Measurement of wing motion, deformation, and inertial forces of a biomimetic butterfly.

This paper introduces a method for measuring wing motion, deformation, and inertial forces in bio-inspired aircraft research using a camera motion capture system. The method involves placing markers on the wing surface and fitting rigid planes to determine the wing's spatial axis. This allows for describing the wing's rigid motion and obtaining deformation characteristics, such as deflection, twist angle, and gap distance of the forewing and hindwing.

Coupling eco-environmental quality and ecosystem services to delineate priority ecological reserves-A case study in the Yellow River Basin.

Priority ecological reserves (PER) aim to protect areas with significant ecological value and crucial ecological functions, optimizing resource allocation to maximize the benefits of ecological conservation. However, most previous studies have considered only ecosystem services (ESs) in delineating PER, neglecting eco-environmental quality (EEQ). This study used the Remote Sensing-based Ecological Index (RSEI) to represent EEQ and combined it with ESs to delineate PER at the county scale in the Yellow River Basin (YRB).

Computational Simulation Study of Potential Inhibition of c-Met Kinase Receptor by Phenoxy pyridine Derivatives: Based on QSAR, Molecular Docking, Molecular Dynamics.

The mesenchymal-epithelial transition factor (c-Met) is a tyrosine kinase receptor protein, and excessive cell transformation can lead to cancer. Therefore, there is an urgent need to develop novel receptor tyrosine kinase inhibitors by inhibiting the activity of c-Met protein. In this study, 41 compounds are selected from the reported literature, and the interactions between phenoxy pyridine derivatives and tumor-associated proteins are systematically investigated using a series of computer-assisted drug design (CADD) methods, aiming to predict potential c-Met inhibitors with high activity.

Dual-Tower Counterfactual Session-Aware Recommender System.

In the complex dynamics of modern information systems such as e-commerce and streaming services, managing uncertainty and leveraging information theory are crucial in enhancing session-aware recommender systems (SARSs). This paper presents an innovative approach to SARSs that combines static long-term and dynamic short-term preferences within a counterfactual causal framework. Our method addresses the shortcomings of current prediction models that tend to capture spurious correlations, leading to biased recommendations.

Determination of the larval precursor configuration of the Drosophila adult hindgut by G-TRACE analysis.

The Drosophila hindgut is a classical model to study organogenesis. The adult hindgut originates from the precursor cells in the larval hindgut. However, the territory of these cells has still not been well determined.

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma.

Background: Neuroendocrine neoplasms of the female genital tract are rare.

Aim: To enhance our clinical understanding of neuroendocrine carcinoma (NEC) of the ovary.

Methods: A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary, analyzing clinicopathological characteristics, treatment modalities, and survival status.

Dynamic monitoring of aboveground biomass in inner Mongolia grasslands over the past 23 Years using GEE and analysis of its driving forces.

Aboveground biomass (AGB) in grasslands directly reflects the net primary productivity, making it a sensitive indicator of grassland resource quality and ecological degradation. Accurately estimating AGB over large regions to reveal long-term AGB evolution trends remains a formidable challenge. In this study, we divided Inner Mongolia Autonomous Region (IMAR) grasslands into three study regions based on their spatial distribution of grassland types.

Transcriptomic profiling of in the neural differentiation of mouse embryonic stem cells.

Introduction: The disconnected-interacting protein 2 homolog A (DIP2A), a member of disconnected-interacting 2 protein family, has been shown to be involved in human nervous system-related mental illness. This protein is highly expressed in the nervous system of mouse. Mutation of mouse DIP2A causes defects in spine morphology and synaptic transmission, autism-like behaviors, and defective social novelty [5], [27], indicating that DIP2A is critical to the maintenance of neural development.

Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a.

Objective: Investigating the utility of serum exosomal markers CA125, HE4, and C5a, both individually and in combination, for distinguishing between benign and malignant ovarian tumors.

Methods: In this study, we selected a total of 234 patients diagnosed with ovarian tumors, including 34 with malignant tumors, 10 with borderline ovarian tumors, and 190 with benign tumors. This study conducted comparisons of exosomal levels of CA125, HE4, and C5a among distinct groups, as well as making comparisons between serum and exosomal levels of CA125 and HE4.

Study on the control effect of local basement replacement on the stability of dump.

This study focuses on effectively controlling landslides at the boundary of a soft rock open-pit dump while ensuring safe increases in the dump's capacity and optimal utilization of external dump sites. To achieve this, the adoption of a local filling method for the dump base is proposed. By leveraging the concepts of limit equilibrium theory and equivalent shear strength parameters, the mathematical expression of the slope stability coefficient in the Morgenstern-Price method is derived and improved.

Loss of Dip2b leads to abnormal neural differentiation from mESCs.

Background: Disco-interacting protein 2 homolog B is a member of the Dip2 family encoded by the Dip2b gene. Dip2b is widely expressed in neuro-related tissues and is essential in axonal outgrowth during embryogenesis.

Methods: Dip2b knockout mouse embryonic stem cell line was established by CRISPR/Cas9 gene-editing technology.

The effects of intrinsic water-use efficiency and climate on wood anatomy.

