"Calabash Vine" Nanoassembly for Chemotherapy and Photothermal Combination Therapy of Breast Cancer.

DNA nanoassembly-loaded CFA@SD core-shell nanoparticles and doxorubicin (Dox) were constructed based on the rolling circle amplification reaction (RCA), which is called CFA@RD NAs. CFA NPs was prepared by coating a gold nanoshell on the surface of FeO NPs modified with citrate. Then, single-stranded DNA (SD, partial sequence is complementary to RCA) was further modified on the surface of CFA NPs through a gold-sulfur bond to synthesize CFA@SD NPs.

Large-capacity DNA vectors based on rolling circle amplification with multivalent aptamers delivery copper sulfide for the synergistic treatment of Cancer through chemo/Photothermal/Chemodynamic therapy in vitro.

Developing multifunctional nanomedicines represents a frontier. We have engineered a high-capacity DNA vector basing rolling circle amplification for the delivery of copper sulfide nanoparticles (CuS NPs) and doxorubicin (DOX), coupled with multivalent aptamers (MA) that precisely target tumors, culminating in a multifunctional nanoplatform (RMALCu@DOX), which combines the chemotherapy (CT)/photothermal therapy (PTT)/chemodynamic therapy (CDT). The vector (RMAL) boasts exceptional biocompatibility and incorporates multiple copy units, enabling the precise loading of numerous CuS NPs, forming RMALCu which possesses a robust photothermal effect and superior Fenton-like catalytic activity, heralding a project of minimally invasive dual-mode (PTT/CDT) therapy.

Discrimination of normal/cancer cells in bioimaging through a rolling circle amplification-enhanced red carbon dots-embedded multivalent aptamers nanoplatform.

Glutathione (GSH) is a key biomarker closely associated with cancer, and its content varies greatly between normal cells and cancer cells. However, intracellular detection of GSH was challenging because existing probes not only have a long detection time but also have fluorescence in the blue-green region that overlaps with the biological matrix's spontaneous fluorescence, thus affecting the detection accuracy. Therefore, a new red fluorescent nano-probe was needed to rapidly and accurately detected GSH within the biological matrix.

A Multifunctional DNA Nanoassembly for Cancer Cell Detection and Combined Gene-Chemotherapy Therapy.

Although DNAzyme is a promising gene therapy agent, low cellular uptake efficiency, poor biological stability, and the unsatisfactory effect of monotherapy limit its development. Herein, a multifunctional DNA nanoassembly (RCA product-aptamer-DNAzyme, RAD) was constructed for cancer cell detection and targeted delivery of doxorubicin (DOX) and DNAzyme. Briefly, the rolling circle amplification (RCA) product was employed as a scaffold, and each repeated sequence was designed to combine with three single-stranded DNA (ssDNA), which carried the aptamer AS1411 sequence, fluorescent group, and DNAzyme sequence, respectively.

Multifunctional Ru(III)/FeO/DNA nanoplatform for photothermal-enhanced photodynamic and chemodynamic cancer therapy.

Among the many cancer treatment methods, there have been many reports on the use of nanoplatforms with single treatment methods such as photothermal, photodynamic or chemodynamic for cancer treatment. In this study, Ru(III) with photodynamic effect and FeO nanoparticles with photothermal and chemodynamic effects are connected through long DNA chains with efficient active targeting rolling circle amplification to construct Ru(III)/FeO/DNA nano-platform realizes the combination of photothermal, photodynamic and chemodynamic treatment, which significantly improves the therapeutic effect of the nano-platform. Its multiple active targeting capabilities reduce the damage to normal cells.

The switch of the DNA tetrahedral tweezers controlled by mercury ions.

In this paper, the one-pot method is used to make the four DNA strands complement each other to construct the basic framework for DNA tetrahedral tweezers. To regulate the opening and closing of DNA tetrahedral tweezers, DNA strands with a high amount of T-base sequences is partially complementary to the tetrahedral framework. Hg can form T-Hg-T hairpin structures with T-base.

Solar-Driven Production Of Hydrogen Peroxide And Benzaldehyde In Two-Phase System By An Interface-Engineered Co S -CoZnIn S Heterostructure.

