Proactive risk assessment of intrahospital transport of critically ill patients from emergency department to intensive care unit in a teaching hospital and its implications.

Aims And Objectives: To explore the effects of the health failure mode and effect analysis (HFMEA) used in intrahospital transport (IHT) of critically ill patients from emergency department (ED) to the intensive care unit (ICU).

Background: Patients who were transported from ED to ICU is highly critical. IHT of these patients is potentially risky, which may associate with adverse events (AEs).

Degradation of saccharin by UV/HO and UV/PS processes: A comparative study.

Artificial sweeteners have raised emerging concern due to their potential threats to human health, which were frequently detected in aquatic environment with median concentrations. Although current researches have widely reported that ultraviolet light-activated persulfate process (UV/PS) was superior to UV/HO process for the degradation of refractory organic contaminants, UV/HO process presented a more satisfactory saccharin (SAC) removal efficiency than UV/PS process, completely degraded 20 mg/L SAC within 45 min. Hence, quenching and probe experiments were employed to investigate the difference between hydroxyl radical (OH)- and sulfate radical (SO)-mediated oxidation mechanisms, which revealed the higher reactivity of OH (1.

Prevalence and related factors of hyperuricaemia in Shanghai adult women of different ages: a multicentre and cross-sectional study.

Objective: Women in different age phases have different metabolism and hormone levels that influence the production and excretion of uric acid. We aimed to investigate the prevalence and related factors of hyperuricaemia among women in various age phases.

Study Design: Observational, cross-sectional study.

Requirement of Histone Deacetylase 6 for Interleukin-6 Induced Epithelial-Mesenchymal Transition, Proliferation, and Migration of Peritoneal Mesothelial Cells.

Influenced by microenvironment, human peritoneal mesothelial cells (HPMCs) acquired fibrotic phenotype, which was identified as the protagonist for peritoneal fibrosis. In this study, we examined the role of histone deacetylase 6 (HDAC6) for interleukin-6 (IL-6) induced epithelial-mesenchymal transition (EMT), proliferation, and migration of HPMCs. The role of HDAC6 in IL-6-elicited EMT of HPMCs was tested by morphological observation of light microscope, immunoblotting, and immune-fluorescence assay; and the function of HDAC6 in proliferation and migration of HPMCs was examined by CCK-8 assay, wound healing experiment, and immunoblotting.

Spatio-temporal variability of halogenated disinfection by-products in a large-scale two-source water distribution system with enhanced chlorination.

Distributions of halogenated disinfection byproducts (DBPs) in a two-source water distribution system (WDS) with enhanced chlorination were investigated. The WDS was divided into different sub-service areas based on different electrical conductivity of two water sources. Results clearly show that the principal halogenated DBPs were trihalomethanes (THMs) (5.

Blockade of Autophagy Prevents the Development and Progression of Peritoneal Fibrosis.

Peritoneal fibrosis (PF) is a major cause of ultrafiltration failure in long-term peritoneal dialysis (PD) patients. Nevertheless, limited measures have been shown to be effective for the prevention and treatment of PF. Some views reveal that activation of autophagy ameliorates PF but others demonstrate that autophagy promotes PF.

Clozapine induces metformin-resistant prediabetes/diabetes that is associated with poor clinical efficacy in patients with early treatment-resistant schizophrenia.

Background: Two distinct subtypes of treatment-resistant schizophrenia (TRS) have been recently reported, including early-treatment resistance (E-TR) and late-treatment resistance (L-TR). This study was to assess clozapine-induced metformin-resistant prediabetes/diabetes and its correlation with clinical efficacy in schizophrenia E-TR subtype.

Methods: This prospective cohort study enrolled 230 patients with schizophrenia E-TR subtype and they were treated with adequate doses of clozapine for 16 weeks, during which patients with prediabetes/diabetes were assigned to receive add-on metformin.

Combined Transcriptomic Analysis and RNA Interference Reveal the Effects of Methoxyfenozide on Ecdysone Signaling Pathway of .

is a worldwide pest afflicting edible vegetables and has developed varying levels of resistance to insecticides. Methoxyfenozide (MET), an ecdysteroid agonist, is effective against lepidopteran pests such as . However, the mechanism of MET to remains unclear.

Prefrontal inhibition drives formation and dynamic expression of probabilistic Pavlovian fear conditioning.

The association between cause and effect is usually probabilistic. Memories triggered by ambiguous cues may be altered or biased into a more negative perception in psychiatric diseases. Understanding the formation and modulation of this probabilistic association is important for revealing the nature of aversive memory and alterations in brain diseases.

Exploring dust heterogeneous chemistry over China: Insights from field observation and GEOS-Chem simulation.

Dust heterogeneous chemistry plays an important role in tropospheric chemistry, but its parameterization in numerical models is often quite simplified, which hampers accurate prediction of particulate matter and its chemical component. In this study, we investigate the evolution of dust heterogeneous chemical process and its potential impacts on gaseous and aerosol components during a dust pollution episode from March 27 to April 2, 2015 over North China. Based on field measurements, the significant role of relative humidity (RH) in dust heterogeneous chemistry is found and a RH-dependent parameterization for uptake coefficients of HNO and SO is incorporated in GEOS-Chem to reproduce the dust heterogeneous chemical process.