Climate warming may induce growth decline in warm-temperate areas subjected to seasonal soil moisture deficit, whereas increasing atmospheric CO concentration (C) is expected to enhance tree growth. An accurate understanding of tree growth and physiological processes responding to climate warming and increasing C is critical. Here, we analyzed tree-ring stable carbon isotope and wood anatomical traits of Pinus tabuliformis from Qinling Mountains in China to understand how lumen diameter (LD) determining potential hydraulic conductivity and cell-wall thickness (CWT) determining carbon storage responded to climate and C.

An Improved DDPG and Its Application in Spacecraft Fault Knowledge Graph.

We construct a spacecraft performance-fault relationship graph of the control system, which can help space robots locate and repair spacecraft faults quickly. In order to improve the performance-fault relationship graph, we improve the Deep Deterministic Policy Gradient (DDPG) algorithm, and propose a relationship prediction method that combines representation learning reasoning with deep reinforcement learning reasoning. We take the spacecraft performance-fault relationship graph as the agent learning environment and adopt reinforcement learning to realize the optimal interaction between the agent and the environment.

Comparison of laparoscope-assisted single-needle laparoscopic percutaneous extraperitoneal closure versus open repair for pediatric inguinal hernia.

Background: Laparoscopic-assisted repairs for pediatric inguinal hernia have gained gradual acceptance over the past decade. However, consensus about the optimal management is still lacking. The aim of this study is to compare outcomes of a modified laparoscope-assisted single-needle laparoscopic percutaneous extraperitoneal closure (LPEC) versus open repair of pediatric hernias/hydrocele in a single institution.

Dynamic of land use, landscape, and their impact on ecological quality in the northern sand-prevention belt of China.

Changes in land use and landscapes have a direct impact on the regional eco-environment. It is of great importance to understand the change pattern of land use, landscapes, and their mechanism on the ecological quality, especially ecologically fragile areas. The northern sand-prevention belt (NSPB) is an important ecologically fragile area in China, which has a large influence on the ecological security of the entire country.

Ability of volume measures of hydronephrosis to predict need for surgery and evaluate renal function in children with ureteropelvic junction obstruction.

Objective: To explore the efficacy of quantitative renal volume measures on magnetic resonance urography images in predicting need for surgery among children with ureteropelvic junction obstruction and their ability to evaluate renal function.

Methods: A total of 88 cases of hydronephrosis in 50 patients were collected between 1 April 2018 and 31 March 2020, including 30 operated kidney and 58 unoperated kidney cases. Clinical data were collected, and quantitative analysis of magnetic resonance urography was performed.

Comparative Minimal Inhibitory and Mutant Prevention Concentration of Eight Antimicrobial Agents Against .

With the emergence of multidrug-resistant and pan-resistant strains, () shows higher treatment failure rates and mortality in clinics. It is more important to develop an effective method for treating infections. The main objectives of this study were to determine the minimal inhibitory concentration (MIC) and the mutant prevention concentration (MPC) for eight antimicrobial agents against isolated from different hosts and compare the emergence of resistant mutants between animal strains and human strains.

Knockout of Dip2c in murine ES cell line IBMSe001-B-1 by CRISPR/Cas9 genome editing technology.

DIP2 protein contains three members: DIP2A, DIP2B and DIP2C, and are broadly expressed in the nervous system from Drosophila to human during embryonic development. Dip2c gene-associated mutations have been reported in tumors and neuronal diseases. However, the role ofDip2cin the context of mouse embryonic stem (mES) cells has not been explored.

Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study.

Neuropeptide FF (NPFF) is a neuropeptide that modulates various physiological processes. The regulatory role of NPFF in the immune and inflammatory response is currently being revealed. However, the effect of NPFF at the transcriptome level in macrophages has not been fully elucidated.

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells.

Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1% of men, are currently limited by the incomplete understanding of NOA pathogenesis and normal spermatogenic microenvironment. Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. We show that Sertoli cells, which form the scaffold in the testicular microenvironment, are severely damaged in NOA patients and identify the roadmap of Sertoli cell maturation.

Matrix Remodeling-Associated Protein 5 in Urinary Exosomes as a Potential Novel Marker of Obstructive Nephropathy in Children With Ureteropelvic Junction Obstruction.

Recent investigations have described the use of urinary matrix remodeling-associated protein 5 (MXRA5) as a novel biomarker of kidney impairment in the setting of chronic kidney disease. In this study, we aimed to evaluate the possible clinical application of urinary MXRA5 as a useful non-invasive marker in the urine from the affected renal pelvis and bladder of children with ureteropelvic junction obstruction (UPJO). We conducted a prospective cohort study of patients aged <12 months with prenatally diagnosed unilateral UPJO who underwent dismembered pyeloplasty in 2018 or 2019, and a sex- and age-matched control group of healthy children.

Leydig-like cells derived from reprogrammed human foreskin fibroblasts by CRISPR/dCas9 increase the level of serum testosterone in castrated male rats.

In the past few years, Leydig cell (LC) transplantation has been regarded as an effective strategy for providing physiological patterns of testosterone in vivo. Recently, we have successfully converted human foreskin fibroblasts (HFFs) into functional Leydig-like cells (iLCs) in vitro by using the CRISPR/dCas9 system, which shows promising potential for seed cells. However, it is not known whether the reprogrammed iLCs can survive or restore serum testosterone levels in vivo.