Association between healthy lifestyle on life course and multimorbidity in adults: results from two national prospective cohort studies.

Objectives: To examine the correlation between healthy lifestyle patterns, their change trajectories, and the risk of multimorbidity in adults.

Methods: Based on two representative national cohorts, the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) including adults aged 50 years and over. We employed Cox regression, lifestyle change trajectories, and restricted mean survival times to explore the relationship between lifestyle (assessed by SCORE2, LE'8, and HLS scores) and multimorbidity.

Associations of air pollutants and related metabolites with preterm birth during pregnancy.

Objective: This study aimed to investigate the influence of exposure to ambient fine particulate matter (PM) and its components during pregnancy on the prevalence of preterm birth (PTB). Additionally, we sought to identify the susceptible exposure window. Furthermore, we explored the potential mediating role of blood analysis and a comprehensive metabolic panel in the association between pollutant exposure and PTB incidence.

Effects of diets on risks of cancer and the mediating role of metabolites.

Research on the association between dietary adherence and cancer risk is limited, particularly concerning overall cancer risk and its underlying mechanisms. Using the UK Biobank data, we prospectively investigate the associations between adherence to a Mediterranean diet (MedDiet) or a Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay diet (MINDDiet) and the risk of overall and 22 specific cancers, as well as the mediating effects of metabolites. Here we show significant negative associations of MedDiet and MINDDiet adherence with overall cancer risk.

Long-Term Exposure to Fine Particulate Matter and Fasting Blood Glucose and Diabetes in 20 Million Chinese Women of Reproductive Age.

Objective: Evidence of the associations between fine particulate matter (PM2.5) and diabetes risk from women of reproductive age, in whom diabetes may have adverse long-term health effects for both themselves and future generations, remains scarce. We therefore examined the associations of long-term PM2.

Association between plasma metal exposure and health span in very elderly adults: a prospective cohort study with mixture statistical approach.

Background: Metals have been linked to a diverse spectrum of age-related diseases; however, the effects of metal exposure on health span remains largely unknown. This cohort study aims to determine the association between plasma metal and health span in elder adults aged ≥ 90 years.

Methods: The plasma concentrations of seven metals were measured at baseline in 300 elder adults.

Association and mediation between educational attainment and respiratory diseases: a Mendelian randomization study.

Background: Respiratory diseases are a major health burden, and educational inequalities may influence disease prevalence. We aim to evaluate the causal link between educational attainment and respiratory disease, and to determine the mediating influence of several known modifiable risk factors.

Methods: We conducted a two-step, two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide association studies (GWAS) and single nucleotide polymorphisms (SNPs) as instrumental variables for educational attainment and respiratory diseases.

Metabolomic landscape of overall and common cancers in the UK Biobank: A prospective cohort study.

Information about the NMR metabolomics landscape of overall, and common cancers is still limited. Based on a cohort of 83,290 participants from the UK Biobank, we used multivariate Cox regression to assess the associations between each of the 168 metabolites with the risks of overall cancer and 20 specific types of cancer. Then, we applied LASSO to identify important metabolites for overall cancer risk and obtained their associations using multivariate cox regression.

Association between longitudinal dietary patterns and changes in obesity: a population-based cohort study.

Introduction: Research on the trajectory of dietary patterns and changes in obesity has been inconclusive.

Methods: This study described the dietary intake and adiposity trajectories of Chinese adults and assessed the association between dietary trajectories and changes in body mass index (BMI) and waist-to-hip ratio (WHR). We used data from 3, 643 adults who participated in the China Health and Nutrition Survey from 1997 to 2015.

Association of ambient PM and PM with coronary stenosis measured using selective coronary angiography.

Background: Long-term ambient particulate matter (PM) exposure exerts detrimental effects on cardiovascular health. Evidence on the relation of chronically exposed ambient PM and PM with coronary stenosis remains lacking. Our aim was to investigate the association of PM and PM with coronary stenosis in patients undergoing coronary angiography.

Hyperuricemia and coronary heart disease: The mediating role of blood pressure and thrombospondin 3.

Background & Aims: Although hyperuricemia is a known risk factor for coronary heart disease (CHD), little is known about the role of blood pressure in mediating this association. The purpose of this study is to investigate the role of blood pressure-related indicators and Thrombospondin 3 (THBS3) in the association between hyperuricemia and CHD.

Methods And Results: Our observational epidemiology study included 593 CHD cases and 760 controls from a residential stable sample.

Association of longitudinal patterns of nighttime sleep duration and daytime napping duration with risk of multimorbidity.

