- The COVID-19 pandemic continues, with evolving SARS-CoV-2 variants showing mutations that enhance their infectivity and resistance to immunity, complicating control efforts.
- A new rapid genotyping method using recombinase polymerase amplification (RPA) and the nuclease Argonaute (Ago) detects key mutations like L452R with high sensitivity, able to identify as little as a single copy.
- The RPA-Ago method completes testing in about 1.5 hours with minimal lab requirements, making it suitable for local or on-site application, aiding precise epidemic control and treatment strategies for SARS-CoV-2 variants.