Publications by authors named "XiaoWen Fang"

Objective: To investigate contralateral central lymph node metastasis (CCLNM) in patients with unilateral papillary thyroid carcinoma (UPTC). To provide a reference for clinical decision-making, a prediction model for the probability of CCLNM was established.

Method: The clinicopathological data of 221 UPTC patients who underwent surgical treatment were retrospectively analyzed.

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The traditional surgical methods to the fracture of the inferior patellar fracture include steel wire tension band fixation and inferior patellar resection, which have many disadvantages. In order to overcome the disadvantages of traditional surgery, we innovated and improved the double row anchor suture bridge technology to the treat the inferior patellar fracture. This study is to investigate the method, technique and clinical efficacy of double-row anchor suture bridge technique in the treatment of inferior pole fractures of patella.

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Purpose: To explore the effect of oral tranexamic acid treatment on the blood transfusion rate and the incidence of deep vein thromboembolism after total knee arthroplasty (TKA).

Methods: 90 patients undergoing TKA admitted to First People's Hospital of Changshu City from January 2019 to January 2020 were selected and randomized into the control group and the experimental group accordingly (45 cases in each group). The control group intravenously received 20 mL/kg tranexamic acid before the incision was closed.

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Recently, movie-watching fMRI has been recognized as a novel method to explore brain working patterns. Previous researchers correlated natural stimuli with brain responses to explore brain functional specialization by "reverse correlation" methods, which were based on within-group analysis. However, what external stimuli drove significantly different brain responses in two groups of different subjects were still unknown.

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Objective: To compare the clinical outcome and postoperative complications of the treatment of supination-external rotation-type ankle fractures using the posterolateral approach in the prone position and the lateral approach in the supine position.

Methods: A retrospective cohort study was conducted in our hospital, including a total of 66 patients ranging from January 2013 to February 2016, regardless of age or sex. All the patients were classified as Lauge-Hansen supination-external rotation (SER)-type ankle fractures and were assigned to receive an open reduction and internal fixation (ORIF) through a posterolateral approach performed in the prone position (the "posterolateral approach group," 32 patients), or a lateral approach performed in the supine position (the "Lateral Approach Group," 34 patients).

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Background: The protein energy landscape underscores the inherent nature of proteins as dynamic molecules interconverting between structures with varying energies. Reconstructing a protein's energy landscape holds the key to characterizing a protein's equilibrium conformational dynamics and its relationship to function. Many pathogenic mutations in protein sequences alter the equilibrium dynamics that regulates molecular interactions and thus protein function.

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Background: The traditional posterior lumbar interbody fusion (PLIF) technique usually involves implantation of two cages through a bilateral approach and bilateral laminectomy, which requires bilateral transpedicle screw fixation. The procedure itself has several negative impacts. Therefore, a modified PLIF procedure that includes insertion of a unilateral cage through the symptomatic side with supplementary unilateral pedicle screws has been conducted.

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A novel bioelectrochemical system (BES) was designed to recover copper and nickel from wastewater sequentially. The BES has two chambers separated by a bipolar membrane and two cathodes. Firstly, the copper ions were reduced on a graphite cathode with electricity output, and then with an additional bias-potential applied, the nickel ions were recovered sequentially on a copper sheet with electricity input.

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Two robust combinations of spectral editing techniques with 2D (13)C-(13)C NMR have been developed for characterizing the aromatic components of (13)C-enriched low-temperature carbon materials. One method (exchange with protonated and nonprotonated spectral editing, EXPANSE) selects cross peaks of protonated and nearby nonprotonated carbons, while the other technique, dipolar-dephased double-quantum/single-quantum (DQ/SQ) NMR, selects signals of bonded nonprotonated carbons. Both spectra are free of a diagonal ridge, which has many advantages: Cross peaks on the diagonal or of small intensity can be detected, and residual spinning sidebands or truncation artifacts associated with the diagonal ridge are avoided.

