Publications by authors named "XiaoYu Yuan"

Bisphenol A (BPA) and its substitute, Bisphenol S (BPS) are typical endocrine-disrupting chemicals used in plastics, but their cancer-promoting effect has remained controversial. Here, we investigated the effects of environmentally relevant doses of BPA/BPS exposure on the tumor microenvironment (TME) in ovarian cancer. BPA exposure levels was exhibiting a declining trend and BPS showing an ascending trend in the female population by analyzing the NHANES data (2013-2016).

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The publication of several high-quality genomes has contributed greatly to clarifying the evolution of citrus. However, due to their complex genetic backgrounds, the origins and evolution of many citrus species remain unclear. We assembled de novo the 294-Mbp chromosome-level genome of a more than 200-year-old primitive papeda (DYC002).

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An exploration of antibacterial components from the whole plant of Euphorbia humifusa led to the isolation of 14 new triterpenoids, euphohumifusoids A-N (1-7 and 9-15), as well as four known analogues (8 and 16-18). Their structures were elucidated by extensively analysis of the spectroscopic data and X-ray crystallography using Cu Kα radiation. Among them, euphohumifusoid A (1) bears an unique 6(7 → 8)abeo scaffold originated from a D:C-friedo-oleanane skeleton for the first time, euphohumifusoids H and I (9 and 10) possess a rare α,β-unsaturated-γ-lactone chain originated from 25,26,27-trinordammaranes, and euphohumifusoid L (13) is a highly modified 3,4-seco-25,26,27-trinorcycloartane.

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  • Clinical trials targeting a specific molecular pathway have been ineffective in treating Alzheimer's disease, highlighting the need to address the effects of Aβ protein aggregation and neuroinflammation.
  • Researchers designed a nano-sized flower mesoporous selenium carrier that delivers metformin (a diabetes drug) to the brain by targeting transferrin receptors, facilitating transport across the blood-brain barrier.
  • In animal models, this system not only released metformin effectively at the site of Alzheimer's lesions but also promoted neuroprotection and improved cognitive function by reducing Aβ deposits and enhancing microglial activity.
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  • Perfluorodecanoic acid (PFDA) is a common environmental contaminant linked to various toxic effects in humans, particularly through exposure pathways like the food chain.* -
  • Our study demonstrated that PFDA exposure triggers inflammation in macrophages by activating specific molecular pathways (cGAS/STING/NF-κB) in laboratory settings.* -
  • In an inflammatory bowel disease mouse model, PFDA was shown to worsen intestinal inflammation, underscoring the potential health risks of PFDA exposure and the need for better management strategies.*
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Mitochondrial dysfunction in microglia has been implicated as a key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). Abnormal production of reactive oxygen species (ROS) and neuroinflammation caused by mitochondrial oxidative stress are important factors leading to neuronal death in AD. Herein, a "dual brake" strategy to synergistically halt mitochondrial dysfunction and neuroinflammation targeting mitochondria in microglia is proposed.

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Wheat dwarf virus (WDV, genus , family ) is one of the causal agents of wheat viral disease, which severely impacts wheat production in most wheat-growing regions in the world. Currently, there is little information about natural resistance against WDV in common wheat germplasms. CRISPR/Cas9 technology is being utilized to manufacture transgenic plants resistant to different diseases.

