A Randomized, Comparative Trial of a Potassium-Competitive Acid Blocker (X842) and Lansoprazole for the Treatment of Patients with Erosive Esophagitis.

Introduction: X842 is a new type of gastric acid-suppressing agent with a rapid onset of action and a long duration of effect. We aim to investigate the efficacy and safety of different doses of X842 versus lansoprazole in the treatment of patients with erosive esophagitis (EE).

Methods: This phase 2 study included 90 patients with EE (Los Angeles grades A-D) who were randomized (1:1:1) to receive oral low-dose X842 (50 mg/day, n=31), high-dose X842 (100 mg/day, n=31), or lansoprazole (30 mg/day, n=30) for 4 weeks.

Synergistic activation of peroxydisulfate by photothermal and FeS-loaded air-laid cloth in a shallow continuous flow reactor.

Synergistic activation of persulfate by photothermal and solid catalysts is an effective method for degrading organic pollutants. However, the batch reaction mode not only fails to fully utilize photothermal, but also makes it hard to separate the solid catalysts from the reaction solution. In this work, a shallow continuous flow way of effluent was set up for synergistic activation of peroxydisulfate (PDS) by photothermal and FeS-loaded air-laid cloth (FeS-ALC).

Biomimetic fucoidan nanoparticles with regulation of macrophage polarization for targeted therapy of acute lung injury.

Acute lung injury (ALI) is a complex acute respiratory illness with a high mortality rate. Reactive oxygen species (ROS) play a pivotal role in ALI, inducing cellular damage, inflammation, and oxidative stress, thereby exacerbating the severity of the injury. In this study, inspired by the "subtractive" strategy, we developed a fucoidan-based macrophage membrane bio-nanosystem, abbreviated as MF@CB, designed as an anti-inflammatory and antioxidant agent to alleviate lipopolysaccharide (LPS)-induced inflammation in ALI.

Diagnostic value of selected fetal echocardiographic parameters in the prenatally suspected bicuspid aortic valve.

Objective: To explore the diagnostic value of crucial parameters of echocardiography for fetal bicuspid aortic valve (BAV) and improve diagnostic accuracy.

Methods: Fetuses with a prenatal suspected diagnosis of BAV were followed, and confirmed and misdiagnosed cases were obtained. Prenatal echocardiography was reviewed and analyzed.

Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit "ferroptosis storm" and modulate immune targeting for acute kidney injury.

Cisplatin (Cis), a potent chemotherapeutic agent, often causes acute kidney injury (AKI), limiting its clinical efficacy. RONS flares at the AKI site are a key factor in its progression. In this study, leveraging the advantages of cell membrane-coated biomimetic nanocarriers, we developed a multifunctional biomimetic nanodelivery system nano-RONS-sacrificial agent for AKI treatment.

Proteomics Analysis of Five Potential Plasma-derived Exosomal Biomarkers for Acute Myocardial Infarction.

Aims: This study was to explore the relationship between plasma exosomes and Acute myocardial infarction (AMI).

Background: Acute myocardial infarction (AMI) is one of the most common cardiovascular complications. Recent studies have shown that exosomes play a crucial role in the development and progression of cardiovascular diseases.

Spontaneous bifacial capping of perovskite film for efficient and mechanically stable flexible solar cell.

Flexible perovskite solar cells (F-PSCs) are appealing for their flexibility and high power-to-weight ratios. However, the fragile grain boundaries (GBs) in perovskite films can lead to stress and strain cracks under bending conditions, limiting the performance and stability of F-PSCs. Herein, we show that the perovskite film can facilely achieve in situ bifacial capping via introducing 4-(methoxy)benzylamine hydrobromide (MeOBABr) as the precursor additive.

Association Between Lipoprotein(a) and Dilatation of Different Aortic Segments in Hypertensive Patients.

Purpose: There are limited reports on the potential link between Lp(a) and ARDM. Thus, we examined the relationship between Lp(a) and ARDM among hypertensive patients.

Methods: We used echocardiography to measure ARDM in 513 consecutively hospitalized patients.

Automated Distal Radius and Ulna Skeletal Maturity Grading from Hand Radiographs with an Attention Multi-Task Learning Method.

Assessment of skeletal maturity is a common clinical practice to investigate adolescent growth and endocrine disorders. The distal radius and ulna (DRU) maturity classification is a practical and easy-to-use scheme that was designed for adolescent idiopathic scoliosis clinical management and presents high sensitivity in predicting the growth peak and cessation among adolescents. However, time-consuming and error-prone manual assessment limits DRU in clinical application.

