Publications by authors named "Xiaodi Liu"

The design of nanomaterials enclosed by high-index facets plays a critical role in the surface-sensitive properties. Herein, hierarchical CuCoO microflowers (CCO-F) with highly exposed high-index (112) facets are rationally designed via a solvothermal method followed by calcination. CCO-F are composed of 30 nm-thick nanoflakes and have an ultrahigh specific surface area of .

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Glucose detection is essential in clinical medicine, and the reasonable design of metal oxide electrocatalysts plays a crucial role in developing efficient nonenzymatic glucose (NEG) sensors. Herein, grain boundary/doping/architecture engineering is used to tailor the structures of CuO nanomaterials and tune their surface/electron-transfer properties toward enhanced electrocatalytic oxidation of glucose. Hierarchical N-doped CuO microflowers (N-CuO-MF) are synthesized using a facile hydrothermal method, followed by calcination.

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Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy known for its aggressive nature and unfavorable outcomes. Identifying new biomarkers is crucial for the early detection and improved prognostication of ESCC. The circadian clock and NIMA-related kinase 2 (NEK2) are pivotal in cancer development.

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Processing lignin into nanoparticles (LNPs) offers a promising utilization strategy; however, its structural and molecular weight heterogeneity poses challenges in the formation of uniform LNPs. In this study, industrial kraft lignin was fractionated in stepwise molecular weight (Mw) from low to high and from which LNPs were fabricated via antisolvent precipitation. The results showed that lignin with high Mw benefits the formation of uniform and smaller-sized LNPs.

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Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mammalian receptor for ribophagy, its homologues do not exist in yeast and nematodes. Here we demonstrate that Rpl12, a ribosomal large subunit protein, functions as a conserved ribophagy receptor in multiple organisms.

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Wadsley-Roth phase TiNbO has been known as a potential anode material in high-power lithium-ion batteries (LIBs) owing to its enhanced safety, reliable cycling performance, and substantial theoretical capacity. However, its commercial application is restricted by poor electronic conductivity and slow Li-ion migration kinetics. Herein, we have developed urchin-structured TiNbO microspheres with an ultrathin N-doped carbon coating through a two-step hydrothermal and polydopamine carbonization process.

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Zeolite-based hemostats are commercially available but are still troubled by the adverse effects of exothermic heat-caused tissue damage and detached zeolite-induced distal thrombosis. Here, we developed a facile and robust method to fabricate zeolite-embedded regenerated cellulose aerogel (Z-RCA) for safe and efficient hemostasis. Zeolite particles were extensively entangled by regenerated cellulose nanofibers via hydrogen bonds during the cellulose regeneration process, thus reducing the probability of zeolite detaching from aerogel.

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The activation of immune-stimulatory molecules is critical for effective antitumor immunotherapy. Mechanical high-intensity focused ultrasound (mHIFU) sustains this activation in tumor cell debris through cavitation. To enhance cavitation, perfluorohexane nanodroplets (NDs-PFH) were utilized in this study to lower the cavitation threshold during mHIFU ablation.

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Decentralized testing using multiplex lateral flow assays (mLFAs) to simultaneously detect multiple analytes can significantly enhance detection efficiency, reduce cost and time, and improve analytic accuracy. However, the challenges, including the monochromatic color of probe particles, interference between different test lines, and reduced specificity and sensitivity, severely hinder mLFAs from wide use. In this study, we prepared polydopamine (PDA)-coated dyed cellulose nanoparticles (dCNPs@P) with tunable colors as the probe for mLFAs.

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Objective: After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities ('caps/tracks') to the index infarct on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigated the clinicoradiological correlates of 'caps/tracks', and their impact on long-term outcomes following RSSI.

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Chemotherapy is important in the systemic therapy for breast cancer. However, after chemotherapy, the left living tumour cells are more progressive. There is an urgent need to study the underlying mechanism which is still unclear to further improve the therapeutic efficacy of chemotherapy in breast cancer.

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Low-density lipoprotein (LDL) plays a crucial role in the development of cardiovascular disease. Lowering the level of LDL is an effective therapeutic strategy for treating cardiovascular disease. Here, we developed a facile and robust method to prepare carboxymethyl cellulose beads (CMCBs) for selectively adsorbing LDL.

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The inoculants of arbuscular mycorrhizal fungi (AMF) propagated by the culture system is important in scientific research; however, the long-term storage reduces the spore germination rate. The propagules of AMF consist of three components, including spores, hyphae and colonized root fragments. It is well known that cold storage can improve the germination rate of AMF spores, with limited investigations on the germination of other propagules.

