Clinical recommendations on diagnosis and treatment of immune checkpoint inhibitor-induced renal immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are nowadays widely used in clinical oncology treatment, and significantly improve the prognosis of cancer patients. However, overactivation of T cells and related signaling pathways caused by ICIs can also induce immune-related adverse effects (irAEs). Renal immune side-effects are relatively rare, but some are serious and fatal.

Single-center study to determine the safety and efficacy of CT-707 in Chinese patients with advanced anaplastic lymphoma kinase-rearranged non-small-cell lung cancer.

Introduction: It has been proven that ALK-rearranged non-small cell lung cancer (NSCLC) is sensitive to ALK inhibitors while the chemotherapy resistance is unavoidable. In this study, safety and antitumor activity of the novel ALK inhibitor (ALKi) CT-707 were evaluated in Chinese patients with advanced ALK-rearranged NSCLC.

Methods: This single-center, open-label phase I study recruited adult patients with ALK-rearrangement (confirmed by fluorescence in situ hybridization and/or immunohistochemistry) of locally advanced/metastatic malignancies including NSCLC.

CoVO Particles with Intrinsic Multienzyme Mimetic Activities as an Effective Bioplatform for Ultrasensitive Fluorometric and Colorimetric Biosensing.

Nanozymes with various activities have attracted much attention owing to their great potential in the fields of biochemical analysis and environmental monitoring. Herein, for the first time, granular CoVO particles were synthesized using a simple hydrothermal method with pH regulation, and the triple-enzyme (oxidase-like, peroxidase-like, and catalase-like) activities and catalytic mechanisms of the prepared particles were systematically studied. On the basis of the excellent oxidase-like and peroxidase-like activities of CoVO particles, respectively, a colorimetric biosensor for detecting glutathione in health products (linear range: 2.

gen. nov., sp. nov., a novel member of the family isolated from an activated sludge sample.

A coccobacilli-shaped proteobacterium, designated strain SYSU XM001, was isolated from an activated sludge sample collected from JiMei sewage treatment plant, Xiamen, PR China. Cells were Gram-stain-negative, catalase-positive and oxidase-negative. The 16S rRNA gene sequence of strain SYSU XM001 shared less than 92 % sequence identities with members of the class , with highest sequence similarity to TH1-2 (91.

Adsorption of ferulic acid from an alkali-pretreated hydrolysate using a new effective adsorbent prepared by a thermal processing method.

A new adsorbent (AEPA) was prepared using the enzymatic hydrolyzed residue of rice straw in an air environment at 250 ℃ by a thermal processing method. Compared to the commercial adsorbent, AEPA possessed a larger specific surface area of 277.680 m g, and the maximum adsorption efficiency of ferulic acid from alkali-pretreated hydrolysate of rice straw achieved 70.

Improved volatile cargo retention and mechanical properties of capsules via sediment-free in situ polymerization with cross-linked poly(vinyl alcohol) as an emulsifier.

Hypothesis: It is hypothesized that poly(vinyl alcohol) (PVOH) as an emulsifier destabilizes the insoluble molecular aggregates by increasing interparticle interactions and their tendency toward agglomeration into large particle aggregates during the encapsulation process of one-step in situ polymerization. Porosity of capsule shells is expected to decrease with reducing agglomeration tendency to allow dense packing of smaller insoluble aggregates. Cross-linking the polymer network further reduces shell permeability to improve the retention of volatile cargos.

A 16-channel loop array for in vivo macaque whole-brain imaging at 3 T.

Non-human primates (NHPs) are vital models for neuroscience research. These animals have been widely used in behavioral, electrophysiological, molecular, and more recently, multimodal neuroimaging and neuro-engineering studies. Several RF coil arrays have been designed for functional, high-resolution brain magnetic resonance imaging (MRI), but few have been designed to accommodate multimodal devices.

Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms.

With the gradual usage of carbon dots (CDs) in the area of antiviral research, attempts have been stepped up to develop new antiviral CDs with high biocompatibility and antiviral effects. In this study, a kind of highly biocompatible CDs (Gly-CDs) is synthesized from active ingredient (glycyrrhizic acid) of Chinese herbal medicine by a hydrothermal method. Using the porcine reproductive and respiratory syndrome virus (PRRSV) as a model, it is found that the Gly-CDs inhibit PRRSV proliferation by up to 5 orders of viral titers.

Lysobacter prati sp. nov., isolated from a plateau meadow sample.

A novel proteobacterial strain designated SYSU H10001 was isolated from a soil sample collected from plateau meadow in Hongyuan county, Sichuan province, south-western China. The taxonomic position of the strain was investigated using a polyphasic approach. On the basis of 16S rRNA gene sequence similarities and phylogenetic analysis, strain SYSU H10001 was most closely related to Lysobacter soli KCTC 22011 (98.

Histologic transformation of lung cancer during pembrolizumab therapy: A case report.

Immune checkpoint inhibitors that block the programmed death 1/programmed death ligand 1 pathways are widely used to treat advanced lung cancers. There are seldom cases of histologic transformation reported after treatment with immunotherapy. Here, we report the case of a 69-year-old man with stage IV lung squamous cell carcinoma.

Abivertinib in patients with T790M-positive advanced NSCLC and its subsequent treatment with osimertinib.

Background: Abivertinib is a novel oral, third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that overcomes T790M-induced resistance in non-small cell lung cancer (NSCLC) patients. Here, we report the results of a complete and detailed clinical data of patients treated with abivertinib at our hospital in a phase I dose escalation/expansion study of abivertinib.

Methods: NSCLC patients with the EGFR T790M mutation were orally administered abivertinib (150-300 mg) twice daily for cycles of 28 continuous days and tumor response was assessed.