The trans-omics landscape of COVID-19.

The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill.

The prognosis and risk factors of baseline high peritoneal transporters on patients with peritoneal dialysis.

The relationship between baseline high peritoneal solute transport rate (PSTR) and the prognosis of peritoneal dialysis (PD) patients remains unclear. The present study combined clinical data and basic experiments to investigate the impact of baseline PSTR and the underlying molecular mechanisms. A total of 204 incident CAPD patients from four PD centres in Shanghai between 1 January 2014 and 30 September 2020 were grouped based on a peritoneal equilibration test after the first month of dialysis.

Efficient and stable inverted perovskite solar cells with very high fill factors via incorporation of star-shaped polymer.

Stabilizing high-efficiency perovskite solar cells (PSCs) at operating conditions remains an unresolved issue hampering its large-scale commercial deployment. Here, we report a star-shaped polymer to improve charge transport and inhibit ion migration at the perovskite interface. The incorporation of multiple chemical anchor sites in the star-shaped polymer branches strongly controls the crystallization of perovskite film with lower trap density and higher carrier mobility and thus inhibits the nonradiative recombination and reduces the charge-transport loss.

The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury.

Acute kidney injury (AKI) is a common clinical complication with an incidence of up to 8-18% in hospitalized patients. AKI is also a complication of COVID-19 patients and is associated with an increased risk of death. In recent years, numerous studies have suggested that epigenetic regulation is critically involved in the pathophysiological process and prognosis of AKI.

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.

In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However, neither parent-of-origin-specific transcription nor imprints have been comprehensively mapped at the blastocyst stage of preimplantation development. Here, we address this by integrating transcriptomic and epigenomic approaches in mouse preimplantation embryos.

Significant underestimation of radiative forcing by aerosol-cloud interactions derived from satellite-based methods.

Satellite-based estimates of radiative forcing by aerosol-cloud interactions (RF) are consistently smaller than those from global models, hampering accurate projections of future climate change. Here we show that the discrepancy can be substantially reduced by correcting sampling biases induced by inherent limitations of satellite measurements, which tend to artificially discard the clouds with high cloud fraction. Those missed clouds exert a stronger cooling effect, and are more sensitive to aerosol perturbations.

Micropollutants and biological effects as control indexes for the operation and design of shallow open-water unit ponds to polish domestic effluent.

Additional control indexes should be considered for the operation and design of post-treatment systems, as the wastewater treatment objectives are developing toward protecting the safety of ecological environments. In this study, two control indexes were selected and examined systematically in pilot-scale shallow open-water unit (SOWU) ponds for domestic effluent polishing: micropollutants and biotoxicities. The total risk quotient (RQ ≤ 1) and effect-based trigger value (EBT) were set as the thresholds for known micropollutants and biological effects, respectively.

[Microbial green manufacturing of higher alcohols].

Higher alcohols that contain more than two carbon atoms have better fuel properties than ethanol, making them important supplements and alternatives to fossil fuels. Using microbes to produce higher alcohols from renewable biomass can alleviate the current energy and environmental crises, and has become a major future direction for green biomanufacturing. Since natural microbes can only produce a few higher alcohols in small amounts, it is necessary to reconstruct the synthetic pathways for higher alcohols in model industrial strains through metabolic engineering and synthetic biology to overcome the metabolic bottlenecks.

Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.

Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of aberrant plasma cells within the bone marrow. The high frequent mutation of family with sequence similarity 46, member C (FAM46C) is closely related with the occurrence and progression of MM. Recently, FAM46C has been identified as a non-canonical poly(A) polymerase (PAP) that functions as a tumor suppressor in MM.

A feasible electrochemical biosensor for determination of glucose based on Prussian blue - Enzyme aggregates cascade catalytic system.

The coral-like gold micro/nanostructures were formed onto carbon cloth followed by a Prussian blue (PB) electrochemical deposition to construct a highly sensitive HO biosensor. The SEM image of PB/Au/CC showed the coral-like gold morphology, and EDS and XPS tests also further confirmed the successful loading of Au and PB. The electrochemical tests of PB/Au/CC displayed the electrode possessed excellent performance in sensing HO, which was quantified in the linear range from 0.

Transcriptome analysis reveals the promotive effect of potassium by hormones and sugar signaling pathways during adventitious roots formation in the apple rootstock.

Apples are economically valuable and widely consumed fruits. The adventitious roots (ARs) formation is gridlock for apple trees mass propagation. The possible function of multiple hormones and sugar signaling pathways regulating ARs formation has not been completely understood in apple.

Clinical outcomes, quality of life, and costs evaluation of peritoneal dialysis management models in Shanghai Songjiang District: a multi-center and prospective cohort study.

The new Family-Community-Hospital (FCH) three-level comprehensive management aimed to improve the efficiency and scale of peritoneal dialysis (PD) to meet the increased population of end-stage renal disease (ESRD). Our study focused on the clinical outcomes, quality of life, and costs evaluation of this model in a multi-center and prospective cohort study. A total of 190 ESRD patients who commenced PD at Shanghai Songjiang District were enrolled.