Role of del Nido Cardioplegia Solution in Prolonged Aortic Cross-clamp Cardiac Surgery: A Prospective Study.

Objectives: The myocardial-protective effect of del Nido cardioplegia solution was evaluated in adult patients undergoing prolonged aortic cross-clamping during cardiac surgery.

Design: Prospective cohort.

Setting: Single-center tertiary academic medical center.

Circulating Tumor Cells Culture: Methods, Challenges, and Clinical Applications.

Circulating tumor cells (CTCs) play a pivotal role in cancer metastasis and hold considerable potential for clinical diagnosis, therapeutic monitoring, and prognostic evaluation. Nevertheless, the limited quantity of CTCs in liquid biopsy samples poses challenges for comprehensive downstream analysis. In vitro culture of CTCs can effectively address the issue of insufficient CTC numbers.

Photoinduced Concerted Fragmentation of Alkyl -Phthalimidoyl Oxalates: Mechanisms and Applications.

In this work, we used experiments and density functional theory calculations to investigate the mechanism and driving forces of the reductive fragmentation of NHPI esters. Mechanistic studies suggest that the fragmentation behavior of the NHPI ester is influenced not only by the electronic nature of the substituent group but also by the stability of the radical intermediate. To further investigate this transformation, we next examined the aminoalkoxycarbonylation of alkenes using alkyl -phthalimidoyl oxalates.

Protective environment strategies for hematopoietic stem cell transplantation: progress and prospects.

With the progress of hematopoietic stem cell transplantation technology, the reduction of pretreatment intensity, the shortening of bone marrow suppression time and the reduction of infection risk, as well as the prominent physical and psychological stress for doctors and patients caused by rigorous protection procedures, the strategies for protective environment need to be reconsidered. Regardless of whether total environment protection is implemented, there is no significant difference in the outcomes of chemotherapy patients with neutropenia. The advantages and disadvantages of total environment protection have been weighed and reviewed for patients receiving hematopoietic stem cell transplantation.

Risk Factors and a Prediction Model for Hemorrhagic Transformation in Acute Ischemic Stroke With Atrial Fibrillation.

Objectives: To identify the risk factors of hemorrhagic transformation (HT) and to establish a prediction model for HT in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF).

Methods: From January 2015 to December 2018, patients with AIS and AF were enrolled. Demographics, lesion features, and blood test results were collected.

Radiated and conducted research on damage characteristics of digital protective relays in substations under high-altitude electromagnetic pulse environment.

This paper presents the damage characteristics of digital protective relays (DPR) in substations under high-altitude electromagnetic pulse (HEMP) environments through radiated and conducted tests. Three representative substation circuits of DPR are selected, and the radiated and conducted experiments are performed. Through a comprehensive analysis of the radiated and conducted test results, the damage characteristics of DPRs under the HEMP environment are determined, including port coupling characteristics and vulnerability, respectively.

Site-Specific Dehydrogenative Hydroxyfluoroalkylation of Indoles with Hexafluoroisopropanol.

An efficient and convenient method for the synthesis of C3-hydroxytrifluoroalkylated indoles and pyrroles was described in this paper. The copper-catalyst-free site-specific cross-dehydrogenative coupling reaction of various indoles and pyrroles with hexafluoroisopropanol proceeded smoothly by using MnO as oxidant to furnish a hydroxytrifluoroalkylated electron-rich -heterocycle in satisfactory to excellent yields. Various groups, including the synthetically useful functional groups Cl, NO, and CN, were tolerated well.

Longitudinal ultra-sensitive mutation burden sequencing for precise minimal residual disease assessment in AML.

Relapse is one of the major challenges in clinical treatment of acute myeloid leukemia (AML). Though minimal residual disease (MRD) monitoring plays a crucial role in quantitative assessment of the disease, molecular MRD analysis has been mainly limited to patients diagnosed with gene fusions and NPM1 mutations. Here, we report a longitudinal ultra-sensitive mutation burden (UMB) monitoring strategy for accurate MRD analysis in AML patients regardless of genetic abnormality types.

A quasi-experimental study on couple-based exercise program improving cardiac rehabilitation exercise compliance in post-PCI patients.

Background: Percutaneous coronary intervention (PCI) helps treat coronary artery disease but only provides short-term relief and doesn't stop disease progression. Exercise rehabilitation can improve outcomes for patients after PCI and lower the risk of death and new heart problems, but many patients struggle to stick with their exercise routines. Spouses play a crucial role in supporting patients and helping them stay committed to their rehabilitation.

