Overexpression of Heme Oxygenase 1 Enhances the Neuroprotective Effects of Exosomes in Subarachnoid Hemorrhage by Suppressing Oxidative Stress and Endoplasmic Reticulum Stress.

Aims: This study aims to elucidate the therapeutic effects and underlying mechanisms of exosomes derived from Heme oxygenase 1 (HO-1)-overexpressing human umbilical cord mesenchymal stem cells (Exo) in a subarachnoid hemorrhage (SAH) mouse model.

Methods: In this study, exosomes were identified using Western blotting, particle analysis, and transmission electron microscopy. The effect of Exo and Exo on the neurological function of SAH mice was assessed using the Garcia scoring system, Beam balance, Rotarod test, and Morris water maze test.

Comparative study of Claude 3.5-Sonnet and human physicians in generating discharge summaries for patients with renal insufficiency: assessment of efficiency, accuracy, and quality.

Background: The rapid development of artificial intelligence (AI) has shown great potential in medical document generation. This study aims to evaluate the performance of Claude 3.5-Sonnet, an advanced AI model, in generating discharge summaries for patients with renal insufficiency, compared to human physicians.

A phase 2 pilot study of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) is an aging-related malignancy, with patients aged ≥60 years old facing significantly poorer prognosis. Umbilical cord blood (UCB) has emerged as a promising source with effective anti-aging roles. Here, we conducted a prospective, phase 2, single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients (ChiCTR-OPC-15006492).

Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism.

Accurately assessing potential side effects following botulinum neurotoxin (BoNT) injection remains a formidable challenge. To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophisticated volatilomics technique, aimed at facilitating the rapid and convenient prediction of potential physical discomfort related to latrogenic botulism. The investigation identifies five volatile organic compounds (VOCs)-acetone, styrene, ethanol, 2-pentanone, and n-butano-as promising markers indicative of BoNT poisoning.

Banana Starch Nanoparticles Disrupt the Integrity of the Intestinal Barrier by Opening Tight Junctions in Mice.

The banana-derived starch nanoparticles have been extensively used in food and biomedicine industries, due to their unique physicochemical properties and functional benefits. With their pervasive presence in food, people are significantly exposed to these nanoparticles, raising concerns about their potential health risks and impact on intestinal health. However, there is still limited understanding of the direct interaction between native banana starch nanoparticles (BSNs) and the intestinal systems.

Factors influencing the self-management ability among older adults experiencing intrinsic capacity decline: a cross-sectional study.

Aims: This study investigated the current status of intrinsic capacity and self-management abilities and analyzed the factors influencing the self-management abilities of older adults experiencing intrinsic capacity decline.

Methods: We included a sample of 382 older adults, with an average age of 72.92 ± 6.

Fluoroquinolone antibiotics trigger selective oxidation in the trace-Cu(II)/peroxydisulfate system: The synergistic effect of dual reactive sites in chemical structure.

Research on transition metal-triggered advanced oxidation processes (TM-AOPs) has primarily focused on the regulation of catalysts and oxidants, but the alternative route that involves utilizing pollutant-derived electrons to enhance TM-AOPs has been largely overlooked. This study presents a case of selective degradation using fluoroquinolone antibiotics, with ofloxacin (OFX) selected as the model pollutant. Under the presence of PDS and trace Cu(II) (10 μM or 0.

iGTP: Learning interpretable cellular embedding for inferring biological mechanisms underlying single-cell transcriptomics.

Deep-learning models like Variational AutoEncoder have enabled low dimensional cellular embedding representation for large-scale single-cell transcriptomes and shown great flexibility in downstream tasks. However, biologically meaningful latent space is usually missing if no specific structure is designed. Here, we engineered a novel interpretable generative transcriptional program (iGTP) framework that could model the importance of transcriptional program (TP) space and protein-protein interactions (PPI) between different biological states.

Harnessing machine learning and multi-omics to explore tumor evolutionary characteristics and the role of AMOTL1 in prostate cancer.

Although recent advancements have shed light on the crucial role of coordinated evolution among cell subpopulations in influencing disease progression, the full potential of these insights has not yet been fully harnessed in the clinical application of personalized precision medicine for prostate cancer (PCa). In this study, we utilized single-cell sequencing to identify the evolutionary characteristics of tumoral cell states and employed comprehensive bulk RNA sequencing to evaluate their potential as prognostic indicators and therapeutic targets. Leveraging advancements in artificial intelligence, we integrated machine learning with multi-omics to develop and validate the tumor evolutionary characteristic predictive indicator (TECPI).

Revealing the Overlooked Catalytic Ability of γ-AlO: Efficient Activation of Peroxymonosulfate for Enhanced Water Treatment.

Activated alumina (γ-AlO) is one of the few nanomaterials manufactured at a ton-scale and successfully implemented in large-scale water treatment. Yet its role in advanced oxidation processes (AOPs) has primarily been limited to functioning as an inert carrier due to its inherently nonredox nature. This study, for the first time, presents the highly efficient capability of γ-AlO to activate peroxymonosulfate (PMS) for selectively eliminating electron-rich organic pollutants in the presence of Cl.

Comparative Study on the Prevention and Control Effects of Rockburst Between Hydraulic Fracturing Sections and Blank Sections.