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  • PFBS, a chemical in the PFAS group, is being used as an alternative to PFOS, but may contribute to health issues, particularly in aging.
  • Research using C. elegans showed that PFBS exposure leads to impaired healthspan and may activate aging mechanisms linked to dysfunction in the pink-1 mediated mitophagy pathway.
  • Treatment with Urolithin A, a mitophagy booster, was able to reverse the negative effects of PFBS and improve healthspan, suggesting that enhancing mitophagy could be a potential approach to combat PFBS-related aging.
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  • PFNA is being increasingly used as a substitute for PFOS and PFOA, but its effects on cancer, particularly ovarian cancer, have been underexplored.
  • Research showed that exposure to PFNA at environmental levels (0.25-2 mM) didn’t affect cell growth but significantly increased the invasion and migration of ovarian cancer cells, linked to changes in EMT markers.
  • The study identified that PFNA activates the TGF-β/SMADs pathway by degrading SMAD7 through the ubiquitin-proteasome system, highlighting its role in promoting ovarian cancer metastasis.
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  • This study explored the use of chitosan, a natural and biodegradable material, to improve the preservation of perishable foods through the development of chitosan-based composite membranes.
  • Researchers modified lignin with a solvent fractionation method and clinoptilolite zeolite using alkali modification, ultimately finding that specific combinations of modified lignin (ML3) and zeolite (MCZ3) enhanced the properties of chitosan membranes.
  • The improved composite membranes demonstrated better light transmittance, antioxidant activity, and gas selectivity, leading to more effective preservation of foods like bananas, cherry tomatoes, and cheeses, indicating the potential for eco-friendly packaging solutions.
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  • - The MnBiTe-(BiTe) superlattice is a promising material that integrates topology and magnetism with low structural disorder, enabling effective study of magnetic properties.
  • - Researchers found that ferromagnetic (FM) and antiferromagnetic (AFM) orders in this system can be controlled by adjusting either the Mn-Mn distance or the BiTe/MnBiTe ratio.
  • - Their findings reveal that AFM order relies solely on the Mn-Mn distance, while FM order depends only on the BiTe/MnBiTe ratio, offering pathways to manipulate magnetic orders in similar materials.
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  • Perfluoroundecanoic acid (PFDA), commonly used in textiles and food processing, may enhance tumor growth by altering the tumor microenvironment, particularly through its effect on macrophages.
  • Research showed that PFDA-treated macrophages (RAW264.7) shifted to a tumor-promoting M2 phenotype, linked to the activation of β-catenin and its movement into the cell nucleus.
  • Additionally, conditioned medium from PFDA-treated macrophages boosted ovarian cancer cell migration and invasion, and in vivo studies indicated that PFDA facilitated tumor metastasis, which was reduced by a β-catenin inhibitor.
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Background: Postoperative acute kidney injury (AKI) after lung transplantation (LTx) is an important factor affecting the short-term outcomes. The focus item of transplantation centers is how to improve the incidence of AKI through optimal management during the perioperative period.

Objective: The purpose of the study is to investigate the influence of perioperative volume in the development of early AKI following LTx.

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Highly crystalline and easily feasible topological insulator-superconductor (TI-SC) heterostructures are crucial for the development of practical topological qubit devices. The optimal superconducting layer for TI-SC heterostructures should be highly resilient against external contamination and structurally compatible with TIs. In this study, we provide a solution to this challenge by showcasing the growth of a highly crystalline TI-SC heterostructure using refractory TiN (111) as the superconducting layer.

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Here, we report a novel wheat-infecting marafivirus, tentatively named "Triticum aestivum marafivirus" (TaMRV). The full-length genome sequence of TaMRV comprises 6,437 nucleotides, excluding the poly(A) tail. Pairwise sequence comparisons and phylogenetic analysis revealed that TaMRV may represent a novel species within the genus Marafivirus in the family Tymoviridae.

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Objectives: This study aimed to evaluate the effectiveness of the Trauma Rating Index in Age, Glasgow Coma Scale, Respiratory rate and Systolic blood pressure score (TRIAGES) in predicting 24-hour in-hospital mortality among patients aged 65 years and older with isolated traumatic brain injury (TBI).

Design: A retrospective, single-centre cohort study.

Setting: This study was conducted at a government-run tertiary comprehensive hospital.

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Hypoxia, as a prevalent feature of solid tumors, is correlated with tumorigenesis, proliferation, and invasion, playing an important role in mediating the drug resistance and affecting the cancer treatment outcomes. Due to the distinct oxygen levels between tumor and normal tissues, hypoxia-targeted therapy has attracted significant attention. The hypoxia-activated compounds mainly depend on reducible organic groups including azo, nitro, N-oxides, quinones and azide as well as some redox-active metal complex that are selectively converted into active species by the increased reduction potential under tumor hypoxia.

