Identifying an effective Chinese herbal medicine for reducing postoperative hidden bleeding and stabilizing blood volume following intertrochanteric femur fracture: a Bayesian network meta-analysis of randomized controlled trials.

Objective: Chinese herbal medicine (CHM) is extensively utilized in managing hidden bleeding following an intertrochanteric femur fracture (IFF). Despite its widespread use, the most effective CHM approach for addressing hidden bleeding post-IFF remains unclear. A Bayesian network meta-analysis was conducted to identify a CHM that both effectively reduces hidden bleeding and stabilizes blood volume after IFF.

Risk Factors of Esophageal Fistula Associated with Volumetric Modulated Arc Therapy for Esophageal Squamous Cell Cancer.

Purpose: To investigate risk factors for esophageal fistula in esophageal squamous cell cancer (ESCC) patients who treated with volumetric modulated arc therapy (VMAT).

Patients And Methods: A retrospective analysis was performed on 171 ESCC patients treated with VMAT at Hefei Cancer Hospital, Chinese Academy of Sciences, from February 2017 to February 2021. Clinical and dosimetric parameters, including age, gender, feeding channel, tumor location, T stage, ulcerative tumor, were recorded.

Egln3 expression in microglia enhances the neuroinflammatory responses in Alzheimer's disease.

Alzheimer's disease (AD), characterized by cognitive and behavioral abnormalities, is the most prevalent neurodegenerative disease worldwide. Neuroinflammation, which is induced by microglial activation, resulting in the expression of a multitude of inflammatory factors, is one of the principal characteristics of AD. Herein, we found that Egln3 is differentially expressed in microglia in the brains of AD mice.

A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis.

Skin wound healing is often hindered by disrupted mitochondrial homeostasis and imbalanced macrophage glucose metabolism, posing a critical challenge to improve patient outcomes. Developing new wound healing dressings capable of effectively regulating macrophage immune-metabolic functions remains a pressing issue. Herein, a highly adhesive polyethylene glycol (PEG) hydrogel loaded with the Janus kinase 1 (JAK1) inhibitor Filgotinib (Fil@GEL) is prepared to modulate macrophage metabolic reprogramming and restore normal mitochondrial function.

Deciphering the inhibition mechanisms of microplastics on the full-stage sludge anaerobic digestion via enrichment to anaerobic microbes and toxicity of released compounds.

Increasingly accumulated microplastics (MPs) in sludge could affect the sludge treatment process, while the contributions and mechanisms of MP particles and the released organic matters (MP-DOM) are not fully understood. To fill this gap, this study systematically investigates the effects and mechanisms of MPs on sludge anaerobic digestion. In the presence of MPs, the hydrolysis and acidogenesis of organic matters and methanogenesis all decreased due to the inhibition on the activity of anaerobic microorganisms and key enzymes.

A dual-switch electrochemical aptasensor for label-free detection of thrombin and ATP based on split aptamers.

Background: Aptamers, consisting of specialized single-stranded nucleic acids, are engineered through the SELEX technique to recognize specific targets with strong affinity. Aptamers are exceptionally useful in various sensor technologies, such as fluorescence-based sensors, electrochemical sensors, and colorimetric detection systems. Due to its high sensitivity, specificity and fast response, electrochemical aptasensor shows great application prospects in analytical detection, food safety, and environmental monitoring.

Unraveling the regional environmental ecology dominated baijiu fermentation microbial community succession and associated unique flavor.

Chinese baijiu as one of the famous distilled liquor in which fermented in open environments, with various microorganisms (i.e., bacteria, fungi, and yeast) involved in their brewing process, and created corresponding unique flavor.

Regio- and Chemo-selective C-H Arylation of 3-Bromothiophene: A Synthesis Shortcut to Versatile π-Conjugated Building Blocks for Optoelectronic Materials.

