Publications by authors named "Xiaodong Long"
Background: Exosomes derived from primary chondrogenic stem/progenitor cells (CSPCs-EXOs) show promise in cartilage repair due to their immunomodulatory and regenerative properties. However, their specific therapeutic potential in osteoarthritis (OA), especially in modulating immune responses and enhancing chondrocyte function, requires further exploration. This study aims to clarify CSPCs-EXOs' effects on OA by investigating their role in chondrocyte proliferation, migration, inflammation inhibition, and cartilage regeneration.
View Article and Find Full Text PDFBackground And Purpose: The systemic immune-inflammation index (SII) is a novel immune inflammatory marker which has been proven to have excellent predictive value for many diseases. The aim of this study was to investigate the predictive value of SII at different time points after admission for functional outcome at discharge in patients with intracerebral hemorrhage (ICH).
Methods: The clinical data of patients with ICH who were treated at a medical center for neurological diseases in China between October 2012 and April 2022 were analyzed in this retrospective study.
Article Synopsis
- - A new multi-layer stacked Dynamic Random Access Memory (DRAM) platform is developed to tackle the memory wall issue, featuring high-density vertical connections between DRAM and logic units using advanced bonding and TSV technologies.
- - The paper introduces a Cross-Process Signal Integrity Analysis (CPSIA) method that combines different manufacturing processes to analyze the signal integrity of a 3D integrated circuit (3DIC) architecture, modeling vertical cells and connecting DRAM and logic netlists in one simulation.
- - Simulation results indicate that timing uncertainty due to 3DIC crosstalk ranges from 31 ps to 62 ps, correlating with variations in maximum frequency observed in physical tests, thus validating the CPSIA method's
Microplastics (MPs), a pervasive pollutant in aquatic environments, are increasingly recognized for their detrimental effects on aquatic organisms. However, the present understanding of their impact on phytoplankton, particularly freshwater microalgae, remains limited. Furthermore, previous studies have predominantly focused on MP particles, largely overlooking the most prevalent form of MPs in aquatic settings-fibers.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the safety and effectiveness of combining microvascular reconstruction with decompressive craniectomy (DHC) in patients under 60 with malignant middle cerebral artery infarctions (MMCA).
- A total of 6 patients received immediate vascular revascularization, while 12 received only DHC, allowing for a comparison of outcomes.
- Results showed that after 3 months, those who had the combined treatment had significantly better neurological recovery, suggesting that this approach could be a viable option for improving patient outcomes.
Bisphenol A has a sex-dependent disruptive effect on hepatic lipid metabolism in zebrafish.
Comp Biochem Physiol C Toxicol Pharmacol
June 2023
Bisphenol A (BPA) is an endocrine disruptor that has adverse effects on lipid metabolism. However, most of the current studies on the effects of BPA on lipid metabolism in fish have focused on middle- and short-term exposure tests. The aim of this study was to investigate the effects of long-term BPA exposure on liver lipid metabolism in zebrafish.
View Article and Find Full Text PDFBackground: It remains unknown if ultra-early (within 24 hours after onset) treatment can improve the prognosis in patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH). We aimed to evaluate the effect of ultra-early treatment on functional outcomes and mortality in patients with poor-grade aSAH via a systematic review and meta-analysis.
Methods: We performed a literature search in the PubMed, MEDLINE, and Web of Science databases.
In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats.
View Article and Find Full Text PDFThis study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury, and correlate these changes to the formation of brain edema. Results revealed that at 2 hours after cerebral contusion and laceration injury, aquaporin 4 expression significantly increased, brain water content and blood-brain barrier permeability increased, and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased. In addition, the mitochondrial accumulation was observed.
View Article and Find Full Text PDFObjective: To investigate the impact of all-trans retinoic acid (ATRA) on MDM2 gene expression in astrocytoma cell line SHG-44, and to provide basic data for further research on the progression mechanism and gene therapy of human astrocytoma.
Methods: The differential expressions of MDM2 gene and protein in SHG-44 cells were detected by cDNA microarray and Western blot, respectively, before and after treatment of ATRA. The expressions of MDM2 protein in WHO grade II and grade IV astrocytomas were determined by immunohistochemical streptavidin-peroxidase method.