Draft genome of Roscoea Debilis, the first genome in the alpine ginger Roscoea (Zingiberaceae).

Objectives: Roscoea is a Sino-Himalayan alpine genus in pantropical family Zingiberaeae. As traditional Tibetan medicinal plants, many species of this genus are threatened by digging, logging, land clearance, grazing and climate change. Roscoea debilis is an endemic species in the Hengduan Mountains with a narrow distribution range.

Tumorigenesis and aberrant signaling in transgenic mice expressing the human herpesvirus-8 K1 gene.

Background: The K1 gene of human herpesvirus-8 (HHV-8; also known as Kaposi's sarcoma-associated herpesvirus) encodes a transmembrane signaling protein that elicits cellular activation events. To evaluate the potential role of K1 in HHV-8-associated pathogenesis, we produced transgenic mice expressing the HHV-8 K1 gene under the transcriptional control of the simian virus 40 promoter.

Methods: Three independent heterozygous transgenic K1 mouse lines were generated from founder mice.