Publications by authors named "Xiaochan Tang"
Anal Methods
February 2024
Article Synopsis
- Peroxynitrite (ONOO) is a significant reactive oxygen species (ROS) that can cause lipid peroxidation, leading to ferroptotic cell death, making its rapid detection essential for research.
- Researchers developed fluorescent probes (Rh-1, Rh-2, Rh-3) that react with ONOO, producing a strong fluorescent signal at 561 nm, with Rh-3 showing the best sensitivity and selectivity.
- Bioimaging with Rh-3 revealed that ferroptosis, triggered by erastin, increases levels of endogenous ONOO, while treatments with ferrostatin-1 and vitamin E effectively reduce ONOO production in live cells.
Anal Chim Acta
November 2022
Article Synopsis
- * A new fluorescent probe, PV1, was developed to detect viscosity changes in the ER, and it effectively demonstrates sensitivity to these changes during ferroptosis.
- * The study showed that when cells undergo ferroptosis, the viscosity of the ER increases, and certain compounds like Fer-1 and VE can inhibit this process, highlighting potential for targeted disease treatment and drug development.
