Investigation of self-regulation mechanisms of extracellular organic matters in reused medium on Spirulina platensis.

Recirculating the cultivation medium of Spirulina platensis (S. platensis) enables efficient water and nutrient recycling, thereby reducing production costs. To figure out the inhibition components of the reused medium and cell oxidate response, this study delves into the metabolic regulation of the reused medium and its extracted organic matters (OMs) and extracellular polysaccharides (EPS) on S.

Bioinspired Durable Daytime Radiative Cooling Wood: Realizing Outdoor Longtime Use.

Daytime radiative cooling dissipates heat from surfaces by reflecting sunlight and emitting infrared radiation to outer space, featuring zero-energy consumption. Wood-based coolers have received more attention due to their high infrared emissivity, sustainability, and low cost. However, they often degrade under ultraviolet (UV) radiation exposure, resulting in a poor cooling efficiency.

WO@Ferrocene-Folic Acid Composites Induce Cancer Cell Death and Activate Immunity via PTT/CDT.

At present, tumor immune escape is a major problem in the treatment of tumors. The complex network of tumor microenvironments significantly impairs the efficacy of immunotherapy. This paper reports the preparation and immunoantitumor activity of a novel multifunctional defect tungsten trioxide@ferrocene-folic acid composite (WO@Fe-FA) with a high Fenton reaction rate.

pH-Responsive Engineered Exosomes Enhance Endogenous Hyaluronan Production by Reprogramming Chondrocytes for Cartilage Repair.

Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has a short duration in vivo and requires multiple injections. Here, a new strategy for in situ reprogramming chondrocytes to continuously produce endogenous high molecular weight HA is developed.

Mining TCGA to reveal immunotherapy-related genes for soft tissue sarcoma.

Immunotherapy of soft tissue sarcoma is considered an important development direction for the future. Bioinformatics analysis of genetic changes in tumors and the immune microenvironment around tumors has proven to be a mature and reliable method for predicting tumor prognosis. By mining the Cancer Genome Atlas Program database, we found immunotherapy targets of soft tissue sarcoma and analyzed their biological behavior.

Global prevalence of internet addiction among university students: a systematic review and meta-analysis.

Purpose Of Review: The prevalence of internet addiction among university students has been extensively studied worldwide, however, the findings have been mixed. This meta-analysis aimed to examine the global prevalence of internet addiction in university students and identify its potential moderators.

Recent Findings: A total of 101 eligible studies, comprising 128,020 participants across 38 countries and territories, were included.

Multivariable prediction of returning to work among early-onset colorectal cancer survivors in China: A two-year follow-up.

Objective: The number of early-onset colorectal cancer survivors (EOCRCs) is increasing. The primary aim of rehabilitation after battling cancer is to enable patients to return to work, as they constitute a significant contributor to societal productivity. A predictive model was developed to identify priority populations requiring intervention and refine responses to increase their capacity to return to work after undergoing treatment for EOCRC.

Functional Characterization of a Highly Efficient UDP-Glucosyltransferase CitUGT72AZ4 Involved in the Biosynthesis of Flavonoid Glycosides in Citrus.

Citrus is an important dietary source of flavonoid glycosides, and UDP-glycosyltransferases (UGTs) are the key enzymes responsible for their glycosylation. In this study, a genome-wide analysis of the gene family was conducted to identify that contribute to flavonoid 4'--glucosides biosynthesis. Our analysis identified 136 CitUGTs in the genome, classifying them into 18 phylogenetic groups (A-R) and 25 families.

Single-cell characterization of the immune heterogeneity of pulmonary hypertension identifies novel targets for immunotherapy.

Background: Pulmonary arterial hypertension (PAH) is a critical cardiopulmonary vascular disorder marked by the progressive elevation of pulmonary artery pressure, increased pulmonary vascular resistance, and eventual right heart failure. Research has shown that various immune cells play a significant role in the pathogenesis of PAH, both in patients diagnosed with the condition and in experimental models of PAH. Cell-cell communication is important for PAH progression and therapies, while the global cell landscape of intercellular signaling has not been elucidated.

New Polyketides From Trichoderma harzianum and Their Antifungal Activity.

Chemical investigation of the marine-derived fungus Trichoderma harzianum ZN-4 led to the isolation and identification of seven new secondary metabolites, harzianolides K-Q (1-7). The complete structures of seven new compounds were determined by high-resolution mass spectrometry and nuclear magnetic resonance spectroscopic analyses coupled with electronic circular dichroism calculations. The seven isolates were inactive as antibacterial and antitumor agents.

Psychosocial adjustment and influencing factors in patients with newly diagnosed colorectal cancer: A latent profile analysis.

Purpose: To identify subgroups of psychosocial adjustment among patients with newly diagnosed colorectal cancer, and to examine the inflencing factors of different subgroups.

Methods: The study surveyed 490 participants in Guangzhou from July 2022 to June 2023 using face-to-face method. The scales measured psychosocial adjustment, resilience, and coping styles.

Illness behavior and its predictors in young and middle-aged colorectal cancer patients: A latent profile analysis.

