CNS Neurosci Ther
December 2024
Introduction: This review delves into the intricate relationship between NLR inflammasomes, particularly the NLRP3 inflammasome, and the immune-mediated neurodegenerative disease, multiple sclerosis (MS). While the precise etiology of MS remains elusive, compelling research underscores the pivotal role of the immune response in disease progression. Notably, recent investigations highlight the significant involvement of NLRP3 inflammasomes in various autoimmune diseases, prompting an in-depth exploration of their impact on MS.
View Article and Find Full Text PDFForage-grain ratoon rice (FG-RR) systems, integrating grain and forage production, promise a sustainable approach to enhance food security and livestock development in marginal regions where ratoon rice (T-RR) is traditionally cultivated. Here, we quantified zinc (Zn), copper (Cu), arsenic (As), and cadmium (Cd) concentrations in ratoon crop grains from 23 rice varieties at four mowing stages (heading, milk-ripening, dry-ripening, and full maturity) of the main crop. Early mowing at the milk-ripening stage significantly reduced As levels (16.
View Article and Find Full Text PDFMechanical computing promises to integrate semiconductor-based digital logic in several applications, but it needs straightforward programmable devices for changing computing rules in situ. A methodology based on strain-governed, bistable soft shells that process digital information by interchanging their internal/external surfaces is proposed. This bistable behavior, explained via model-based design, safeguards robustness by working only once for each input pulse.
View Article and Find Full Text PDFMacrofungi do not exist in isolation but establish symbiotic relationships with microorganisms, particularly bacteria, within their fruiting bodies. Herein, we examined the fruiting bodies' bacteriome of seven species of the genus collected from four locations in Yunnan, China. By analyzing bacterial diversity, community structure, and function through 16S rRNA sequencing, we observed the following: (1) In total, 4,840,291 high-quality bacterial sequences obtained from the fruiting bodies were grouped into 16,577 amplicon sequence variants (ASVs), and all samples comprised 23 shared bacterial ASVs.
View Article and Find Full Text PDFRheumatol Immunol Res
September 2024
Based on a multi-locus phylogeny of a combined dataset of ITS, LSU, α, and and comprehensive morphological analyses, we describe three new species from the Melanosporum group of genus and synonymize and . Phylogenetically, the three newly described species, , and , differ significantly in genetic distance from any previously known species. Morphologically, is distinctly different from its closest phylogenetically related species, , due to its long shuttle-shape spores (average the ratio of spore length to spore width for all spores (Qm) = 1.
View Article and Find Full Text PDFDiscinaceae holds significant importance within the Pezizales, representing a prominent group of macroascomycetes distributed globally. However, there is a dearth of genomic studies focusing on this family, resulting in gaps in our understanding of its evolution, development, and ecology. Here we utilized state-of-the-art genome assembly methodologies, incorporating third-generation single-molecule fluorescence and Hi-C-assisted methods, to elucidate the genomic landscapes of Gyromitra esculenta and Paragyromitra xinjiangensis.
View Article and Find Full Text PDFCo-composting with exogenous microbial inoculant, presents an effective approach for the harmless utilization of livestock manure and agroforestry wastes. However, the impact of inoculant application on the variations of viral and antibiotic resistance genes (ARGs) remains poorly understood, particularly under varying manure quantity (low 10 % vs. high 20 % w/w).
View Article and Find Full Text PDFObjective: To investigate the effect of AngioJet thrombectomy combined with catheter-contact thrombolysis on the therapeutic effect and safety of patients with lower extremity deep vein thrombosis (LEDVT).
Methods: 48 patients with LEDVT admitted to our hospital from February 2020 to January 2022 were selected as the study objects and were divided into a control group (n = 24) and research group (n = 24) by random number table method. The control group was treated with catheter-directed thrombolysis (CDT) while the research group was treated with a combination of CDT and AngioJet thrombectomy.
Background: FOXP3 is a transcription factor that regulates the development and function of Treg, playing an essential role in preventing autoimmune diseases. Variation in can impair the function of Treg cells, thus destroying their inhibitory capacity and leading to autoimmune diseases. This paper investigated whether the three SNPs in the gene (-3279 C/A, -924 A/G and -6054 del/ATT) are associated with systemic lupus erythematosus (SLE) susceptibility in the Han Chinese population.
View Article and Find Full Text PDFMicrobial inoculation plays a significant role in promoting the efficiency of biowaste conversion. This study investigates the function of Streptomyces-Bacillus Inoculants (SBI) on carbon (C) and nitrogen (N) conversion, and microbial dynamics, during cow manure (10% and 20% addition) and corn straw co-composting. Compared to inoculant-free controls, inoculant application accelerated the compost's thermophilic stage (8 vs 15 days), and significantly increased compost total N contents (+47%) and N-reductase activities (nitrate reductase: +60%; nitrite reductase: +219%).