Comparative genomics analysis of Nitriliruptoria reveals the genomic differences and salt adaptation strategies.

The group Nitriliruptoria, recently classified as a separate class of phylum Actinobacteria, has five members at present, which belong to halophilic or halotolerant Actinobacteria. Here, we sequenced the genomes of Egicoccus halophilus EGI 80432 and Egibacter rhizosphaerae EGI 80759, and performed a comparative genomics approach to analyze the genomic differences and salt adaptation mechanisms in Nitriliruptoria. Phylogenetic analysis suggested that Euzebya tangerina F10 has a closer phylogenetic relationship to Euzebya rosea DSW09, while genomic analysis revealed highest genomic similarity with Nitriliruptor alkaliphilus ANL-iso2 and E.

Update on the classification of higher ranks in the phylum .

Genome analysis is one of the main criteria for description of new taxa. Availability of genome sequences for all the actinobacteria with a valid nomenclature will, however, require another decade's works of sequencing. This paper describes the rearrangement of the higher taxonomic ranks of the members of the phylum '', using the phylogeny of 16S rRNA gene sequences and supported by the phylogeny of the available genome sequences.

Valsartan-mediated chronotherapy in spontaneously hypertensive rats via targeting clock gene expression in vascular smooth muscle cells.

Objective: This study was to investigate the underlying mechanisms of valsartan chronotherapy in regulating blood pressure variability.

Methods: RT-PCR was used to assay clock genes expression rhythm in the hypothalamus, aortic vessels, and target organs after valsartan chronotherapy. WB was used to measure Period 1 (Per1), Period 2 (Per2) protein expression in aortic vessels, as well as to measure phosphorylation of 20-kDa regulatory myosin light chain (MLC) in VSMCs.

Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls.

Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that represents the major pathophysiological correlate of cognitive decline. However, the underlying mechanism for this excessive excitability remains incompletely understood.

A 16-channel AC/DC array coil for anesthetized monkey whole-brain imaging at 7T.

Functional magnetic resonance imaging (fMRI) in monkeys is important for bridging the gap between invasive animal brain studies and non-invasive human brain studies. To resolve the finer functional structure of the monkey brain, ultra-high-field (UHF) MR is essential, and high-performance, close-fitting RF receive coils are typically desired to fully leverage the intrinsic gains provided by UHF MRI. Moreover, static field (B0) inhomogeneity arising from the tissue susceptibility interface is more severe at UHF, presenting an obstacle to achieving high-resolution fMRI.

[Hypotension During Pembrolizumab Infusion: Case Report and Literature Review].

Immunological checkpoint inhibitors have been approved for a short period of time in China, and real-world clinical data are still in the collection stage. Reports of domestic programmed death-1 (PD-1) treatment-related adverse reactions are rare. The author reported a case of hypotension in the process of Pembrolizumab infusion and successful infusion after blood pressure recovery, hoping to provide reference for the application of immunological checkpoint inhibitors, to provide patients with the greatest clinical benefit.

Evaluation of a satellite-derived model parameterized by three soil moisture constraints to estimate terrestrial latent heat flux in the Heihe River basin of Northwest China.

Satellite-derived terrestrial latent heat flux (LE) models are useful tools to understand regional surface energy and water cycle processes for terrestrial ecosystems in the Heihe River basin (HRB) of Northwest China. This study developed a satellite-derived hybrid LE model parameterized by three soil moisture (SM) constraints: SM, relative humidity (RH), and diurnal air temperature range (DT); and assessed model performance and sensitivity. We used MODerate Resolution Imaging Spectroradiometer (MODIS) and eddy covariance (EC) data from 12 EC flux tower sites across the HRB.

Metabolite profiling of traditional Chinese medicine XIAOPI formula: An integrated strategy based on UPLC-Q-Orbitrap MS combined with network pharmacology analysis.

XIAOPI formula has been approved for mammary hyperplasia treatment by National Medical Products Administration in China. However, the absorbed substances of XIAOPI formula and their influences on metabolic pathways are largely remained unknown. Liquid chromatography coupled with mass spectrometry was used to identify the substances existing in the serum.

[Clinical Diagnosis and Treatment Recommendation of Immune-related Adverse Renal Events Related to Immune Checkpoint Inhibitor].

Immune checkpoint inhibitors (ICIs) have been used more and more Increasingly in clinical oncology treatment, which has significantly improved the prognosis of cancer patients. Over-activation of T cells and related signaling pathways may cause immune-related adverse effects. Renal immune side-effects are relatively rare, but some of them are serious and fatal.

sp. nov., a novel actinobacterium isolated from a karst cave sediment sample.

A novel actinobacterial strain, designated SYSU K10008, was isolated from a soil sample collected from a karst cave in Xingyi County, Guizhou Province, south-western PR China. The taxonomic position of the strain was investigated by using a polyphasic approach. Cells of the strain were aerobic, Gram-stain-positive and non-motile.

Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells.

Bladder cancer, which can be divided into non-muscle-invasive and muscle-invasive bladder cancer, is the most common urinary cancer in the United States. Caspase recruitment domain family member 10 (CARD10), also named CARD-containing MAGUK protein 3 (CARMA3), is a member of the CARMA family and may activate the nuclear factor kappa B (NF-κB) pathway. We utilized RNA sequencing and metabolic mass spectrometry to identify the molecular and metabolic feature of CARD10.

reveals that Li . 2006 is a later heterotypic synonym of Al-Tai and Ruan 1994.

A genome-based phylogeny of the publicly available genomes of the genus reveals that YIM 90130 is closely related to DSM 44494. Overall genome relatedness indices between the genomes of the two species were above the threshold values necessary for defining a new species (dDDH, 82.9 %; ANIb, 97.