Publications by authors named "Xiaobei Wei"
Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice.
J Cachexia Sarcopenia Muscle
October 2024
Background: Aging negatively impacts tissue repair, particularly in skeletal muscle, where the regenerative capacity of muscle stem cells (MuSCs) diminishes with age. Although aerobic exercise is known to attenuate skeletal muscle atrophy, its specific impact on the regenerative and repair capacity of MuSCs remains unclear.
Methods: Mice underwent moderate-intensity continuous training (MICT) from 9 months (aged + Ex-9M) or 20 months (aged + Ex-20M) to 25 months, with age-matched (aged) and adult controls.
Article Synopsis
- Scientists studied how muscles can get weaker from things like not moving for a long time (like in space or being bed-ridden).
- They used electrical stimulation (ES) to help prevent muscles from getting weak and tried mixing different stimulation frequencies to see what works best.
- They found that using high-frequency stimulation helped the muscles stay stronger and grow better, even when the rats were not active for a while.