Transferrin receptor uptakes iron from tumor-associated neutrophils to regulate invasion patterns of OSCC.

Background: Transferrin receptor (TFRC) uptakes iron-loaded transferrin (TF) to acquire iron and regulates tumor development. Nonetheless, the clinical values and the precise functions of TF-TFRC axis in the development of oral squamous cell carcinoma (OSCC) were still undiscovered, especially the impacts of their regional heterogeneous expression.

Methods: Immunohistochemistry (IHC) was used to analyze the expression of TFRC in 106 OSCC patients.

Carbon sources derived from the invasive plant Spartina alterniflora improved the nitrogen removal in seawater constructed wetland.

Invasive alien plants pose a great threat to local plants and ecosystems. How to effectively alleviate this hazard is an unresolved issue. This study explored the carbon release characteristics of an invasive plant Spartina alterniflora and evaluated the ability of nitrogen removal from shrimp culture wastewater through constructing seawater wetland.

Molecularly tailorable metal oxide clusters ensured robust interfacial connection in inverted perovskite solar cells.

Interfacial recombination and ion migration between perovskite and electron-transporting materials have been the persisting challenges in further improving the efficiency and stability of perovskite solar cells (PVSCs). Here, we design a series of molecularly tailorable clusters as an interlayer that can simultaneously enhance the interaction with C and perovskite. These clusters have precisely controlled structures, decent charge carrier mobility, considerable solubility, suitable energy levels, and functional ligands, which can help passivate perovskite surface defects, form a uniform capping net to immobilize C, and build a robust coupling between perovskite and C.

[Heavy Metal Pollution Characteristics and Ecological Risk Assessment of Kafang Tin Tailings Pond].

To study the pollution characteristics and ecological risks of heavy metals in tailings ponds is an important prerequisite for protecting the surrounding environment and human health. The total amount and morphology of five "toxic" heavy metals （As, Cr, Cd, Pb, and Hg） in Kafang tin tailings pond were determined. Based on the aforementioned, we analyzed the distribution characteristics of heavy metals.

Exposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.

Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.

The Shh-p38-NFATc1 signaling pathway is essential for osteoclastogenesis during tooth eruption.

Tooth eruption, a critical stage in tooth development, is related to osteoclastogenesis. Intraperitoneal injection of Shh agonists into neonatal mice promoted tooth eruption at postnatal day (PN) 15, whereas treatment with the Shh inhibitor (LDE225) suppressed this process. When RAW264.

ITGB4/GNB5 axis promotes M2 macrophage reprogramming in NSCLC metastasis.

Objective: Metastasis of non-small cell lung cancer (NSCLC) is a leading cause of high mortality. In recent years, the role of M2 macrophages in promoting tumor metastasis within the tumor microenvironment has garnered increasing attention. This study aims to investigate the role and potential mechanisms of the ITGB4/GNB5 axis in regulating M2 macrophage reprogramming and influencing NSCLC metastasis.

Development and validation of a risk prediction model for postpartum urinary incontinence in primiparas with singleton pregnancies: a multicenter clinical investigation.

Background: Postpartum urinary incontinence (UI) is a serious condition that significantly affects the quality of life. Several studies have demonstrated that it is associated with pelvic floor dysfunction. This study aimed to develop and validate a UI risk prediction model to identify primiparas with singleton pregnancies at high risk.

Exploring optimal administration timing of pegylated recombinant human granulocyte colony-stimulating factor for chemotherapy-induced neutropenia in early breast cancer treated with pharmorubicin and endoxan: a prospective randomized controlled clinical trial.

Background: Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) is a treatment for preventing febrile neutropenia (FN) in patients with early breast cancer. However, the optimal injection timing of PEG-rhG-CSF after chemotherapy is obscure. The trial was designed to explore the best administration timing of PEG-rhG-CSF when breast cancer patients could benefit most.

Matching Pursuit Network: An Interpretable Sparse Time-Frequency Representation Method Toward Mechanical Fault Diagnosis.

Rotatory machinery commonly operates in complex environments with strong noise and variable working conditions. Time-frequency representation offers a valuable method for capturing and analyzing nonstationary characteristics, making it particularly suitable for identifying transient fault-related features. However, despite these advantages, extracting robust and interpretable fault features in machinery operating under variable speeds remains a challenge with existing techniques.

