Pharmacological Activation of GPR55 Improved Cognitive Impairment Induced by Lipopolysaccharide in Mice.

Our previous research found that activation of GPR55 can alleviate cognitive impairment induced by amyloid-beta 1-42 (Aβ) and streptozotocin in mice, but the role of GPR55 in the pathogenesis of cognitive impairment remains unknown. Here, we used a lipopolysaccharide (LPS) mouse model to further investigate the role and mechanism of O-1602, a GPR55 agonist, on cognitive dysfunction. ICR mice were treated with an intracerebroventricular (i.

Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cascading changes in cognition and behavior. G-protein-coupled receptor 55 (GPR55) has been used as a promising target for the treatment of diabetes, but its function in AD is unclear. The objective of this study was to investigate the neuroprotective effects of O-1602, a GPR55 agonist, on the streptozotocin (STZ)-induced AD mouse model.

Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ through Nrf2/HO-1 and NF-κB signaling pathway in mice.

The accumulation of amyloid beta (Aβ) in the brain is thought to be associated with cognitive deficits in Alzheimer's disease (AD). However, current methods to combat Aβ neurotoxicity are still lacking. G protein-coupled receptor 17 (GPR17) has become a target for treating inflammation in brain diseases, but it is unclear whether it has a role in AD.

Activation of GPR55 attenuates cognitive impairment and neurotoxicity in a mouse model of Alzheimer's disease induced by Aβ through inhibiting RhoA/ROCK2 pathway.

The accumulation of amyloid-β (Aβ) peptides in the brain is considered to be the initial event in the Alzheimer's disease (AD). Neurotoxicity mediated by Aβ has been demonstrated to damage the cognitive function. In the present study, we sought to determine the effects of O-1602, a specific G-protein coupled receptor 55 (GPR55) agonist, on the impairment of learning and memory induced by intracerebroventricular (i.

Facile preparation and characterization of super tough chitosan/poly(vinyl alcohol) hydrogel with low temperature resistance and anti-swelling property.

Facile preparation of super tough hydrogels with low temperature tolerance and anti-swelling property is still a challenging task for researchers. Meanwhile, the vast majority of tough hydrogels were obtained though chemical crosslinking and complicated synthesis or processing method accompanying a large number of harmful chemical reagents. Herein, the super tough chitosan/poly(vinyl alcohol) (CS/PVA) hydrogels (the maximum compressive strength of 18.

Facile synthesis of MnO nanorods grown on porous carbon for supercapacitor with enhanced electrochemical performance.

Novel MnO-doped holey carbon materials were obtained by an efficient and facile synthetic method using chitosan, potassium hydroxide and potassium permanganate as the raw materials. The carbon framework with high specific surface area was derived from chitosan by carbonization and activation approach, afterwards, MnO nanorods were grown on the surface of porous carbon by one-step agitation method and the MnO-doped holey carbon material was obtained. The scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, X-ray diffraction, N adsorption-desorption measurements, Raman spectroscopy and X-ray photoelectron spectroscopy were employed to analyze the physicochemical characteristics of the MnO-doped holey carbon materials.

Preparation and characterization of novel magnetic FeO/chitosan/Al(OH) beads and its adsorption for fluoride.

A novel magnetic bioadsorbent beads composed of FeO, chitosan, and Al(OH) (FeO/CS/Al(OH)) was synthesized by a modified solvothermal and in-situ reaction. The composite adsorbent was characterized by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, and vibrating sample magnetometer, respectively. Adsorption toward F onto FeO/CS/Al(OH) was investigated as a function of FeO concentration, initial solution pH, adsorbent dosage, initial fluorion concentration, co-existing ions in water and initial temperature.