Publications by authors named "Xiaobo Sun"

The structural disorder of the black butterfly assists in capturing sunlight across a wider spectral and angular range, injecting infinite vitality for omnidirectional and stimuli-responsive wave-absorbing materials. Here, the disordered micro-pores responding to terahertz (THz) waves through electromagnetic simulations, and then prepared via ice templating technology are analyzed and optimized. The customized disordered aerogel makes possible perfect terahertz response property with incidence-angle-insensitive and ultra-broadband.

View Article and Find Full Text PDF

Background: Diabetic nephropathy (DN) is a prevalent global renal illness and one of the main causes of end-stage renal disease (ESRD). FGF21 has been shown to ameliorate diabetic nephropathy, and in addition FGF-21-treated mice impeded mitogenicity, whereas it is unclear whether FGF21 can influence DN progression by regulating the cell cycle in diabetic nephropathy.

Methods: In order to create a diabetic model, STZ injections were given to C57BL/6J mice for this investigation.

View Article and Find Full Text PDF

Background: The demand for total knee arthroplasty (TKA) is increasing, yet postoperative nausea and vomiting (PONV) significantly hinder patient recovery. Preoperative prophylactic administration of glucocorticoids can alleviate PONV, with betamethasone showing promising results in breast and cardiac surgeries. However, its efficacy in TKA patients remains unclear.

View Article and Find Full Text PDF

Diabetic retinopathy (DR) is a blinding complication of microangiopathy. First-line therapeutic drugs are all focused on late-stage DR and have several side effects, which could not meet clinical needs. The plant-derived ginsenoside Ro (Ro) has a variety of effective anti-inflammatory, immune-regulating, and cardiovascular protective effects, but its microvascular protective effects are rarely studied.

View Article and Find Full Text PDF

Rice lodging, a phenomenon precipitated by environmental factors or crop characteristics, presents a substantial challenge in agricultural production, notably impacting yield prediction and disaster assessment. Despite that the application of conventional methodologies like visual assessment, mathematical models, and satellite remote sensing technologies has been employed in the segmentation of crop lodging, these approaches are still constrained in precision, immediacy, and capacity for large-scale evaluation. This study introduces an innovative convolutional neural network architecture, AFOA + APOM + UConvNeXt, that integrates intelligent optimization algorithms for automatic selection of optimal network parameters, thereby enhancing the accuracy and efficiency of crop lodging segmentation.

View Article and Find Full Text PDF

Tubulin polyglutamylation is a posttranslational modification that occurs primarily along the axoneme of cilia. Defective axoneme polyglutamylation impairs cilia function and has been correlated with ciliopathies, including Joubert Syndrome (JBTS). However, the precise mechanisms regulating proper axoneme polyglutamylation remain vague.

View Article and Find Full Text PDF

Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients.

View Article and Find Full Text PDF

Natural products (NPs) have a long history as sources for drug discovery, more than half of approved drugs are related to NPs, which also exhibit multifaceted advantages in the clinical treatment of complex diseases. However, bioactivity screening of NPs, target identification, and design optimization require continuously improved strategies, the complexity of drug mechanism of action and the limitations of technological strategies pose numerous challenges to the development of new drugs. This review begins with an overview of bioactivity- and target-based drug development patterns for NPs, advances in NP screening and derivatization, and the advantages and problems of major targets such as genes and proteins.

View Article and Find Full Text PDF

The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals. The significance of dsRNA A-to-I editing in disease development and occurrence is explored using inferential statistics and cluster analyses to investigate the enzymes involved in dsRNA editing that can catalyze editing sites across multiple biomarkers. This editing process, which occurs in coding or non-coding regions, has the potential to activate abnormal signalling pathways that contributes to disease pathogenesis.

View Article and Find Full Text PDF
Article Synopsis
  • L-NRB is a compound derived from butylphthalide and borneol that was studied for its potential benefits in treating amyotrophic lateral sclerosis (ALS).
  • Researchers used SOD1-G93A mice as a model for ALS, conducting various tests to evaluate the compound's therapeutic effects and its mechanisms.
  • The study found that L-NRB improved motor function and reduced damage in motor neurons by inhibiting neuroinflammation and regulating a specific signaling pathway, indicating its potential as a treatment for ALS.
View Article and Find Full Text PDF
Article Synopsis
  • Ginseng Radix et Rhizoma is a traditional Chinese herbal medicine with a rich history, healthcare benefits, and cultural significance in China.
  • The industry surrounding it is important for the evolution of traditional Chinese medicine (TCM) and is currently facing new opportunities as well as challenges that need addressing.
  • This article reviews the Ginseng Radix et Rhizoma industry in China, highlighting its industrial chain, current issues, and future trends, to guide its high-quality development.
View Article and Find Full Text PDF

Detection and Dissection of Anomalous Tissue Domains (DDATD) from multi-sample spatial transcriptomics (ST) data provides unprecedented opportunities to characterize anomalous tissue domains (ATDs), revealing both population-level and individual-specific pathogenic factors for understanding pathogenic heterogeneities behind diseases. However, no current methods can perform de novo DDATD from ST data, especially in the multi-sample context. Here, we introduce STANDS, an innovative framework based on Generative Adversarial Networks which integrates three core tasks in multi-sample DDATD: detecting, aligning, and subtyping ATDs.

View Article and Find Full Text PDF
Article Synopsis
  • Astragali Radix (AR) is a traditional Chinese herbal remedy used for chronic heart failure, with two main types available: 5-year old (5YAR) and 2-year old (2YAR), but their effectiveness needs more research.
  • The study aimed to compare the chemical compositions and protective effects of both types of AR on heart failure, using ethanol extracts in mouse models.
  • Results showed that 5YAR had higher levels of saponins and flavonoids but lower polysaccharides compared to 2YAR, and both types helped prevent heart damage caused by inducing heart failure.
View Article and Find Full Text PDF

Despite the importance of cellular senescence in human health, how damaged cells undergo senescence remains elusive. We have previously shown that promyelocytic leukemia nuclear body (PML-NBs) translocation of the ciliary FBF1 is essential for senescence induction in stressed cells. Here we discover that an early cellular event occurring in stressed cells is the transient assembly of stress-induced nucleus-to-cilium microtubule arrays (sinc-MTs).

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiona9pi14r3kur1l0abua25fc2q42svdrhe): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once