Publications by authors named "Xiaofeng Cang"
Article Synopsis
- Rheumatoid arthritis-related interstitial lung disease (RA-ILD) is a common complication in rheumatoid arthritis patients that negatively impacts their quality of life, and the study focuses on understanding immune cell infiltration and Sonic Hedgehog (Shh) signaling in this condition.
- The CIBERSORT algorithm was used to analyze the presence of 22 types of immune cells in RA-ILD lung tissues, revealing that certain target genes are linked to immune regulation and pathways involved in the disease.
- The results indicated lower expression levels of Shh, Smoothened (Smo), and BMP proteins in RA-ILD patients compared to controls, highlighting significant immune cell infiltration in the lung tissues of those affected by RA-ILD.
Circular RNAs (circRNAs) are involved in the progression of various diseases, including lupus nephritis. Hsa_circ_0010957 is reported to be dysregulated in lupus nephritis, but the exact function of this circRNA is unknown. This research aims to study the function and mechanism of circRNA hsa_circ_0010957 in a lipopolysaccharide (LPS)-induced cellular model of lupus nephritis.
View Article and Find Full Text PDFObjectives: Mesenchymal stem cells (MSCs) have shown an obvious protective effect on acute pancreatitis (AP). The purpose of the present study was to analyze the effect of bone marrow MSC-derived microvesicles (bmMSC-MVs) on AP and explore the underlying mechanisms.
Methods: Bone marrow MSCs and bmMSC-MVs were isolated from Sprague-Dawley rats.
Rosmarinic Acid (RA), a caffeic acid ester, has been shown to exert anti-inflammation, anti-oxidant and antiallergic effects. Our study aimed to investigate the effect of RA in sodium taurocholate ( NaTC )-induced acute pancreatitis, both in vivo and in vitro. In vivo, RA (50 mg/kg) was administered intraperitoneally 2 h before sodium taurocholate injection.
View Article and Find Full Text PDFObjectives: The goal of this study was to summarize the clinical features of hyperlipidemic acute pancreatitis (HLAP), and help clinicians understand the characteristic presentations of HLAP.
Methods: From July 2009 to June 2013, 1073 cases of acute pancreatitis were retrospectively assessed. The clinical characteristics of HLAP and non-HLAP were statistically analyzed.
Objectives: Mesenchymal stem cells (MSCs) have shown an obvious protective effect on systemic inflammation. The purpose of this study is to assess the effect and possible mechanism of bone marrow MSCs (bmMSCs) on acute pancreatitis (AP).
Methods: BmMSCs of SD rats were isolated and cultured in vitro.
Objectives: The goal of this study is to evaluate the role of C-reactive protein (CRP) in predicting the severity of hyperlipidemic acute pancreatitis (HLAP) compared with non-HLAP (NHLAP).
Methods: A total of 1073 episodes of acute pancreatitis between July 2009 and June 2013 were retrospectively studied. The clinical characteristics and laboratory data of HLAP and NHLAP were statistically analyzed on days 1, 2, 3, 4, and 6, especially the CRP level.
Diosmetin (3', 5, 7-trihydroxy-4'-methoxyflavone), the aglycone part of the flavonoid glycosides diosmin occurs naturally in citrus fruit, was considered to exhibit anti-inflammatory and antioxidant properties. Our study aimed to investigate the effect of diosmetin in a murine model of cerulein-induced acute pancreatitis (AP). Experimental AP was induced in mice by seven intraperitoneal injection of cerulein (50 ug/kg) at hourly intervals.
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