Publications by authors named "XiaoWei Ma"

Wogonin, an O-methylated flavonoid extracted from Scutellaria baicalensis, has demonstrated profound neuroprotective effects in a range of central nervous system (CNS) diseases. This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. Wogonin modulates key signaling pathways, such as the MAPK, NF-κB, and ROS pathways, contributing to its anti-inflammatory, antioxidant, and antiapoptotic properties.

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To bolster the capacity for managing potential infectious diseases in the future, it is critical to develop specific antiviral drugs that can be rapidly designed and delivered precisely. Herein, a CRISPR/Cas13d system for broad-spectrum targeting of influenza A virus (IAV) from human, avian, and swine sources is designed, incorporating Cas13d mRNA and a tandem CRISPR RNA (crRNA) specific for the highly conserved regions of viral polymerase acidic (PA), nucleoprotein (NP), and matrix (M) gene segments, respectively. Given that the virus targets cells with specific receptors but is not limited to a single organ, a Susceptible Cell Selective Delivery (SCSD) system is developed by modifying a lipid nanoparticle with a peptide mimicking the function of the hemagglutinin of influenza virus to target sialic acid receptors.

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Mango ( L.) (2n = 40) is an important perennial fruit tree in tropical and subtropical regions. The lack of information on genetic diversity at the molecular level hinders efforts in mango genetic improvement and molecular marker-assisted breeding.

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Background: Although the link between fine particulate matter (PM) and influenza-like illness (ILI) is well established, the effect of the chemical constituents of PM on ILI remains unclear. This study aims to explore this effect in Guangzhou, China.

Methods: Daily data on ILI cases, PM levels, and specific PM constituents (black carbon [BC], chlorine [Cl], ammonia [NH], nitrate [NO], and sulfate [SO]) in Guangzhou, China, were collected for the period of 2014-2019.

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Background: Although Boston Naming Test has been thoroughly validated at a global level, there is limited assessment of item-level properties using modern psychometric methods.

Objective: This study aimed to investigate the construct validity and item-level properties of the color-picture version of Boston Naming Test (CP-BNT) in a Chinese cohort with neurodegenerative diseases.

Methods: This retrospective study included 424 participants, consisting of 118 normal controls, 152 with Alzheimer's disease, 101 with primary progressive aphasia, and 53 with other neurodegenerative diseases.

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Observational studies suggest a link between osteoarthritis (OA) and frailty, but the shared genetic architecture and causal relationships remain unclear. We analyzed X-ray and F-FDG PET/CT images in frail and non-frail individuals and conducted genetic correlation analyses using Linkage Disequilibrium Score Regression (LDSC) based on recent Genome-Wide Association Studies (GWAS) for OA and frailty. We identified pleiotropic single-nucleotide polymorphisms (SNPs) through Cross-Phenotype Association (CPASSOC) and Colocalization (COLOC) analyses and investigated genetic overlaps using Multi-marker Analysis of GenoMic Annotation (MAGMA).

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Article Synopsis
  • Post-translational modifications, like lactylation, are crucial in regulating protein function in bacteria, but their roles in pathogenesis are less understood than in eukaryotes.
  • The study highlights how Staphylococcus aureus modifies proteins by adding lactate to lysine residues, particularly affecting the alpha-toxin, which is key for its virulence.
  • Increased lactate levels during infections may enhance the bacterium's ability to produce toxins, boosting its virulence and making it more dangerous in infection scenarios.
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  • This study explored how exercise and vitamin D supplementation affect arterial stiffness and lipid metabolism in Type 2 diabetes patients.
  • A 12-week program involved participants engaging in moderate to vigorous exercise with some receiving vitamin D.
  • Results showed that vitamin D helped prevent decreases in ankle-brachial index and highlighted that certain lipid predictors could significantly improve predictions related to blood pressure changes and arterial stiffness.
  • Overall, vitamin D supplementation was beneficial in reducing arterial stiffness compared to conventional clinical methods.
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  • * Conducted in November-December 2020, it surveyed parents of children under 18 across eleven districts, gathering data on demographics, vaccine knowledge, willingness, and vaccination history via self-administered questionnaires.
  • * Results showed that 42.62% of participants were willing to get vaccinated, 55.40% reported their children were vaccinated, and factors influencing willingness included gender, involvement in COVID-19 work, and understanding of vaccine effectiveness.
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Background: Cardiovascular disease (CVD) remains a leading cause of mortality globally. Environmental pollutants, specifically volatile organic compounds (VOCs), have been identified as significant risk factors. This study aims to develop a machine learning (ML) model to predict CVD risk based on VOC exposure and demographic data using SHapley Additive exPlanations (SHAP) for interpretability.