Objectives: To determine whether longitudinal trajectories of nighttime sleep duration and daytime napping duration are related to subsequent multimorbidity risk. To explore whether daytime napping can compensate for negative effects of short nighttime sleep.

Methods: The current study included 5262 participants from China Health and Retirement Longitudinal Study.

Association between polyfluoroalkyl substances exposure and sex steroids in adolescents: The mediating role of serum albumin.

Background: Polyfluoroalkyl substances (PFASs) are an emerging class of contaminants with endocrine disrupting hazards. The impact of PFASs exposure on sex steroids remain inconclusive.

Methods: This study used data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES), including 525 adolescents aged 12-19.

Association between solid cooking fuel and cognitive decline: Three nationwide cohort studies in middle-aged and older population.

Background: Household solid-fuel burning contributes to indoor air pollution and is linked to poor cognitive function, but how solid cooking fuel use leads to cognitive decline over time is not well elaborated.

Objective: We examine the associations of solid cooking fuel with cognitive function among three nationally representative cohorts.

Methods: This study uses data from the 2010-2018 China Family Panel Studies (CFPS), the 2011-2018 China Health and Retirement Longitudinal Study (CHARLS) and the 2003-2015 Mexican Health and Aging Study (MHAS) in adults over the age of 50.

Physical Changes of Preschool Children during COVID-19 School Closures in Fujian, China.

The COVID-19 pandemic may constitute an "obesogenic lifestyle" that results in exacerbating childhood obesity. However, studies investigating regional sociodemographic factors including different age groups or sexes in children with obesity are lacking. We aimed to clarify the high obesity prevalence populations of preschool children to provide a regional basis for children's health policy during the COVID-19 school closures.

Association of greenness exposure with coronary artery stenosis and biomarkers of myocardial injury in patients with myocardial infarction.

Background: Greenness has been linked to cardiovascular health; however, limited evidence is available regarding its association with coronary artery stenosis and biomarkers of myocardial injury. We aimed to assess these associations and examine their modification and mediation effects in patients with myocardial infarction (MI).

Methods: This study included 2030 patients with MI.

Effects of Weak Bedding Plane, Fault, and Extreme Rainfall on the Landslide Event of a High Cut-Slope.

High cut-slopes are widespread in engineering constructions and often converted into landslides. Some extreme circumstances facilitate the landslide process, such as the weak bedding plane, rainfall, and faults. Therefore, this paper intends to offer insights into the influence of the weak bedding plane, extreme rainfall as well as faults on the landslide process of the high cut-slope.

Association between fine particulate matter and coronary heart disease: A miRNA microarray analysis.

Several studies have reported an association between residential surrounding particulate matter with an aerodynamic diameter ≤2.5 μm (PM) and coronary heart disease (CHD). However, the underlying biological mechanism remains unclear.

The spatiotemporal correlation of PM concentration on esophageal cancer hospitalization rate in Fujian province of China.

This paper aimed to explore the correlation between PM concentration and hospitalization rate of esophageal cancer in Fujian province, and tried to find out the accurate lag effect between PM and hospitalization rate in 70 counties from the linear and nonlinear aspects. We extracted inpatients data of esophageal cancer from the New Rural Cooperative Medical Scheme (NRCMS) database and air pollutant PM grid data published by the atmospheric composition analysis group. The study showed that the hospitalization rate of esophageal cancer presented spatial aggregation in 70 counties of Fujian province.

Effect of apparent temperature on hospitalization from a spectrum of cardiovascular diseases in rural residents in Fujian, China.

Cardiovascular disease (CVD) is a leading threat to global public health. Although associations between temperature and CVD hospitalization have been suggested for developed countries, limited evidence is available for developing countries or rural residents. Moreover, the effect of apparent temperature (AT) on the spectrum of cause-specific CVDs remains unknown.

Data Mining and Deep Learning for Predicting the Displacement of "Step-like" Landslides.

Landslide displacement prediction is one of the unsolved challenges in the field of geological hazards, especially in reservoir areas. Affected by rainfall and cyclic fluctuations in reservoir water levels, a large number of landslide disasters have developed in the Three Gorges Reservoir Area. In this article, the Baishuihe landslide was taken as the research object.

Association between greenness and dyslipidemia in patients with coronary heart disease: A proteomic approach.

Background: Residential surrounding greenness may be protective of dyslipidemia are often theorized but remain poorly quantified. In particular, the underlying biological mechanisms of blood lipid changes with green spaces remain unclear.

Methods: Our observational epidemiology study included a residentially stable sample of 1035 coronary heart disease patients, and proteomics study included 16 participants.