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Protein glycosylation research is currently focused on the development of various functionalized materials that can effectively enrich the levels of glycopeptides in samples. However, most of these materials possess limited glycopeptide-specific recognition sites because of large steric hindrance, unsuitable mass transfer kinetics, and relatively low surface areas. Herein, a highly hydrophilic two-dimensional (2-D) metal-organic framework (MOF) nanosheet modified with glutathione (GSH) and l-cysteine (l-Cys) (denoted as Zr-Fc MOF@Au@GC) has been synthesized for efficient glycopeptide enrichment.

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Hypobaric hypoxia (HH) exposure affects appetite and serum iron levels in both humans and animals. Thus, whether appetite-regulating ghrelin is involved in iron regulation under HH needs to be elucidated. In vivo, C57BL/6J mice were placed in a hypobaric chamber to establish a 6000-m-high altitude exposure animal model.

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Background: Ovarian cancer is commonly associated with a poor prognosis due to metastasis and chemoresistance. PINK1 (PTEN-induced kinase 1) is a serine/threonine kinase that plays a crucial part in regulating various physiological and pathophysiological processes in cancer cells.

Methods: The ATdb database and "CuratedOvarianData" were used to evaluate the effect of kinases on ovarian cancer survival.

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Benzo[a]pyrene (BaP) is commonly found in the environment as a result of incomplete combustion of organic materials and cigarette smoke. Epidemiological studies have consistently suggested that elderly smokers are at higher risk for small cell lung cancer (SCLC), with risks and clinical stages increasing with the intensity and duration of smoking. However, the underlying mechanism remains insufficiently investigated.

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  • PFAS are synthetic chemicals that are widely used and produced but are linked to various health issues, particularly DNA damage.
  • This study specifically examines Perfluorodecanoic acid (PFDA) and its harmful effects on DNA damage and repair in ovarian epithelial cells through animal and cell experiments.
  • Results show that PFDA exposure leads to increased DNA damage and disrupts the DNA repair process, indicating that even low doses can cause significant genomic instability.
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Background: Ensuring rapid and precise mortality prediction in patients with traumatic brain injury (TBI) at the emergency department (ED) is paramount in patient triage and enhancing their outcomes. We aimed to estimate and compare the predictive power of the Trauma Rating Index in Age, Glasgow Coma Scale, Respiratory rate, and Systolic blood pressure score (TRIAGES) and Revised Trauma Score (RTS) for 24-h in-hospital mortality in patients with isolated TBI.

Methods: We conducted a retrospective single-center study analyzing clinical data from 1156 patients with isolated acute TBI treated in the ED of the Affiliated Hospital of Nantong University from January 1, 2020, to December 31, 2020.

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To systematically evaluate the differences in therapeutic response to chemotherapy or immunotherapy between different molecular subtypes of bladder cancer (BC). A comprehensive literature search was performed up to December 2021. Consensus clusters 1 (CC1), CC2 and CC3 molecular subtypes were used to perform meta-analysis.

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Synopsis of recent research by authors named "XiaoYu Yuan"

  • - Xiaoyu Yuan's recent research encompasses a diverse range of topics, including the isolation of new triterpenoids with antibacterial properties from *Euphorbia humifusa*, which showcases the potential for discovering novel bioactive compounds in natural products.
  • - Yuan also investigates innovative therapeutic strategies for Alzheimer's disease through the use of multifunctional nanoselenium carriers to enhance drug delivery, and addresses the dual mechanisms of neuroinflammation and oxidative stress involved in neurodegeneration.
  • - Environmental health studies are another focal point, with findings on the deleterious effects of perfluoroalkyl substances (PFAS), including their role in promoting cancer progression and exacerbating intestinal inflammation, highlighting the need for further exploration of their mechanisms of toxicity.

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