Influenced by various factors such as the complex environment and high key layers in coal mines, hydraulic fracturing technology has gradually become the main means of controlling the hard roof strata to prevent and control rockburst in recent years, which can effectively release the stress on the roof, reduce the intensity of pressure, and ensure the safe and efficient mining of the working face in coal mines. However, the current research on hydraulic fracturing to prevent and control rockburst is mostly limited to optimizing fracturing parameters and monitoring and evaluating fracturing effects, and there are few studies on blank sections, which cannot guarantee the overall prevention and control effect of rockburst, or increase unnecessary construction costs. In this paper, for the directional long borehole staged hydraulic fracturing project, triangular-type blank sections and regular-type blank sections are defined, and the rockburst prevention and control effects of fracturing sections and triangular-type blank sections during fracturing are compared and analyzed by the underground-ground integrated microseismic monitoring technology and transient electromagnetic detection technology, and the rockburst prevention and control effects of fracturing sections and regular-type blank sections during the coal extraction period are compared and analyzed by the underground-ground integrated microseismic monitoring data such as microseismic energy level and frequency as well as the online stress monitoring data.

Unexpected chloride-triggered organics removal in the zirconium oxide activated peroxymonosulfate system.

Chloride ion (Cl) is ubiquitous in diverse water bodies, yet poses a longstanding challenge in water pollution control by hindering the efficiency of pollutant degradation. Herein, we proposed a novel concept involving the direct utilization of endogenous Cl ions in water for rapid water purification within a non-redox zirconium oxide (ZrO)-activated peroxymonosulfate (PMS) system. In this process, PMS was complexed on the ZrO surface through inner-sphere coordination, and effectively activated by the partial electron cloud deviation from Zr(IV) sites to PMS, thereby forming a metastable surface complex with an elevated redox potential.

Effect of therapeutic erythrocytapheresis on outcomes and renal benefit in patients with high-altitude polycythemia: a real-world study.

Kidney injury from high-altitude polycythemia (HAPC) is common, yet few studies have explored effective treatments. This research assessed the renal benefits of therapeutic erythrocytapheresis (TE) in HAPC patients, analyzing the efficacy of single versus multiple treatments. From 2017 to 2023, 631 patients undergoing TE were included.

InGaSn-assisted in-fiber Fabry-Perot temperature sensor with ultra-high sensitivity.

In this paper, we proposed an in-fiber Fabry-Perot temperature sensor which filled with Indium gallium stannum (InGaSn) alloy. By splicing a single-mode fiber axially with hollow-core fibers (HCFs) of varying inner diameters, a cavity of the Fabry-Perot interferometer (FPI) structure is formed. Assisted by liquid metal with fluidity and high thermal expansivity, subtle temperature fluctuations are converted into variations in the interferometric cavity length which leads to a significant spectral drift.

Enhancing nutritional management in peritoneal dialysis patients through a generative pre-trained transformers-based recipe generation tool: a pilot study.

Background: Patients undergoing peritoneal dialysis (PD) often face nutritional deficiencies due to inadequate intake, nutrient loss, insufficient dialysis, and a state of micro-inflammatory. Traditional nutritional management methods have not fully met personalized needs. Therefore, this study aimed to develop and evaluate an application for generating recipes based on Generative Pre-trained Transformers to improve the nutritional status of these patients.

Simulation Study on Reservoir Stimulation of Multihorizontal Wells for Gas Hydrate Production in Low-Permeability Reservoirs.

The feasibility of hydrate exploitation technology has been verified by two rounds of trial productions in the South China Sea, but it is also faced with the problem of low gas production efficiency. Therefore, this paper proposed four different hydrate production cases with multihorizontal wells and established simulation models. Then, the influence patterns of reservoir stimulation and offset distances on hydrate dissociation, saturation change, and pressure distribution were studied.

Triple-Branch Catalytic Assembly DNAzyme Motivated DNA Tweezer for Sensitive and Reliable mecA Gene Detection in .

( SA) is one of the most common bacteria in nosocomial infections. Sensitive and efficient analysis of methicillin-resistance of SA is crucial for improving the nursing performance of pneumonia. However, methicillin-resistance analysis with favorable sensitivity and specificity in an enzyme-free manner remains a huge challenge.

Multivalent bifunctional nanobody to enhance the sensitivity of direct competitive chemiluminescence immunoassay for the detection of microcystin LR in lake water.

Microcystin-LR (MC-LR), a toxic cyanobacterial toxin in freshwater, poses significant health and ecological risks due to its ability to induce cell apoptosis and liver damage. Sensitive detection of MC-LR is crucial for public health and water safety. In this work, we engineered a multivalent bifunctional nanobody (A2.

Resistant Starch Nanoparticles Induce Colitis through Lysosomal Exocytosis in Mice.

Resistant starch (RS) is present in various natural and processed foods as well as medications. It has garnered significant attention from both scientists and consumers due to its notable health benefits. However, there is a limited understanding of how RS particles are absorbed at the cellular level and their metabolic behavior, resulting in a lack of clarity regarding the intestinal safety implications of prolonged RS exposure.

Association of Spouses' Sensory Loss with Depressive Symptoms, Self-Reported Health, and Functional Disability Among Middle-Aged and Older Adults in China: A Cross-Sectional Study.

Objective: To investigate cross-sectional associations between spouses' sensory loss and depressive symptoms, self-rated health, and functional disability.

Methods: We included 10,410 individuals from the China Health and Retirement Longitudinal Study. We used the cross-sectional design and determined hearing loss, vision loss, and dual sensory loss by self-reports.