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Optical coherence tomography angiography (OCT-A) retinal imaging enables visualization of the retinal microvasculature that is developmentally related to the brain and can offer insight on cerebrovascular health. We investigated retinal phenotypes and neuroimaging markers of small vessel disease (SVD) in individuals with obstructive sleep apnoea (OSA). We enrolled 44 participants (mean age 50.

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Article Synopsis
  • Ultrahigh-strength and lightweight materials are typically challenging to create due to the relationship between mechanical properties and density.
  • The study introduced a new method combining freeze casting and solvent exchange to produce cellulose nanofiber foams that are both lightweight and ultra-strong, featuring a unique 3D network structure.
  • The resulting foams exhibited impressive mechanical properties, with maximum compressive and bending moduli of 26.09 and 42.10 MPa, respectively, along with a low density of 210.16 mg/cm³, demonstrating a promising approach for future material applications.
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Article Synopsis
  • A significant portion of ischemic strokes are classified as lacunar subtypes, often characterized by recent small subcortical infarcts (RSSIs), but the long-term effects of these conditions are not well understood.
  • In a study involving 108 participants, hemosiderin deposits (HDs) were found in over half of them within 3 months, and in about 77% within 12 months, with a notable "rim" pattern suggesting they could resemble primary hemorrhage.
  • The study highlighted that the volume of the infarct and a higher total small vessel disease (SVD) score are predictive of the presence of HDs, emphasizing the importance of not misinterpreting these deposits as signs of bleeding in chronic
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Drought stress poses increasingly serious threats to agricultural production in the era of global climate change. Arbuscular mycorrhizal (AM) fungi are well-recognized biostimulants promoting plant tolerance to drought stress. Lipids are indispensable for AM fungal colonization, however, the involvement of lipid metabolism in the drought tolerance conferred by AM fungi is largely unknown.

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Identifying and preventing patients who are not likely to benefit long-term from total knee arthroplasty (TKA) would decrease healthcare expenditure significantly. We trained machine learning (ML) models (image-only, clinical-data only, and multimodal) among 5720 knee OA patients to predict postoperative dissatisfaction at 2 years. Dissatisfaction was defined as not achieving a minimal clinically important difference in postoperative Knee Society knee and function scores (KSS), Short Form-36 Health Survey [SF-36, divided into a physical component score (PCS) and mental component score (MCS)], and Oxford Knee Score (OKS).

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The utilization of MnO anodes with high storage capacity is significantly hindered by rapid capacity fading and inadequate rate capability, stemming from substantial volume fluctuations and low electrical conductivity. Crafting a composite comprising sulfur and fluorine co-modified MnO nanoparticles integrated with sulfur and nitrogen co-doped carbon matrices promises enhanced electrochemical performance yet poses formidable obstacles. Here, we present a straightforward synthetic strategy for in situ growth of sulfur and fluorine co-modified MnO nanoparticles onto sulfur and nitrogen co-doped carbon scaffolds.

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Introduction: Sleep disturbances including obstructive sleep apnea (OSA) and poor sleep quality are common after stroke, while its association with cognitive changes following transient ischemic attack (TIA) or mild stroke remains unclear. We aim to determine whether sleep duration, OSA parameters, or nocturnal hypoxemia is associated with a greater cognitive decline after stroke.

Methods: We prospectively followed-up patients with acute TIA/mild stroke [National Institute Health Stroke Scale (NIHSS) < 7] who underwent baseline sleep questionnaire [Pittsburgh Sleep Quality Index (PSQI)], and serial cognitive assessments [Montreal Cognitive Assessment (MoCA) 5-min, Stroop Test] at baseline and one-year.

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Bacterial cellulose (BC) is a broadly utilized natural nanofiber produced by microbial fermentation, but its high-cost and low-yield production and limited function still hinder its application. Here, we used the spraying-assisted biosynthesis method to introduce biomass nanofibers along with the nutrient media to the fermenting BC. Biomass nanofibers could be cellulose, chitosan, and others.

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Reducing unnecessary blood loss in hemostasis is a major challenge for traditional hemostatic materials due to uncontrolled blood absorption. Tuning the hydrophilic and hydrophobic properties of hemostatic materials provides a road to reduce blood loss. Here, we developed a superhydrophobic aerogel that enabled remarkably reduced blood loss.

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Article Synopsis
  • - The study aimed to investigate how often new brain infarcts occur within a year after a minor stroke and their connections to existing cerebral small vessel disease (SVD), vascular risk factors, and cognitive decline.
  • - Researchers followed 229 stroke patients over a year, using MRI scans to find 117 new infarcts in 24.8% of participants, primarily in small subcortical areas rather than cortical areas.
  • - The baseline SVD score was found to be the strongest predictor of new infarcts, while cognitive tests at one year showed lower scores correlated with previous cognitive performance and intelligence, indicating a potential decline in cognitive function related to these infarcts.
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