technology for HBV-DNA screening in blood donors.

Methods: Using the ELISA/NAT model, routine serology test and NAT were performed in the 169 160 donors,including voluntary blood donors and some of donors returned to donor team. For some donors with test positive NAT, nucleic acid identification test was performed.

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Article Synopsis
  • The study investigated how repeated platelet donations (plateletpheresis) affect P-selectin levels in blood donors.
  • Results showed that platelet donors had higher soluble P-selectin (sP-selectin) levels compared to first-time whole blood donors, with frequent donations leading to consistently higher sP-selectin concentrations.
  • The findings suggest that increased sP-selectin levels may be linked to the frequency of donations, but further research is needed to understand the underlying mechanisms.
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Background: Recent genome-wide association studies in Caucasians suggested that an association exists between the ABO gene locus and soluble levels of P-selectin (sP-selectin). However, it is unclear if the relationship corresponds to the phenotypic expression of ABO groups or is present in different ethnic groups. The aim of this study was to verify this observation at both genotypic and phenotypic levels in a healthy Chinese population.

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To investigate the RHD gene profiles of RhD-negative individuals in population of Fujian Province, it was to design fourteen pairs of specific primers to amplify RHD exon 1, 3 approximately 7, 9, 10, hybrid Rh box, RHD 1227A allele, RHC allele, RHc allele, RHE allele and RHe allele. Rh genotypes were detected by PCR-SSP in 104 RhD-negative donors, some samples with or without RHD genes were analysed by the absorption-elution test, and two RhD-negative samples with eight RHD exons detected were analysed by DNA sequencing. The results showed that 61.

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