The design of nanomaterials enclosed by high-index facets plays a critical role in the surface-sensitive properties. Herein, hierarchical CuCoO microflowers (CCO-F) with highly exposed high-index (112) facets are rationally designed via a solvothermal method followed by calcination. CCO-F are composed of 30 nm-thick nanoflakes and have an ultrahigh specific surface area of .
View Article and Find Full Text PDFGlucose detection is essential in clinical medicine, and the reasonable design of metal oxide electrocatalysts plays a crucial role in developing efficient nonenzymatic glucose (NEG) sensors. Herein, grain boundary/doping/architecture engineering is used to tailor the structures of CuO nanomaterials and tune their surface/electron-transfer properties toward enhanced electrocatalytic oxidation of glucose. Hierarchical N-doped CuO microflowers (N-CuO-MF) are synthesized using a facile hydrothermal method, followed by calcination.
View Article and Find Full Text PDFEsophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy known for its aggressive nature and unfavorable outcomes. Identifying new biomarkers is crucial for the early detection and improved prognostication of ESCC. The circadian clock and NIMA-related kinase 2 (NEK2) are pivotal in cancer development.
View Article and Find Full Text PDFProcessing lignin into nanoparticles (LNPs) offers a promising utilization strategy; however, its structural and molecular weight heterogeneity poses challenges in the formation of uniform LNPs. In this study, industrial kraft lignin was fractionated in stepwise molecular weight (Mw) from low to high and from which LNPs were fabricated via antisolvent precipitation. The results showed that lignin with high Mw benefits the formation of uniform and smaller-sized LNPs.
View Article and Find Full Text PDFRibophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, functions as a conserved ribophagy receptor in multiple organisms.
View Article and Find Full Text PDFWadsley-Roth phase TiNbO has been known as a potential anode material in high-power lithium-ion batteries (LIBs) owing to its enhanced safety, reliable cycling performance, and substantial theoretical capacity. However, its commercial application is restricted by poor electronic conductivity and slow Li-ion migration kinetics. Herein, we have developed urchin-structured TiNbO microspheres with an ultrathin N-doped carbon coating through a two-step hydrothermal and polydopamine carbonization process.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Zeolite-based hemostats are commercially available but are still troubled by the adverse effects of exothermic heat-caused tissue damage and detached zeolite-induced distal thrombosis. Here, we developed a facile and robust method to fabricate zeolite-embedded regenerated cellulose aerogel (Z-RCA) for safe and efficient hemostasis. Zeolite particles were extensively entangled by regenerated cellulose nanofibers via hydrogen bonds during the cellulose regeneration process, thus reducing the probability of zeolite detaching from aerogel.
View Article and Find Full Text PDFThe activation of immune-stimulatory molecules is critical for effective antitumor immunotherapy. Mechanical high-intensity focused ultrasound (mHIFU) sustains this activation in tumor cell debris through cavitation. To enhance cavitation, perfluorohexane nanodroplets (NDs-PFH) were utilized in this study to lower the cavitation threshold during mHIFU ablation.
View Article and Find Full Text PDFDecentralized testing using multiplex lateral flow assays (mLFAs) to simultaneously detect multiple analytes can significantly enhance detection efficiency, reduce cost and time, and improve analytic accuracy. However, the challenges, including the monochromatic color of probe particles, interference between different test lines, and reduced specificity and sensitivity, severely hinder mLFAs from wide use. In this study, we prepared polydopamine (PDA)-coated dyed cellulose nanoparticles (dCNPs@P) with tunable colors as the probe for mLFAs.
View Article and Find Full Text PDFObjective: After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities ('caps/tracks') to the index infarct on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated the clinicoradiological correlates of 'caps/tracks', and their impact on long-term outcomes following RSSI.
View Article and Find Full Text PDFChemotherapy is important in the systemic therapy for breast cancer. However, after chemotherapy, the left living tumour cells are more progressive. There is an urgent need to study the underlying mechanism which is still unclear to further improve the therapeutic efficacy of chemotherapy in breast cancer.
