Tripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation.

Currently potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to the complexity of the pathogenic mechanisms. Here we show Tripartite motif containing 26 (TRIM26) as a critical endogenous suppressor of CCAAT/enhancer binding protein delta (C/EBPδ), and we also confirm that TRIM26 is an C/EBPδ-interacting partner protein that catalyses the ubiquitination degradation of C/EBPδ in hepatocytes. Hepatocyte-specific loss of Trim26 disrupts liver metabolic homeostasis, followed by glucose metabolic disorder, lipid accumulation, increased hepatic inflammation, and fibrosis, and dramatically facilitates NASH-related phenotype progression.

A Second-Order Method for Removing Mixed Noise from Remote Sensing Images.

Remote sensing image denoising is of great significance for the subsequent use and research of images. Gaussian noise and salt-and-pepper noise are prevalent noises in images. Contemporary denoising algorithms often exhibit limitations when addressing such mixed noise scenarios, manifesting in suboptimal denoising outcomes and the potential blurring of image edges subsequent to the denoising process.

Arsenic removal from aqueous solutions using Fe3O4-HBC composite: effect of calcination on adsorbents performance.

The presence of elevated concentration of arsenic in water sources is considered to be health hazard globally. Calcination process is known to change the surface efficacy of the adsorbent. In current study, five adsorbent composites: uncalcined and calcined Fe3O4-HBC prepared at different temperatures (400°C and 1000°C) and environment (air and nitrogen) were investigated for the adsorptive removal of As(V) and As(III) from aqueous solutions determining the influence of solution's pH, contact time, temperature, arsenic concentration and phosphate anions.

Nanoscale zero-valent iron (nZVI) assembled on magnetic Fe3O4/graphene for chromium (VI) removal from aqueous solution.

Nanoscale Zero-Valent Iron (nZVI) assembled on magnetic Fe3O4/graphene (nZVI@MG) nanocomposites was synthesized for Cr(VI) removal from aqueous solution. nZVI particles were perfectly dispersed either among Fe3O4 nanoparticles (Fe3O4 NPs) or above the basal plane of graphene. This material shows Cr(VI) removal efficiency of 83.

[Research on low-level Hg(II) removal from water by the heavy metal capturing agent].

Treatment of mercury containing wastewater using conventional approach is considered to be difficult to bring down its concentration to meet the discharge standard. In this study, we utilized dithiocarbamate (DTCR-2), 2,4,6-trimercaptotriazine(TMT-18B), Na2S and Ca(OH)2+ as the advanced treatment agents to remove low-level Hg2+ from water. Due to its better treatment effect, DTCR-2 was finally chosen as the most ideal option.

Fe(0)-Fe3O4 nanocomposites embedded polyvinyl alcohol/sodium alginate beads for chromium (VI) removal.

In this study, Fe(0)-Fe3O4 nanocomposites embedded polyvinyl alcohol (PVA)/sodium alginate (SA) beads were synthesized, which exhibited an excellent physical properties and catalytic reactivity, and a robust performance of post-separation (complete separation using a simple grille) and reusability (efficiency of 69.8% after four runs) in Cr(VI) removal. 5.

A comparison of three-dimensional marginal adaptation among three all-ceramic crown systems.

Purpose: This study was to compare the marginal adaptation of single crown made of 3 different all-ceramic systems (IPS e.max, In-Ceram alumina, Kavo Everest) in vitro using a light-body silicone supported by a heavy-body silicone material.

Methods: The crowns were made for 1 extracted maxillary premolar prepared with a 0.