Purpose: To describe the characteristics of sick role adaptation and understand the differences in young and middle-aged colorectal cancer (CRC) patients.

Methods: 225 colorectal cancer patients aged 18-59 admitting to a specialized oncology hospital in Guangzhou, China were involved from January to April 2022. Socio-demographic characteristics, disease-related characteristics, scores of Illness Behavior Questionnaire, Hospital Anxiety and Depression Scale, the Brief Illness Perception Questionnaire, Mishel Uncertainty in Illness Scale and Medical Coping Modes Questionnaire were applied to collect quantitative data.

Small Molecular Oligopeptides Adorned with Tryptophan Residues as Potent Antitumor Agents: Design, Synthesis, Bioactivity Assay, Computational Prediction, and Experimental Validation.

Tryptophan participates in important life activities and is involved in various metabolic processes. The indole and aromatic binuclear ring structure in tryptophan can engage in diverse interactions, including π-π, π-alkyl, hydrogen bonding, cation-π, and CH-π interactions with other side chains and protein targets. These interactions offer extensive opportunities for drug development.

STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines.

Background: Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to pulmonary artery remodeling and OSA-related diseases. The immunologic factors linked to OSA-induced PH are not well understood.

A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid.

This study aims to address the challenge of detoxifying ginkgolic acid and transform it from waste into a valuable resource. By using pseudo-template molecular imprinting technology to chemically modify polysaccharide materials, we developed a polysaccharide-based molecular imprinted material (MMCC-CD/CS-MIP) for the targeted separation and controlled release of ginkgolic acid. Under optimal conditions, MMCC-CD/CS-MIP demonstrated excellent adsorption performance (Q = 47.

Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention.

New-onset atrial fibrillation (NOAF) is associated with increased morbidity and mortality. Despite identifying numerous factors contributing to NOAF, the underlying mechanisms remain uncertain. This study introduces the triglyceride-glucose index (TyG index) as a predictive indicator and establishes a clinical predictive model.

Assessment of dermal safety of petroleum ether extract from L.

(), known for its aromatic leaves and rhizomes, is extensively used in traditional medicine to treat digestive issues, inflammation, pain, anxiety, and stress. The petroleum ether extract of isolates specific bioactive compounds using petroleum ether, a nonpolar solvent effective in dissolving nonpolar plant compounds. This extract potentially offers antimicrobial, anti-inflammatory, and analgesic benefits.

Distinct trophic transfer of rare earth elements in adjacent terrestrial and aquatic food webs.

Growing demand and usage of rare earth elements (REEs) lead to significant pollution in wildlife, but trophic transfer of REEs in different food webs has not been well understood. In the present study, bioaccumulation and food web transfer of 16 REEs (La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y, and Sc) were investigated in different terrestrial and aquatic species. Median concentrations of REEs in plant, invertebrate, fish, amphibian, reptile, bird, and vole samples were 488-6030, 296-2320, 123-598, 17.

Longitudinal Trajectories of Psychological Distress and Its Influence Factors in Young and Middle-Aged Patients With Colorectal Cancer.

Aims: To identify the longitudinal trajectories of psychological distress and to explore the predictive factors of different trajectories among young and middle-aged colorectal cancer patients from diagnosis to 6 months postoperation.

Design: A longitudinal study was conducted, guided by the STROBE checklist.

Methods: A total of 214 patients were recruited from July 2021 to May 2022 at a cancer hospital in Guangzhou, China.

A nomogram model for predicting frailty in middle-aged and elderly patients with colorectal cancer:A cross-sectional study.

Purpose: Frailty is a syndrome caused by multiple factors and can lead to serious consequences for middle-aged and elderly patients with colorectal cancer. However, few studies have comprehensively explored predictors of frailty and built predictive models. Therefore, our aim is to develop and evaluate a predictive model for frailty in middle-aged and elderly patients with colorectal cancer.

SIPSC-Kac: Integrating swarm intelligence and protein spatial characteristics for enhanced lysine acetylation site identification.

Elucidation of post-translational modifications (PTMs), such as lysine acetylation (Kac), is crucial for understanding protein function and regulation. Although traditional experimental methods for identifying Kac sites are accurate, they are time-consuming and costly, leading to incomplete acetylome mapping. Computational approaches, particularly those incorporating machine learning, offer a rapid alternative, but face challenges owing to dataset imbalance, limited feature space, and the need for more effective feature-selection algorithms.

Nppb contributes to Sepsis-Induced myocardial injury by regulating Senescence-Related genes.

Background: Sepsis, a systemic inflammatory condition, is a leading cause of mortality due to cardiovascular injury. Sepsis and cellular senescence are closely related, yet the specific mechanisms are still unclear. This study aims to identify a novel therapeutic target for mitigating sepsis-induced myocardial injury.

Amlexanox reduces new-onset atrial fibrillation risk in sepsis by downregulating S100A12: a Mendelian randomization study.

Background: Sepsis is characterized by high morbidity and mortality rates, alongside limited therapeutic efficacy. Atrial fibrillation (AF), the most common arrhythmia, has been closely linked to sepsis in prior research. However, the specific mechanisms through which sepsis leads to new-onset AF remain poorly understood.