Correlation analysis between plasma fibrinogen and nerve electrophysiological changes in type 2 diabetic peripheral neuropathy.

Introduction: The aim of the study was to investigate the pathogenesis of diabetic peripheral neuropathy (DPN) and the value of fibrinogen (FIB) in the early diagnosis of DPN.

Material And Methods: A total of 121 patients with type 2 diabetes mellitus (T2DM) and DPN hospitalized in the Endocrinology Department of the 923 Hospital of the People's Liberation Army of China were randomly selected between May and October 2020 and divided into a T2DM asymptomatic (no peripheral neuropathy-related symptoms) group (66 cases) and a T2DM symptomatic group (55 cases) according to the presence or absence of clinical neurological symptoms and signs. Forty healthy volunteers were selected as a normal control group.

Role of Fibrinogen in Type-2 Diabetes Mellitus with Diabetic Neuropathy and its Preliminary Mechanism.

Introduction: Diabetic peripheral neuropathy (DN) is the most common complication of type 2 diabetes mellitus (T2DM).

Objective: This study aimed to explore the role of fibrinogen (FIB) in T2DM neuropathy and its preliminary mechanism.

Methods: Ten male Sprague-Dawley rats were divided into a normal control group (NC group) and a T2DM neuropathy model group (DN group).

A novel deep feature transfer-based OSA detection method using sleep sound signals.

Objective: Polysomnography is typically used to evaluate the severity of obstructive sleep apnea (OSA) but the inconvenience of application and high cost considerably affect the diagnostics. In this study, sleep sound signals are used to detect OSA in patients.

Approach: A deep feature transfer-based OSA detection approach is proposed.

Motor imagery EEG classification based on ensemble support vector learning.

Background And Objective: Brain-computer interfaces build a communication pathway from the human brain to a computer. Motor imagery-based electroencephalogram (EEG) classification is a widely applied paradigm in brain-computer interfaces. The common spatial pattern, based on the event-related desynchronization (ERD)/event-related synchronization (ERS) phenomenon, is one of the most popular algorithms for motor imagery-based EEG classification.

Integration of cell-free protein synthesis and purification in one microfluidic chip for on-demand production of recombinant protein.

Recombinant proteins have shown several benefits compared with their non-recombinant counterparts in protein therapeutics. However, there are still some problems with the storage and distribution of recombinant proteins, owing to their temperature sensitivity. Microfluidic chips can integrate different functional modules into a single device because of the advantages of integration and miniaturization, which have the special potential to synthesize drugs when and where they are needed most.

Candida skin testing is a poor adjunct to tuberculin skin testing in international adoptees.

We conducted a prospective longitudinal study evaluating Candida skin testing among international adoptees presenting to our clinic between 2000 and 2006. Nineteen (17%) and 17 (15%) children had negative tests at presentation and at 6 months, respectively--only 3 were negative at both points. Our study suggests that Candida skin test reactivity is an unstable measure of anergy among international adoptees.

Predictive value of immunization records and risk factors for immunization failure in internationally adopted children.

Objectives: To measure the predictive value of immunization records for protective immunity and identify risk factors for immunization failure.

Design: Prospective cross-sectional study, 2001-2006.

Setting: International Adoption Clinic, Rainbow Babies and Children's Hospital, Cleveland, Ohio.

Sleep duration and biomarkers of inflammation.

Introduction: Extremes of sleep duration have been associated with adverse health outcomes. The mechanism is unclear but may be related to increased inflammation. We sought to assess the association between sleep duration and inflammatory biomarkers.

Association between short sleeping hours and overweight in adolescents: results from a US Suburban High School survey.

Insufficient sleep may lead to adverse health effects, influencing body weight. This study quantified the prevalence of short sleep and the association between sleep duration and overweight in a sample of suburban students. Cross-sectional study was conducted in 2004, involving 529 students from Bay High School, Bay Village, OH, USA, using self-administered questionnaires assessing lifestyle and sleep behaviors.

Backward estimation of exposure to organochlorines using repeated measurements.

Great Lakes sport-caught fish are contaminated with various organochlorines (OCs) such as polychlorinated biphenyls (PCBs). Through consumption of these fish, humans are subject to continuing levels of OC contamination. To assess potential adverse effects of past exposure, we compared three different backward extrapolation models.

Maternal concentration of polychlorinated biphenyls and dichlorodiphenyl dichlorethylene and birth weight in Michigan fish eaters: a cohort study.

Background: Studies on maternal exposure to polychlorinated biphenyls (PCBs) reported inconsistent findings regarding birth weight: some studies showed no effect, some reported decreased birth weight, and one study found an increase in weights. These studies used different markers of exposure, such as measurement of PCBs in maternal serum or questionnaire data on fish consumption. Additionally maternal exposures, such as dichlorodiphenyl-dichloroethylene (DDE), which are related to PCB exposure and may interfere with the PCB effect, were rarely taken into account.