Unlike traditional multi-step synthetic approaches, we developed a single-step synthesis of versatile π-conjugated building blocks bearing post-functionalizable C-H and C-Br bonds. Direct C-H arylation of 3-bromothiophene with various iodo(hetero)aryls was successfully carried out with good regio- and chemo-selectivity. Under optimized reaction conditions, 20 new compounds were facilely prepared in yields up to 91 %.

Two-Dimensional Covalent Organic Frameworks with Carbazole-Embedded Frameworks Facilitate Photocatalytic and Electrocatalytic Processes.

Catalytic technologies are pivotal in enhancing energy efficiency, promoting clean energy production, and reducing energy consumption in the chemical industry. The pursuit of novel catalysts for renewable energy is a long-term goal for researchers. In this work, we synthesized three two-dimensional covalent organic frameworks (COFs) featuring electron-rich carbazole-based architectures and evaluated their catalytic performance in photocatalytic organic reactions and electrocatalytic oxygen reduction reactions (ORRs).

High-pressure phase transitions of series of catenated nitrogen energetic crystals N (x = 4, 8, 10): A comparative DFT-D study.

Context: High-pressure chemistry has advantages in exploring novel energetic materials and is the key to the development of new high-energy materials. The complexity and danger of experimental processes require a deeper understanding by advanced simulation techniques. Therefore, a high-precision comparative DFT-D study was performed to investigate the effect of pressure on series of catenated nitrogen energetic crystals.

Direct C-H difluoroallylation of α,β-unsaturated amides and aryl amides by rhodium catalysis.

Herein, we report the first example of Rh-catalyzed C(sp)-H difluoroallylation of α,β-unsaturated amides with 3-bromo-3,3-difluoropropene under mild conditions. The features of this protocol for difluoroallylation are unprecedented vinylic substrates, ethanol as a green solvent, good functional group and air compatibility, and scale-up synthesis with low catalyst loading.

Discovery of Imidazo[1,2-]pyrazine Derivatives as Potent ENPP1 Inhibitors.

ENPP1 acts as a negative regulator of the cGAS-STING pathway through the hydrolysis of 2'3'-cGAMP. Inhibitors of ENPP1 are regarded as promising agents for stimulating the immune response in cancer immunotherapy. This study describes the identification and optimization of imidazo[1,2-]pyrazine derivative as a highly potent and selective ENPP1 inhibitor.

Application of the "3-2-1" body surface localization method in intertrochanteric femoral fractures: a technical note.

In femoral intertrochanteric fractures, poor incision positioning may result in inaccurate intramedullary nail placement direction, which increases the difficulty of reduction and thus the size and number of incisions. Repeated intraoperative fluoroscopy not only increases the radiation exposure of the surgeon but also affects the operative outcomes. This technical note proposes a method of identifying incision positioning preoperatively using the "3-2-1" body surface localization method.

Carrier effects of face mask-derived microplastics on metal ions: Enhanced adsorption by photoaging combined with biofilms, exemplified with Pb(Ⅱ).

Face masks have emerged as a significant source of microplastics (MPs) under the influence of biotic and abiotic interactions. However, the combined effects of abiotic photoaging and biofilm-loading on mask-derived MPs as carriers of metal ions are not clear. We investigated the Pb(Ⅱ) adsorption onto polypropylene (PP) and polyurethane (PU) mask-derived MPs treated by photoaging, biofilm-loading, and both combinations, evaluating the composite risks.

Salidroside Reduced Ca-CaM-CAMKII-Dependent eNOS/NO Activation to Decrease Endothelial Cell Injury Induced by Cold Combined with Hypoxia.

To investigate vascular endothelium damage in rats exposed to hypoxic and cold and the effect of salidroside in protecting against this damage. A rat isolated aortic ring hypoxia/cold model was established to simulate exposure to hypoxic and cold. The levels of endothelial cell injury markers were measured by ELISA.

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy.

Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscure. Here, we demonstrated that physiological levels of VC act to stabilize Hand1, a key bHLH transcription factor vital for the development trajectory of trophoblast giant cell (TGC) lineages, thereby promoting the differentiation of trophoblast stem cells into TGC.