Coupling the photoproduction of solar fuel and value-added chemicals is highly attractive, as it maximizes the utilization of incident sunlight and the economic value of photocatalytic reactions. Constructing intimate semiconductor heterojunction for these reactions is highly desirable due to accelerated charge separation at the interfacial contact, but is challenged by material synthesis. Here, an active heterostructure bearing intimate interface, consisting of discrete Co S nanoparticles anchored on cobalt doped ZnIn S using a facile in situ one-step strategy, can drive photocatalytic co-production of H O and benzaldehyde from a two-phase water/benzyl alcohol system with spatial product separation is reported.

Photothermal-enabled single-atom catalysts for high-efficiency hydrogen peroxide photosynthesis from natural seawater.

Hydrogen peroxide (HO) is a powerful industrial oxidant and potential carbon-neutral liquid energy carrier. Sunlight-driven synthesis of HO from the most earth-abundant O and seawater is highly desirable. However, the solar-to-chemical efficiency of HO synthesis in particulate photocatalysis systems is low.

Diagnostic Performance of Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging in Differentiating Recurrence From Radiation Injury in Postoperative Glioma: A Meta-analysis.

Purpose: It is important to differentiate between radiation injury (RI) and tumor recurrence (TR) in patients with glioma after surgery and radiotherapy. Our objective was to evaluate the use of dynamic susceptibility contrast-enhanced perfusion-weighted imaging to distinguish between TR and RI in patients with glioma.

Methods: Relevant studies published until October 2021 were identified in the PubMed, Embase, and Cochrane Library databases.

Transition Metal Engineering of Molybdenum Disulfide Nanozyme for Biomimicking Anti-Biofouling in Seawater.

Nature has evolved diverse strategies to battle surface biofouling colonization and thus provides us novel insights into designing and developing advanced nontoxic antibiofouling materials and technologies. Mimicking the defense mechanisms of natural haloperoxidases in marine algae in response to biofilm colonization, here we show that the less active MoS shows efficient haloperoxidase-mimicking activity through judicious transition metal engineering. Cobalt-doped MoS (Co-MoS) displays an excellent haloperoxidase-mimicking performance in catalyzing the Br oxidation into germicidal HOBr, roughly 2 and 23 times higher than the nickel-doped MoS and pristine MoS, respectively.

Stabilizing Ultrasmall Ceria-Cluster Nanozyme for Antibacterial and Antibiofouling Applications.

The generation of undesired biofouling in medical and engineering applications results in a reduction in function and durability. Copying functionalities of natural enzymes to combat biofouling by artificial nanomaterials is highly attractive but still challenged by the inferior catalytic activity and specificity principally because of low densities of active sites. Here, an innovate strategy is demonstrated to stabilize high-density ultrasmall ceria clusters on zirconia for biofouling prevention.

Atomic Chromium Coordinated Graphitic Carbon Nitride for Bioinspired Antibiofouling in Seawater.

Artificial nanozymes exerting enzyme functionality are recognized as promising alternatives of natural enzymes in biomimetic chemistry. Natural haloperoxidases that utilize hydrogen peroxide (H O ) to catalytically convert halide into strong biocidal hypohalous acid hold great promise for thwarting biofouling, while their practical application remains highly questionable as instability of natural enzymes and inadequate H O . Herein a semiconducting nanozyme consisting of chromium single atoms coordinated on carbon nitride (Cr-SA-CN) that performs bifunctional roles of nonsacrificial H O photosynthesis and haloperoxidase-mimicking activity for antibiofouling is constructed.

I-125 seed-loaded versus normal stent insertion for obstructive esophageal cancer: a meta-analysis.

Introduction: Malignant esophageal obstruction is usually caused by esophageal and other chest cancers. More than 80% of cases of obstructive esophageal cancer (OEC) have lost the chance of curative resection. Stent insertion is a first-line palliative approach used to treat incurable OEC.

Computed tomography-guided cutting needle biopsy for lung nodules: A comparative study between low-dose and standard dose protocols.

We aim to compare the diagnostic accuracy, safety, and radiation exposure between low-dose and standard-dose computed tomography (CT)-guided cutting needle biopsy (CNB) for lung nodules.From January 2016 to August 2017, all consecutive patients admitted with lung nodule underwent low-dose or standard-dose CT-guided CNB procedure in our center. Diagnostic accuracy and radiation dose were compared.

Endovascular stent repair of celiac arterial aneurysm.

The aim of this study was to evaluate the safety and clinical effectiveness of endovascular stent repair of celiac arterial aneurysm (CAA).From January 2015 to December 2018, 11 patients (7 males, 4 females with a mean age of 52.2 ± 7.