Publications by authors named "Xiaobing Hong"
Article Synopsis
- C. elegans is a tiny worm that scientists use to test how well drugs work, but figuring out how drugs move around in these worms can be tricky.
- This study created a special version of a compound called leonurine that glows under a certain light, which helps track how the drug gets into the worm and other types of cells.
- The researchers showed that this glowing drug sticks to specific proteins in both worms and mammalian cells, making it easier to see and measure how much drug is present, which can help with future drug studies.
Article Synopsis
- - This study focuses on identifying multidrug-resistant (MDR) bacteria that avoided detection in automated laboratories, specifically in two hospitals in Shenzhen, China, from 2015 to 2017.
- - Researchers used PCR techniques and sequencing to confirm the identity of five bacterial isolates, discovering that three were resistant to carbapenem antibiotics and carried specific drug-resistance genes.
- - The findings indicate that traditional automated identification systems struggle to differentiate these isolates from similar bacteria, highlighting the need for PCR-based methods for accurate detection and classification.
Article Synopsis
- In China, kids are spending a lot more time on screens, which worries parents and experts about how it affects their development.
- A study looked at 42,841 kids under 3 years old to see if too much screen time relates to hyperactive behaviors.
- The results showed that kids who watch more than 90 minutes of screen time daily are more likely to be hyperactive compared to those who watch less.
Background: Vancomycin remains a first-line treatment drug as per the treatment guidelines for methicillin-resistant (MRSA) bacteremia. However, a number of gram-positive cocci have developed resistance to several drugs, including glycopeptides. Therefore, there is an urgent need for effective and innovative antibacterial drugs to treat patients with infections caused by drug-resistant bacteria.
View Article and Find Full Text PDFFibroblast growth factor 2 (FGF2) is a multifunctional cell growth factor that regulates cell proliferation, differentiation, adhesion, migration, and apoptosis. FGF2 has multiple isoforms, including an 18-kDa low molecular weight isoform (lo-FGF2) and 22-, 23-, 24-, and 34-kDa high molecular weight isoforms (hi-FGF2). Hi-FGF2 overexpression induces chromatin compaction, which requires the mitochondria and leads to apoptosis.
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