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  • DNA methylation is crucial for regulating crop development, but its relationship with genetic variations and traits in natural populations is not fully understood.
  • By analyzing cotton fibers, the study found over 287 million single methylation polymorphisms (SMPs), vastly outnumbering single nucleotide polymorphisms (SNPs), highlighting the importance of methylation in gene expression.
  • The research identified numerous cis-methylation quantitative trait loci (cis-meQTLs) that are significant for fiber traits, indicating that many gene expression variations are linked to methylation rather than traditional genetic variations, opening new avenues for crop breeding improvement.
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  • Lewy body dementia (LBD) is linked to the buildup of misfolded proteins and may be influenced by lipid metabolism disorders, prompting a study that explored the connection between various serum lipids and LBD using a statistical approach called Mendelian randomization.
  • The research revealed that higher levels of low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) are associated with increased risk for LBD, particularly in individuals with the APOE4 gene.
  • Conversely, certain phosphatidylcholine types exhibited protective effects against LBD, suggesting that lipid profiles can influence the disease's development and progression.
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Activated macrophages are key effector cells and specific markers in patients with rheumatoid arthritis (RA). Cysteine cathepsin B (CTS-B) is highly expressed in macrophages and positively associated with RA activity and severity. This study aims to evaluate an activity-based multi-modality diagnostic agent, Ga-BMX2, which targets CTS-B to visualize the arthritis activity and evaluate the treatment efficacy.

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  • Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) have high mortality rates with limited treatment options, prompting research into human placental mesenchymal stem cells (hPMSCs) as a potential remedy.
  • The study involved inducing ALI in mice using lipopolysaccharide (LPS) and administering hPMSCs, showing improved lung health and reduced inflammation through changes in key inflammatory markers.
  • Findings indicated that the presence of the ACE2 gene is vital for the therapeutic effects of hPMSCs, suggesting a significant role in repairing lung tissue and providing a basis for future clinical treatments for ALI.
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Tumor-derived small extracellular vesicle (sEV) microRNAs (miRNAs) are emerging biomarkers for cancer diagnostics. Conventional sEV miRNA detection methods necessitate the lysis of sEVs, rendering them laborious and time-consuming and potentially leading to damage or loss of miRNAs. Membrane fusion-based detection of sEV miRNAs involves the preparation of probe-loaded vesicles (, liposomes or cellular vesicles), which are typically sophisticated and require specialist equipment.

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Purpose: Fibroblast activation protein (FAP) is highly expressed in the mesenchyme of most malignant epithelial tumors, while its expression is low in normal tissues. FAP inhibitors (FAPIs) bind specifically to FAP and are used for tumor-targeted diagnosis and therapy. The aim of this study was to radiosynthesize a novel molecular probe I-FAPI and evaluate its targeting and biological characteristics.

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Most environmental policy studies focus on the technical pathway effect but ignore the non-technical pathway. This paper analyzes the synergistic governance effects of three types of environmental policies on the technical and non-technical pathways. The super-efficient slacks-based measure-data envelopment analysis (SBM-DEA) assesses the green total factor productivity, while the Malmquist index decomposes into pure technical efficiency.

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Background: Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurological diseases. We previously developed a melanin-specific probe N-(2-(diethylamino)-ethyl)-F-5-fluoropicolinamide (F-P3BZA), which was initially developed for the imaging of melanoma.

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As a Brassica crop, Brassica napus typically has single flowers that contain four petals. The double-flower phenotype of rapeseed has been a desirable trait in China because of its potential commercial value in ornamental tourism. However, few double-flowered germplasms have been documented in B.

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Background: Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and is a valid indicator of insulin resistance. This study evaluated the potential predicting usefulness of the TyG index for all-cause mortality, both short- and long-term, for those concerning critical coronary artery disease (CAD).

Methods: In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered from the Medical Information Marketplace in Intensive Care (MIMIC-IV) database.

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Excessive secretion of human islet amyloid polypeptide (hIAPP) is an important pathological basis of diabetic encephalopathy (DE). In this study, we aimed to investigate the potential implications of hIAPP in DE pathogenesis. Brain magnetic resonance imaging and cognitive scales were applied to evaluate white matter damage and cognitive function.

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Funduscopic diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), significantly impact global visual health, leading to impaired vision and irreversible blindness. Delivering drugs to the posterior segment of the eye remains a challenge due to the presence of multiple physiological and anatomical barriers. Conventional drug delivery methods often prove ineffective and may cause side effects.

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