View Article and Find Full Text PDFThe water reuse facilities of industrial parks face the challenge of managing a growing variety of wastewater sources as their inlet water. Typically, this clustering outcome is designed by engineers with extensive expertise. This paper presents an innovative application of unsupervised learning methods to classify inlet water in Chinese water reuse stations, aiming to reduce reliance on engineer experience.
View Article and Find Full Text PDFObjective: The early targeted and effective diagnosis and treatment of severe trauma are crucial for patients' outcomes. Blood leukocytes act as significant effectors during the initial inflammation and activation of innate immunity in trauma. This study aims to identify hub genes related to patients' prognosis in blood leukocytes at the early stages of trauma.
View Article and Find Full Text PDFSimultaneously achieving economic development and environmental protection is a shared global challenge. While the positive effect of environmental regulations on protecting the environment has been widely recognized, the attention paid to low-carbon governance and corporate green transformation remains insufficient. Based on the two-stage least square regression model (2SLS) of instrumental variables, this paper utilizes panel data from China to identify the influence mechanism of government low-carbon governance on enterprise green development.
View Article and Find Full Text PDFBest Pract Res Clin Rheumatol
May 2024
B cells are central players in the immune system, responsible for producing antibodies and modulating immune responses. This review explores the intricate relationship between aberrant B cell activation and the development of autoimmune diseases, emphasizing the essential role of B cells in these conditions. We also summarize B cell receptor signaling and Toll-like receptor signaling in B cell activation, as well as their association with autoimmune diseases, shedding light on the molecular mechanisms behind these associations.
View Article and Find Full Text PDFspp. are potentially important economic fungi within Morchellaceae. However, fundamental research on their mating systems, the key aspects of their life cycle, remains scarce.
View Article and Find Full Text PDFTrue morels (, Pezizales) are a popular edible and medicinal fungus with great nutritional and economic value. The dynamics and regulatory mechanisms during the morphogenesis and maturation of morels are poorly understood. In this study, the metabolomes and transcriptomes of the mycelium (MY), primordium differentiation (PR), young fruiting body (YFB), and mature fruiting body (MFB) were comprehensively analyzed to reveal the mechanism of the morphogenesis and maturation of .
View Article and Find Full Text PDFPediatr Rheumatol Online J
October 2023
Objective: Synovial fibroblasts in patients with rheumatoid arthritis (RA) contribute substantially to the perpetuation of synovitis and invasion to cartilage and bone, and are potential therapeutic targets. Fibroblast activation protein (FAP) is highly expressed by RA synovial fibroblasts and the expression is relatively specific. We tested whether FAP can serve as a molecular target to modulate synovial fibroblasts for therapy in experimental arthritis.
View Article and Find Full Text PDFZhongguo Yi Liao Qi Xie Za Zhi
September 2023
The establishment of mental health assessment system provides a new way for the early diagnosis of mental health problems, in view of the growing population of mental diseases and problems and the uneven distribution of mental health resources. In the mental health assessment system, intelligent assistant diagnosis can assist or help psychiatrists improve their work efficiency. Intelligent assistant diagnosis provides technical support for predictive screening and auxiliary diagnosis of mental health problems.
View Article and Find Full Text PDFMultiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Sinomenine (SIN), a bioactive alkaloid extracted from the Chinese medicinal plant Sinomenium acutum, has powerful anti-inflammatory and immunosuppressive therapeutic benefits. In our previous research, we found that SIN increased resistance to oxidative stress via the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in PC12 neuronal cells.
View Article and Find Full Text PDFMorels are one of the most highly prized edible and medicinal mushrooms worldwide. Therefore, historically, there has been a large international interest in their cultivation. Numerous ecological, physiological, genetic, taxonomic, and mycochemical studies have been previously developed.
View Article and Find Full Text PDFInformation disclosure is an important way for investors to obtain information, the annual report text carries a lot of information, lazy information disclosure is an important form of information disclosure of the annual report text. This paper takes China's A-share listed companies from 2011 to 2022 as the research sample, takes the annual report text information disclosure form as the entry point, uses the computer text analysis technology to measure the text similarity of the annual report to measure the lazy information disclosure, and explores its impact on stock price crash risk. The results show that there is a positive correlation between the similarity of annual report text and the risk of stock price crash, that is, when the information of annual report text is presented in the form of lazy information disclosure, the risk of stock price crash increases.
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