Publications by authors named "Xiaobo Tao"
Article Synopsis
- The study investigates the link between protein quantitative trait loci (pQTL-SNPs) and lung adenocarcinoma (LUAD) risk by analyzing plasma from female LUAD patients and healthy controls, along with tumor tissues.
- It identifies 7 significant pQTL-SNPs related to altered LUAD risk, showing decreased levels of certain proteins which may act as tumor suppressors in patients' plasma and tumor tissues.
- The findings suggest that mutations in 4 specific pQTL-SNPs can affect the expression of target proteins (BST1, NRP1, and APOH), influencing the risk of developing LUAD either by promoting or inhibiting tumorigenesis.
Ubiquitin modification and alternative polyadenylation play crucial roles in the onset and progression of cancer. Hence, this study aims to comprehensively and deeply understand gene regulation and associated biological processes in lung adenocarcinoma (LUAD) by integrating both mechanisms. Alternative polyadenylation (APA)-related E3 ubiquitin ligases in LUAD were identified through multiple databases, and the association between selected genetic loci influencing gene expression (apaQTL-SNPs) and LUAD risk were evaluated through the GWAS database of the Female Lung Cancer Consortium in Asia (FLCCA).
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- Alternative polyadenylation (APA) is important in understanding cancer, especially lung adenocarcinoma (LUAD).
- Researchers found that a specific gene variant (T allele of rs277646) is linked to a higher risk of LUAD and changes how the NIT2 gene works.
- The variant causes the gene to create a shorter version of itself, which can affect cancer development by altering the expression of NIT2.
Article Synopsis
- The study aimed to identify new plasma protein biomarkers for lung adenocarcinoma (LUAD) through proteomics analysis and validation in LUAD patients and healthy controls.
- GPI and PGD were found to be upregulated in LUAD patients' plasma, with a significant correlation between their plasma and tissue levels, as well as a negative correlation to tumor blood vessel normalization.
- Findings suggest GPI and PGD could serve as potential diagnostic and prognostic biomarkers, helping to assess the risk of metastasis and tumor severity in LUAD patients.
Article Synopsis
- - The study focuses on the role of NEDD4L, an E3 ubiquitin ligase, in esophageal carcinoma, revealing that lower levels of NEDD4L are linked to worse patient outcomes and faster progression of the disease.
- - Patients with higher NEDD4L expression had longer progression-free survival, and experiments confirmed that NEDD4L inhibits tumor growth and metastasis in esophageal carcinoma.
- - The research identified ITGB4 as a specific substrate for NEDD4L, showing that NEDD4L ubiquitinates and degrades ITGB4, leading to the suppression of aggressive cancer characteristics.
Article Synopsis
- The study investigates how specific single-nucleotide polymorphisms (SNPs) relate to susceptibility to silicosis using multi-omics techniques and RNA sequencing in mice.
- Twelve expression quantitative trait locus (eQTL)-SNPs were identified, with a focus on the rs419540 variant in the IL12RB1 gene, which significantly increased the risk of developing silicosis.
- Functional experiments revealed that manipulating IL12RB1 expression affected levels of pro-inflammatory factors, suggesting that rs419540 may contribute to silicosis risk by altering IL12RB1 expression.
To explore the association between apaQTL/eQTL-SNPs and the susceptibility to silicosis. A silicosis-related GWAS was initially conducted to screen for single nucleotide polymorphisms (SNPs) associated with the risk of silicosis. Candidate SNPs with apaQTL and eQTL functions were then obtained from the 3'aQTL-atlas and GTEx databases.
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- E-cigarettes are often seen as safer alternatives to regular cigarettes, but there are mixed opinions about their effects.
- More people, including teens and young adults, are using e-cigarettes for their fun flavors, but studies show that they might lead to smoking real cigarettes instead.
- While e-cigarettes may be less harmful than regular cigarettes, they still have risks, and it's important to understand their impact on health, especially in the mouth, nose, lungs, heart, and brain.
Article Synopsis
- This study investigated the consistency of mRNAs and proteins in lung adenocarcinoma (LUAD) across different populations while creating a prognostic model for better survival prediction.
- Researchers standardized various data types to find common differentially expressed mRNAs and proteins, noting that ethnic diversity affects consistency rates significantly.
- The resulting survival model, based on eight identified hub mRNAs and clinical factors, shows promise for predicting LUAD outcomes across diverse groups and highlights the importance of integrating genetic diversity in cancer research.
Article Synopsis
- Scientists are studying how a process called alternative polyadenylation (APA) affects the development of lung cancer (LUAD) and how it might help doctors predict patient outcomes.
- They found important genes connected to APA that could help tell how well patients might do, and tested these in groups from Asia and the USA.
- The research created a special tool to help predict outcomes for patients in Asia, showing it could be useful for personalizing treatment and diagnosing lung cancer better.
This study investigates the differential effects of online reviews on actual sales in cases where information regarding source identity and brand equity is accessible. The data were collected from an influential online film review platform in China. Two distinctive features of this study are: (1) source identity is expressed as "verified user" or "unverified user" according to posters' ticket payment status and (2) the interactive effect between source identity and brand equity on box-office success is examined.
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