Enhancing aphid resistance in horticultural crops: a breeding prospective.

Increasing agricultural losses caused by insect infestations are a significant problem, so it is important to generate pest-resistant crop varieties to address this issue. Several reviews have examined aphid-plant interactions from an entomological perspective. However, few have specifically focused on plant resistance mechanisms to aphids and their applications in breeding for aphid resistance.

Comparative efficacy and safety of Chinese patent medicines for primary insomnia: A systematic review and network meta-analysis of 109 randomized trials.

Ethnopharmacological Relevance: Chinese patent medicine (CPM) is formulated using Chinese herbal medicines as raw materials according to prescribed methods and preparation processes. It is one of the most commonly used complementary and alternative therapies for insomnia in China. Dozens of CPMs have been applied in clinical settings to treat primary insomnia, and ample evidence has proven the efficacy and safety of various CPMs.

Prevalence and influencing factors of medication-related burden among patients with late-life depression in typical city of eastern China: a cross-sectional study.

Aim: To evaluate the medication-related burden (MRB) of patients with late-life depression (LLD) and its influencing factors in China using the Living with Medicines Questionnaire-3 (LMQ-3), providing reference for reducing the MRB of those patients.

Method: A cross-sectional study was conducted between September 2023 and January 2024 on 588 patients with LLD. LMQ-3 and MRB factors questionnaire were used for data collection.

Immobilization of phosphorus (P) migrated from sediment increasing algal-available P pool in P-inactivating material.

Use of phosphorus (P)-inactivating material to immobilize P released from sediment, typically under anoxic condition, is a method often considered to reduce lake internal P loading for eutrophication control. This study found that immobilizing the released P from sediment induced accumulation of algal-available P (NaHCO and Fe oxide paper strip extractable P) in P-inactivating material which was even higher than those in raw sediment at initial stage (by 29.7% and 85.

Efficient Adsorption of Ionic Liquids in Water Using -SOH-Functionalized MIL-101(Cr): Adsorption Behavior and Mechanism.

With the increasing application of ionic liquids (ILs) in industrial areas, the removal of ILs from aqueous media has attracted considerable attention due to their potential environmental impact. In this study, we investigated the adsorption behavior and removal mechanism of ILs in water using the metal-organic framework material MIL-101(Cr) and its sulfonated derivative MIL-101(Cr)-SOH. It was observed that MIL-101(Cr)-SOH exhibited notably elevated adsorption capacity (1.

Lauric acid-mediated gelatin/hyaluronic acid composite hydrogel with effective antibacterial and immune regulation for accelerating MRSA-infected diabetic wound healing.

The infected diabetic wound healing is an increasingly severe healthcare problem worldwide. Bacterial infection and the inflammatory microenvironment hinder diabetic wound healing. Meanwhile, the combination of inhibiting bacterial growth and promoting macrophage polarization in the wound microenvironment is beneficial for treating diabetic wounds.

Clostridium Scindens Protects Against Vancomycin-Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR-FGF15/19 Signaling.

Primary sclerosing cholangitis (PSC) is characterized by abnormal bile acid metabolites and altered gut microbiota, with no effective treatments available. Vancomycin, a glycopeptide antibiotic, has emerged as a promising candidate. However, the mechanism by which vancomycin impacts the progression of PSC remains unknown.

The association between the recurrence of atrial fibrillation and the shape of left atrial lateral ridge.

To investigate the role of the geometry of the left atrial lateral ridge (LLR) in the atrial fibrillation (AF) recurrence after radiofrequency ablation (RFA). A total of 225 patients with AF who underwent RFA for the first time were retrospectively enrolled and divided into the recurrence (n = 53) and non-recurrence (n = 172) groups. The clinical data and the volume of left atrium (LAV) and the LLR geometry were analyzed.

Zeolite membrane with sub-nanofluidic channels for superior blue energy harvesting.

Blue energy, a clean energy source derived from salinity gradients, has recently drawn increased research attention. It can be harvested using charged membranes, typically composed of amorphous materials that suffer from low power density due to their disordered structure and low charge density. Crystalline materials, with inherently ordered porous structures, offer a promising alternative for overcoming these limitations.

An efficient extraction device for microplastics in marine sediments and its applications.

Microplastics, defined as small pieces of plastic with a size less than 5 millimeters, constitute a significant sink for microplastics in marine sediments. Given the potential harm to nature and human beings, accurate detection of microplastics in marine sediments is of the utmost importance. The separation of microplastics from marine sediments represents a pivotal step in the quantitative detection of microplastics.