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A nitrogen-rich segment in a fulvic acid (FA) from Pony Lake, a coastal pond in Antarctica, was investigated by (15)N and (13)C{(14)N} solid-state NMR techniques. As reported previously, the (13)C{(14)N} spectrum of C bonded to N exhibits a peak at 157 ppm that is assigned to an sp(2)-hybridized carbon bonded to at least two nitrogen atoms. This segment contains 48% of all N in the sample.

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The high molecular weight fraction of melanoidins formed in the Maillard reaction between isotopically labeled glucose and glycine has been characterized comprehensively using advanced (13)C and (15)N solid-state NMR with spectral editing. We have focused on the fate of glucose in a 1:1 molar ratio with glycine, heated as a coprecipitated powder at 125 °C for 2 h. Quantitative (13)C NMR spectra show that aromatic and alkene carbons make up only 40% of the total in the melanoidin.

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Objective: This study was designed to evaluate the clinical and pathological characteristics of adrenal masses.

Methods: The clinical data of 249 cases of adrenal masses which were confirmed at operation and by pathology were analyzed.

Results: The series comprised 103 males and 146 females.

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The fate of the amino acid in the model Maillard reaction between glucose and glycine in a 1:1 molar ratio has been investigated by applying advanced 13C and 15N solid-state nuclear magnetic resonance (NMR) techniques to 13C- and 15N-labeled melanoidins formed in dry and solution reactions. Quantitative 13C NMR shows that approximately 23% of carbon is from glycine; the approximately 2% loss compared to the 25% glycine C in the reactants is due to the COO moiety being liberated as CO2 (Strecker degradation). 13C J-modulation experiments on melanoidins made from doubly 13C-labeled glycine show that the C-C backbone bond of about two-thirds of the incorporated amino acid stays intact, and about half of all glycine is incorporated as N-CH2-COO without fragmentation.

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The structure of synthetic nanodiamond has been characterized by (13)C nuclear magnetic resonance (NMR) spectral editing combined with measurements of long-range (1)H-(13)C dipolar couplings and (13)C relaxation times. The surface layer of these approximately 4.8-nm diameter carbon particles consists mostly of sp(3)-hybridized C that is protonated or bonded to OH groups, while sp(2)-hybridized carbon makes up less than 1% of the material.

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Article Synopsis
  • The study aimed to create RNAi recombinant adenoviral vectors to specifically target and reduce the expression of GSK-3beta, a gene that plays a critical role in cell proliferation, and to analyze the influence of the Wnt/beta-catenin signaling pathway on the growth of human thyroid cells.
  • Researchers constructed an adenovirus plasmid with RNAi targeting GSK-3beta, transfected it into HEK293A cells, and then tested its ability to knock down this gene in normal human thyrocytes, assessing its impact on cell proliferation and beta-catenin levels.
  • Results showed that the GSK-3beta gene was significantly silenced in infected thyro
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Article Synopsis
  • Diabetes can make your heart and blood vessels sick, leading to problems like heart disease and strokes.
  • High levels of sugar in the blood can hurt the cells that line blood vessels, making them not work as well and even causing them to die.
  • Researchers found a way to block a protein called NF-kappaB that helps these problems, which could help develop treatments to protect blood vessel cells from damage caused by high sugar.
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Objective: To investigate the effects of topical application of emu oil on wound healing in scalded rats.

Methods: In 144 male Wistar rats with 10%; total body surface superficial II degree scald treated on a random basis with physiological saline, povidone iodine and emu oil, respectively, the changes of the wound were observed and the wound tissue and blood samples harvested at different times after injury for evaluation of histopathological changes, total tissue water content (measured by wet:dry weight ratios), and tumor necrosis factor (TNF)-alpha levels in the wound tissue and plasma by enzyme-linked immunosorbent assay (ELISA). The general condition of the wound healing was also observed.

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Two experiments were carried out to examine the effects of cultural differences between the Chinese and the US people on the perceived usability and search performance of World Wide Web (WWW) portal sites. Chinese users in Taiwan and US users in Chicago were recruited to perform searching tasks on two versions of Yahoo! portal site: the standard Yahoo! and Yahoo! Chinese. The layout of Yahoo! Chinese is the same as the layout of Yahoo!, and categories on Yahoo! Chinese have been translated from its US counterpart.

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