Tenecteplase thrombolytic therapy for acute ischaemic stroke in China: a real-world, multicentre, retrospective, controlled study.

Background And Aims: Tenecteplase (TNK) offers logistical advantages in stroke thrombolytic therapy with its single bolus administration compared with alteplase. We aim to investigate the real-world evidence regarding its safety and effectiveness in China.

Methods: We conducted a retrospective study on patients receiving alteplase or TNK for acute ischaemic stroke (AIS) within 4.

Research Trends and Hotspots of Big Data in Ophthalmology: A Bibliometric Analysis and Visualization.

Purpose: The burst of modern information has significantly promoted the development of global medicine into a new era of big data healthcare. Ophthalmology is one of the most prominent medical specialties driven by big data analytics. This study aimed to describe the development status and research hotspots of big data in ophthalmology.

Effect of aeration on oxygen transfer characteristics in integrated wastewater treatment systems utilizing mass transfer model and computation fluid dynamics methods.

This paper investigates the aeration and oxygen transfer characteristics within the aeration tank of an integrated wastewater treatment system (IWTS) using Computational Fluid Dynamics coupled with Population Balance Model and oxygen transfer model. The findings suggest that increasing the air flow rate significantly enhances the oxygen transfer rate, albeit at a decreasing rate of growth. The oxygen overall mass transfer coefficient is primarily influenced by the interfacial area per unit volume and to a lesser by the oxygen mass transfer coefficient (k).

White matter microstructure damage measured by automated fiber quantification correlates with pain symptoms in lung cancer patients.

To investigative the white matter (WM) alterations in lung cancer patients with cancer pain (CP+), and explore the correlations between damaged WM fiber tracts and clinical indicators. Twenty-six CP+, 26 lung cancer patients without CP (CP-), and 31 healthy controls (HC) were recruited. All participants underwent diffusion tensor imaging (DTI) and clinical assessments.

Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways.

African swine fever (ASF), caused by the African swine fever virus (ASFV), has resulted in significant losses in the global pig industry. Considering the absence of effective vaccines, developing drugs against ASFV may be a crucial strategy for its prevention and control in the future. In this study, punicalagin, a polyphenolic substance extracted from pomegranate peel, was found to significantly inhibit ASFV replication in MA-104, PK-15, WSL, and 3D4/21 cells by screening an antiviral compound library containing 536 compounds.

Safety evaluation of extracorporeal shockwave lithotripsy for pancreatic stones: Experience based on a large chronic pancreatitis cohort.

Background: The safety of extracorporeal shock wave lithotripsy for pancreatic stones (P-ESWL) and adverse events were not evaluated and classified within large sample population. This study aimed to evaluate the safety and classify the adverse events of P-ESWL based on a large sample cohort.

Methods: This is an observational study based on the large prospective chronic pancreatitis (CP) cohort.

A 700 kV pulse generator with a rise time on the order of several nanoseconds.

Pulse generators with high voltage and several nanoseconds of rise time are typically used to carry out the equivalent assessment of the protection performance of typical power equipment in the high-altitude electromagnetic pulse environment. In this paper, a pulse generator with high voltage and fast rise time has been designed, and the diagnostic system with high temporal resolution has been integrated to measure the output pulse voltage of the generator. The experimental results showed that the output pulse voltage of the generator on the output load can reach 645 kV when the charged voltage of Marx generator capacitors is 40 kV.

Predeposit Autologous Blood Donation in Rh(D)-Negative Pregnant Women: A Single-Center Study.

 The primary purpose of this study was to assess the practicability of predeposit autologous blood donation (PABD) in the practice of Rh(D)-negative pregnant women.  A cohort of 405 Rh(D)-negative pregnant women who had a delivery in the comprehensive tertiary hospital in Nanjing was analyzed retrospectively, over 10 years.  After PABD, 203 women experienced a slight drop in mean hemoglobin of 5.

The leakage field characteristics of a large hybrid electromagnetic pulse simulator.

The leakage field of a hybrid electromagnetic pulse simulator with horizontal polarization is simulated and experimentally investigated based on the finite integration technique in this paper. The field distribution characteristics and far-field radiation pattern of the simulator are given. The attenuation characteristics of the electric field at specific directions in the z = 2 m plane are also predicted by numerical data fitting.