View Article and Find Full Text PDFLow-density lipoprotein (LDL) plays a crucial role in the development of cardiovascular disease. Lowering the level of LDL is an effective therapeutic strategy for treating cardiovascular disease. Here, we developed a facile and robust method to prepare carboxymethyl cellulose beads (CMCBs) for selectively adsorbing LDL.
View Article and Find Full Text PDFThe inoculants of arbuscular mycorrhizal fungi (AMF) propagated by the culture system is important in scientific research; however, the long-term storage reduces the spore germination rate. The propagules of AMF consist of three components, including spores, hyphae and colonized root fragments. It is well known that cold storage can improve the germination rate of AMF spores, with limited investigations on the germination of other propagules.
View Article and Find Full Text PDFOptical coherence tomography angiography (OCT-A) retinal imaging enables visualization of the retinal microvasculature that is developmentally related to the brain and can offer insight on cerebrovascular health. We investigated retinal phenotypes and neuroimaging markers of small vessel disease (SVD) in individuals with obstructive sleep apnoea (OSA). We enrolled 44 participants (mean age 50.
View Article and Find Full Text PDFDrought stress poses increasingly serious threats to agricultural production in the era of global climate change. Arbuscular mycorrhizal (AM) fungi are well-recognized biostimulants promoting plant tolerance to drought stress. Lipids are indispensable for AM fungal colonization, however, the involvement of lipid metabolism in the drought tolerance conferred by AM fungi is largely unknown.
View Article and Find Full Text PDFIdentifying and preventing patients who are not likely to benefit long-term from total knee arthroplasty (TKA) would decrease healthcare expenditure significantly. We trained machine learning (ML) models (image-only, clinical-data only, and multimodal) among 5720 knee OA patients to predict postoperative dissatisfaction at 2 years. Dissatisfaction was defined as not achieving a minimal clinically important difference in postoperative Knee Society knee and function scores (KSS), Short Form-36 Health Survey [SF-36, divided into a physical component score (PCS) and mental component score (MCS)], and Oxford Knee Score (OKS).
View Article and Find Full Text PDFThe utilization of MnO anodes with high storage capacity is significantly hindered by rapid capacity fading and inadequate rate capability, stemming from substantial volume fluctuations and low electrical conductivity. Crafting a composite comprising sulfur and fluorine co-modified MnO nanoparticles integrated with sulfur and nitrogen co-doped carbon matrices promises enhanced electrochemical performance yet poses formidable obstacles. Here, we present a straightforward synthetic strategy for in situ growth of sulfur and fluorine co-modified MnO nanoparticles onto sulfur and nitrogen co-doped carbon scaffolds.
View Article and Find Full Text PDFIntroduction: Sleep disturbances including obstructive sleep apnea (OSA) and poor sleep quality are common after stroke, while its association with cognitive changes following transient ischemic attack (TIA) or mild stroke remains unclear. We aim to determine whether sleep duration, OSA parameters, or nocturnal hypoxemia is associated with a greater cognitive decline after stroke.
Methods: We prospectively followed-up patients with acute TIA/mild stroke [National Institute Health Stroke Scale (NIHSS) < 7] who underwent baseline sleep questionnaire [Pittsburgh Sleep Quality Index (PSQI)], and serial cognitive assessments [Montreal Cognitive Assessment (MoCA) 5-min, Stroop Test] at baseline and one-year.
Polymers (Basel)
September 2024
Bacterial cellulose (BC) is a broadly utilized natural nanofiber produced by microbial fermentation, but its high-cost and low-yield production and limited function still hinder its application. Here, we used the spraying-assisted biosynthesis method to introduce biomass nanofibers along with the nutrient media to the fermenting BC. Biomass nanofibers could be cellulose, chitosan, and others.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2024
Reducing unnecessary blood loss in hemostasis is a major challenge for traditional hemostatic materials due to uncontrolled blood absorption. Tuning the hydrophilic and hydrophobic properties of hemostatic materials provides a road to reduce blood loss. Here, we developed a superhydrophobic aerogel that enabled remarkably reduced blood loss.
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