Corrigendum: D-dencichine regulates thrombopoiesis by promoting megakaryocyte adhesion, migration and proplatelet formation.

[This corrects the article DOI: 10.3389/fphar.2018.

Corrigendum: Notoginsenoside R1 protects against diabetic cardiomyopathy through activating estrogen receptor α and its downstream signaling.

[This corrects the article DOI: 10.3389/fphar.2018.

Bioinspired Disordered Aerogel for Omnidirectional Terahertz Response.

The structural disorder of the black butterfly assists in capturing sunlight across a wider spectral and angular range, injecting infinite vitality for omnidirectional and stimuli-responsive wave-absorbing materials. Here, the disordered micro-pores responding to terahertz (THz) waves through electromagnetic simulations, and then prepared via ice templating technology are analyzed and optimized. The customized disordered aerogel makes possible perfect terahertz response property with incidence-angle-insensitive and ultra-broadband.

FGF21 ameliorates diabetic nephropathy through CDK1-dependently regulating the cell cycle.

Background: Diabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence DN progression by regulating the cell cycle in diabetic nephropathy.

Methods: In order to create a diabetic model, STZ injections were given to C57BL/6J mice for this investigation.

Correction: Wang et al. Integration of Transcriptomics and Lipidomics Profiling to Reveal the Therapeutic Mechanism Underlying (Sangzhi) Alkaloids for the Treatment of Liver Lipid Metabolic Disturbance in High-Fat-Diet/Streptozotocin-Induced Diabetic Mice. 2023, , 3914.

In the original publication [...

Efficacy of preoperative prophylactic application of betamethasone on postoperative nausea and vomiting in patients undergoing total knee arthroplasty: a prospective randomized controlled trial.

Background: The demand for total knee arthroplasty (TKA) is increasing, yet postoperative nausea and vomiting (PONV) significantly hinder patient recovery. Preoperative prophylactic administration of glucocorticoids can alleviate PONV, with betamethasone showing promising results in breast and cardiac surgeries. However, its efficacy in TKA patients remains unclear.

Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy.

Diabetic retinopathy (DR) is a blinding complication of microangiopathy. First-line therapeutic drugs are all focused on late-stage DR and have several side effects, which could not meet clinical needs. The plant-derived ginsenoside Ro (Ro) has a variety of effective anti-inflammatory, immune-regulating, and cardiovascular protective effects, but its microvascular protective effects are rarely studied.

AAUConvNeXt: Enhancing Crop Lodging Segmentation with Optimized Deep Learning Architectures.

Rice lodging, a phenomenon precipitated by environmental factors or crop characteristics, presents a substantial challenge in agricultural production, notably impacting yield prediction and disaster assessment. Despite that the application of conventional methodologies like visual assessment, mathematical models, and satellite remote sensing technologies has been employed in the segmentation of crop lodging, these approaches are still constrained in precision, immediacy, and capacity for large-scale evaluation. This study introduces an innovative convolutional neural network architecture, AFOA + APOM + UConvNeXt, that integrates intelligent optimization algorithms for automatic selection of optimal network parameters, thereby enhancing the accuracy and efficiency of crop lodging segmentation.

Non-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation.

Tubulin polyglutamylation is a posttranslational modification that occurs primarily along the axoneme of cilia. Defective axoneme polyglutamylation impairs cilia function and has been correlated with ciliopathies, including Joubert Syndrome (JBTS). However, the precise mechanisms regulating proper axoneme polyglutamylation remain vague.

Temporal dynamics of neutrophil functions in multiple sclerosis.

Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients.

Corrigendum to "Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-kB, p38, and JNK MAPK pathways" [J Ginseng Res 43 (2019) 95-104].

[This corrects the article DOI: 10.1016/j.jgr.

New drug discovery and development from natural products: Advances and strategies.

Natural products (NPs) have a long history as sources for drug discovery, more than half of approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical treatment of complex diseases. However, bioactivity screening of NPs, target identification, and design optimization require continuously improved strategies, the complexity of drug mechanism of action and the limitations of technological strategies pose numerous challenges to the development of new drugs. This review begins with an overview of bioactivity- and target-based drug development patterns for NPs, advances in NP screening and derivatization, and the advantages and problems of major targets such as genes and proteins.

The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses.

The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals. The significance of dsRNA A-to-I editing in disease development and occurrence is explored using inferential statistics and cluster analyses to investigate the enzymes involved in dsRNA editing that can catalyze editing sites across multiple biomarkers. This editing process, which occurs in coding or non-coding regions, has the potential to activate abnormal signalling pathways that contributes to disease pathogenesis.

Corrigendum: Guanxin Danshen formulation protects against myocardial ischemia reperfusion injury-induced left ventricular remodeling by upregulating estrogen receptor β.

[This corrects the article DOI: 10.3389/fphar.2017.

Multi-immunometabolomics mining: NP prevents hyperimmune in ALI by inhibiting Leucine/PI3K/Akt/mTOR signaling pathway.

Acute lung injury (ALI) is currently a global health concern. Nicandra physalodes (L.) Gaertn.

Detecting anomalous anatomic regions in spatial transcriptomics with STANDS.

Detection and Dissection of Anomalous Tissue Domains (DDATD) from multi-sample spatial transcriptomics (ST) data provides unprecedented opportunities to characterize anomalous tissue domains (ATDs), revealing both population-level and individual-specific pathogenic factors for understanding pathogenic heterogeneities behind diseases. However, no current methods can perform de novo DDATD from ST data, especially in the multi-sample context. Here, we introduce STANDS, an innovative framework based on Generative Adversarial Networks which integrates three core tasks in multi-sample DDATD: detecting, aligning, and subtyping ATDs.

Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner.

Despite the importance of cellular senescence in human health, how damaged cells undergo senescence remains elusive. We have previously shown that promyelocytic leukemia nuclear body (PML-NBs) translocation of the ciliary FBF1 is essential for senescence induction in stressed cells. Here we discover that an early cellular event occurring in stressed cells is the transient assembly of stress-induced nucleus-to-cilium microtubule arrays (sinc-MTs).