Identification of serum metabolites associated with polybrominated diphenyl ethers (PBDEs) exposure in papillary thyroid carcinoma: a case-control study.

As the most common endocrine cancer, thyroid cancer (TC) has sharply increased globally over the past three decades. The growing incidence of TC might be counted by genetics, radiation, iodine, autoimmune disease, and exposure to environmental endocrine-disrupting chemicals (EDCs). Polybrominated diphenyl ethers (PBDEs), being typical EDCs, have been widely utilized in plastics, electronics, furniture, and textiles as flame retardants since the 1980s, and research has indicated a significant correlation between their exposure and the risk of TC.

Characterization and distribution of polybrominated diphenyl ethers in shellfish in Shenzhen coastal waters and assessment of human health risks.

This study aims to investigate the profiles of polybrominated diphenyl ethers (PBDEs) in shellfish obtained from Shenzhen coastal waters and assess the potential health risks. We analyzed 74 shellfish samples from eight different species for PBDEs (BDE-28, -47, -99, -100, -153, -154, -183, -209). The concentrations of total PBDEs in different shellfish species ranged from 2.

Body burden and influencing factors of polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs) in male workers from a municipal waste incineration plant in China.

Emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) from municipal solid waste incinerators (MSWIs) have aroused public concern around the world. However, biomonitoring evidence regarding the influence of MSWIs on the human body burden of PCDD/Fs is scarce. The aim of this study is to investigate the human body burden levels of PCDD/Fs in MSWI workers and to further explore the potential influencing factors, including duration of occupation and dietary habits, on the PCDD/F levels.

[Establishment the method for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans determination in human serum].

Objective: To establish the determination method for polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans(PCDD/Fs) in human serum, and further to provide an operable and scientific determination protocal and basis for conducting human health risk assessment for PCDD/Fs.

Methods: The serum samples were pretreated by C18 column solid phase extraction, acid silica gel column and activated carbon column purification, separated by DB-5 MS capillary column(60 m×0. 25 mm×0.

Hexabromocyclododecanes in breast milk from residents in Shenzhen, China: Implications for infant exposure.

Hexabromocyclododecanes (HBCDs) are widely used as flame retardants for various products and have become ubiquitous pollutants in environmental media. However, little is known about HBCD exposure for humans, especially in China. This study aimed to investigate the levels and profiles of hexabromocyclododecanes (HBCDs) in human breast milk and to estimate the daily HBCD intake for infants in Shenzhen, China.

Spatiotemporal variability of polybrominated diphenyl ether concentration in atmospheric fine particles in Shenzhen, China.

Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants for various products and have become ubiquitous pollutants in environmental media. However, little is known about PBDE levels in Shenzhen, a manufacturing center of electronic products. This study aimed to investigate spatiotemporal variability of PBDE concentration in atmospheric fine particles (PM) and to estimate the daily inhalation exposure doses for local residents in Shenzhen, China.

Toxaphene levels in retail food from the Pearl River Delta area of South China and an assessment of dietary intake.

Limited literature exists on toxaphene contamination in food worldwide, particularly in mainland China. In this study, three toxaphene congeners, Parlar 26 (B8-1413), Parlar 50 (B9-1679) and Parlar 62 (B9-1025), were analyzed in five different food categories from the Pearl River Delta Area in China using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), and toxaphene levels in food were reported and toxaphene dietary intake by local residents estimated. The results showed that fish contained the highest toxaphene level with a median of 12.

[Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in airborne fine particulate matter and inhalation risk assessment for local residents of Shenzhen].

Objective: To explore the levels and congener profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in airborne fine particulate matter (PM25) in Shenzhen and roughly discuss its correlations between PM25 concentration and meteorological factors.

Methods: The high volume air samplers were used to collect the samples in six sampling sites in respective winter and spring phase and summer and autumn phase. Referring to the US EPA TO-9A for dioxins detection methods, the concentrations of the 17 polychlorinated dibenzo-p-dioxins and dibenzofurans in airborne fine particulate matter were determined by HRGC/HRMS.

[Levels for toxaphene in three categories of animal originated food in Pearl River Delta area].

Objective: To explore the present contamination status and profile of toxaphene in fish, chicken and meat samples in Pearl River Delta area.

Methods: Totally 60 independent samples including fish, chicken, meat were collected from Huizhou,Guangzhou,Dongguan,Jiangmen of Pearl River Delta area in Guangdong by purposive sampling from Oct 2010 to Jun 2011. Toxaphene monomer Parlar26, Parlar50 and Parlar62 levels in three various categories of foods were quantitatively and qualitatively analyzed referencing international authoritative standard methods by utilizing isotope dilution high-resolution gas chromatography/high-resolution double-focusing magnetic mass spectrometry (HRGC-HRMS).

[Determination of hexabromocyclododecanes diastereoisomers in human breast milk by HPLC-MS/MS].

Objective: A method for the determination of ac, 3 and γ-hexabromocyclododecanes (HBCDs) in human breast milk was developed by HPLC-MS/MS.

Methods: 3 -5 g human breast milk powder was spiked with '3C-HBCDs and then been extracted using Soxhlet extraction. The extract was dried and dissolved in 6ml of cyclohexane/ethyl acetate (1:1 ), then purified by gel permeation chromatography (GPC).

[Evaluation of nutrient level and its factors of breast milk in Shenzhen City].

Objective: To investigate the nutrient level for Fat and Nutrient Elements (Ca, K, Na, Mg, Fe and Zn) in Breast Milk and its factors in Shenzhen, China. Eventually we can evaluate the nutrient study for local infants and provide a more reasonable basis for infants breast-feeding.

Methods: 235 breast milk (1 - 2 months postpartum) samples were collected in three districts of Shenzhen during the year of 2011 to 2013.