Platelet ultrastructural changes stored at room temperature versus cold storage observed by electron microscopy and structured illumination microscopy.

Our study seeks to provide a theoretical foundation for the clinical use of cold-stored platelets (CSPs) by interpreting ultrastructural images and quantitatively analyzing structural changes. CSPs, room temperature-stored platelets (RTPs), and delayed CSPs (delayed-CSPs) were continuously observed using scanning electron microscopy and transmission electron microscopy at eight time points. Super-resolution fluorescence microscopy was employed to observe changes in platelet microtubules and mitochondrial structure and function, whereas platelet counts, metabolism, and relevant functional indicators were measured concurrently.

Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality.

Study Question: Are reproductive factors associated with biological aging, and does biological aging mediate the associations of reproductive factors with premature mortality?

Summary Answer: Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects; PhenoAge-Accel mediated the associations between reproductive factors and premature mortality.

What Is Known Already: Accelerated aging is a key contributor to mortality, but knowledge about the effect of reproductive factors on aging is limited.

Study Design, Size, Duration: This prospective cohort study included 223 729 women aged 40-69 years from the UK biobank in 2006-2010 and followed up until 12 November 2021.

Application of Carbon Nanomaterials to Enhancing Tumor Immunotherapy: Current Advances and Prospects.

Recent advances in tumor immunotherapy have highlighted the pivotal role of carbon nanomaterials, such as carbon dots, graphene quantum dots, and carbon nanotubes. This review examines the unique benefits of these materials in cancer treatment, focusing on their mechanisms of action within immunotherapy. These include applications in immunoregulation, recognition, and enhancement.

Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome.

Iron oxide nanoparticles (IONPs) have wide applications in the biomedical field due to their outstanding physical and chemical properties. However, the potential adverse effects and related mechanisms of IONPs in human organs, especially the lung, are still largely ignored. In this study, we found that group-modified IONPs (carboxylated, aminated and silica coated) induce slight lung cell damage (in terms of the cell cycle, reactive oxygen species (ROS) production, cell membrane integrity and DNA damage) at a sublethal dosage.

Efficient mineralization of cadmium and arsenic by poorly crystalline CaFe-layered double hydroxide in soil: Performance and mechanism.

The co-contamination of arsenic (As) and cadmium (Cd) in the environment is of most concern. In this work, poorly crystalline CaFe-layered double hydroxide (CaFe-LDH) was synthesized with a Ca-to-Fe molar ratio of 4 to ensure effective immobilization of Cd and As in soil. The application of CaFe-LDH in soil remediation demonstrated that the targeted heavy metals gradually mineralized into a relatively stable oxidizable and residual state.

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts.

Desmoplasia in fibroblasts within metastatic lymph nodes (MLNs) serves as an indicator of extranodal extension (ENE), which led mortality in oral squamous cell carcinoma (OSCC). However, systematic studies on fibroblasts in MLNs are lacking. Therefore, this study characterized the differences in phenotype, function, and origin of fibroblasts between primary tumors (PTs) and lymph nodes (LNs) in OSCC.

Unified ionic and radical C-4 alkylation and arylation of pyridines.

C-H Functionalization of pyridines is an efficient strategy to access pyridine derivatives occurring in pharmaceuticals, agrochemicals, and materials. Nucleophilic additions to pyridiniums both ionic and radical species have proven particularly useful. However, these reactions suffer from poor regioselectivity.

The influence of eight cognitive training regimes upon cognitive screening tool performance in post-stroke survivors: a network meta-analysis.

Background: Traditional meta-analysis offers only direct comparative evidence. The optimal cognitive training for poststroke cognitive impairment (PSCI) remains largely undetermined.

Objectives: This study aims to assess and compare the effectiveness of selected cognitive training methods for PSCI patients and to identify and rank the most effective intervention programs.

Maxillary impacted canine replacing a central incisor with root resorption: Multidisciplinary treatment in a preadolescent patient.

Maxillary canines are often impacted, which can result in tooth disorders and adversely affect occlusal and facial development. The case report describes complete bilateral impaction of maxillary canines and significant root resorption of a central incisor. The multidisciplinary approach is the optimal strategy for addressing impacted maxillary canines.